20 Participants Needed

Exercise and Cognitive Rehabilitation for Cancer Survivors

(E-Co Trial)

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Kah Poh Loh, MD profile photo
Overseen ByKah Poh Loh, MD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Rochester
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Approved in 1 JurisdictionThis treatment is already approved in other countries

What You Need to Know Before You Apply

What is the purpose of this trial?

The objective of the study is to evaluate the feasibility of a combined mobile health exercise and cognitive rehabilitation intervention and its effect on cognition in a single-arm pilot study that recruits cancer survivors.

Will I have to stop taking my current medications?

The trial does not specify whether you need to stop taking your current medications. However, patients on endocrine therapies are allowed to enroll, suggesting that some medications may be continued.

Is the Exercise and Cognitive Rehabilitation intervention safe for cancer survivors?

The safety of exercise interventions for cancer survivors is not well-studied, but a protocol called the Exercise Harms Reporting Method (ExHaRM) has been developed to monitor and report any potential harms. This method helps track and assess any undesirable outcomes, although specific safety data for the Exercise and Cognitive Rehabilitation intervention is not detailed in the available research.12345

How is the E-Co treatment different from other treatments for cancer survivors?

The E-Co treatment is unique because it combines exercise and cognitive rehabilitation specifically tailored for cancer survivors, aiming to improve both physical function and cognitive abilities, unlike standard treatments that may focus on only one aspect.14678

What data supports the effectiveness of the treatment E-Co, Exercise and Cognitive Rehabilitation Intervention, for cancer survivors?

Research shows that exercise can improve cognitive function in cancer survivors, as seen in studies where physical activity enhanced cognition in breast cancer survivors. Additionally, web-based cognitive rehabilitation has been effective in improving cognitive function in cancer survivors.4791011

Who Is on the Research Team?

Kah Poh Loh, B.Med.Sci., M.B.B.Ch., B.A ...

Kah Poh Loh, MD

Principal Investigator

University of Rochester

Are You a Good Fit for This Trial?

This trial is for cancer survivors aged 60 or older who can walk, have finished their main cancer treatments, and may still be on hormone therapy. They should not have any health issues that make exercise risky, as decided by their oncologist. Participants must speak English and score ≤10 on a cognitive impact scale.

Inclusion Criteria

I have finished treatments aimed at curing my condition.
No medical contraindications for exercise per oncologist
I am currently on hormone therapy.
See 7 more

Exclusion Criteria

Physical, psychological, or social impairments that would interfere with patient's ability to participate in the study or participate in the intervention, as determined by the PIs and oncology team.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Intervention

Participants undergo a combined mobile health exercise and cognitive rehabilitation intervention

12 weeks
10 workshops (in-person or virtual)

Follow-up

Participants are monitored for cognitive outcomes and intervention feasibility

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • E-Co
Trial Overview The study is testing 'E-Co,' a mobile health program combining physical exercise with cognitive rehabilitation to see if it helps improve brain function in older adults who've survived cancer.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: E-CoExperimental Treatment1 Intervention
The E-Co intervention will integrate active components of a mobile health exercise intervention (GO-EXCAP) into a cognitive rehabilitation intervention (MAAT-G).

E-Co is already approved in United States for the following indications:

🇺🇸
Approved in United States as E-Co for:
  • Cognitive rehabilitation in older cancer survivors

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Rochester

Lead Sponsor

Trials
883
Recruited
555,000+

Published Research Related to This Trial

A Web-based cognitive rehabilitation program (eReCog) showed promise in reducing self-reported cognitive impairment in adult cancer survivors, with 76 participants involved in the study over a 4-week period.
The intervention group reported fewer memory failures in daily activities compared to the waitlist control group, suggesting potential benefits for cognitive functioning, although further research is needed to explore the underlying mechanisms.
Web-based cognitive rehabilitation for survivors of adult cancer: A randomised controlled trial.Mihuta, ME., Green, HJ., Shum, DHK.[2019]
Older breast cancer survivors (n = 395) reported significantly less physical activity compared to women without cancer (n = 374), indicating a potential area for intervention to improve their overall health.
While higher physical activity levels in survivors were associated with better cognitive function at 12 months, this relationship did not predict future physical activity or cognitive improvements, suggesting that while they are linked, one does not necessarily drive the other.
An Examination of the Longitudinal Relationship Between Cognitive Function and Physical Activity Among Older Breast Cancer Survivors in the Thinking and Living With Cancer Study.Tometich, DB., Mosher, CE., Cyders, M., et al.[2023]
An 8-week Internet-based tailored exercise program significantly improved functional capacity, as measured by the 6-minute walk test, in breast cancer survivors compared to usual care, with effects maintained at a 6-month follow-up.
The exercise program also enhanced cognitive performance, evidenced by improved recall in cognitive tests, indicating that telehealth interventions can effectively support recovery in cancer survivors.
Effect of an Internet-based telehealth system on functional capacity and cognition in breast cancer survivors: a secondary analysis of a randomized controlled trial.Galiano-Castillo, N., Arroyo-Morales, M., Lozano-Lozano, M., et al.[2019]

Citations

Web-based cognitive rehabilitation for survivors of adult cancer: A randomised controlled trial. [2019]
An Examination of the Longitudinal Relationship Between Cognitive Function and Physical Activity Among Older Breast Cancer Survivors in the Thinking and Living With Cancer Study. [2023]
Effect of an Internet-based telehealth system on functional capacity and cognition in breast cancer survivors: a secondary analysis of a randomized controlled trial. [2019]
A randomized trial of physical activity for cognitive functioning in breast cancer survivors: Rationale and study design of I Can! Improving Cognition After Cancer. [2023]
Effects of yoga, aerobic, and stretching and toning exercises on cognition in adult cancer survivors: protocol of the STAY Fit pilot randomized controlled trial. [2021]
Recruitment rates and strategies in exercise trials in cancer survivorship: a systematic review. [2023]
Pilot Randomized Controlled Trial of Feasibility, Acceptability, and Preliminary Efficacy of a Web-Based Physical Activity and Sedentary Time Intervention for Survivors of Physical Inactivity-Related Cancers. [2023]
Impact of increasing physical activity on cognitive functioning in breast cancer survivors: Rationale and study design of Memory & Motion. [2022]
Practical suggestions for harms reporting in exercise oncology: the Exercise Harms Reporting Method (ExHaRM). [2023]
10.United Statespubmed.ncbi.nlm.nih.gov
Prevalence and correlates of strength exercise among breast, prostate, and colorectal cancer survivors. [2022]
The feasibility of implementing an exercise programme for deconditioned cancer survivors in a national cancer centre: FIXCAS Study. [2021]
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