Epinephrine Dosing for Cardiac Arrest
(EpiDOSE Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
What data supports the effectiveness of the drug epinephrine for cardiac arrest?
Research suggests that higher doses of epinephrine may improve blood flow to the heart and brain during cardiac arrest, potentially leading to better survival rates. However, the traditional dose has little scientific basis, and more studies are needed to confirm the benefits of higher doses in humans.12345
Is epinephrine generally safe for use in humans?
How is the drug epinephrine unique in treating cardiac arrest?
Epinephrine is unique in treating cardiac arrest because it is administered intravenously every 3-5 minutes to improve blood flow to the heart and brain, and there is ongoing research to determine the optimal dosing period and amount, which may vary based on the duration of the cardiac arrest.124910
What is the purpose of this trial?
The objective of this randomized controlled trial is to evaluate the effectiveness of a low cumulative dose of epinephrine compared to a standard cumulative dose of epinephrine during resuscitation from ventricular fibrillation (VF) or ventricular tachycardia (VT) in adult out-of-hospital cardiac arrest (OHCA) patients.
Research Team
Steve Lin, MD, MSc
Principal Investigator
St. Michael's Hospital
Paul Dorian, MD, MSc
Principal Investigator
St. Michael's Hospital
Eligibility Criteria
This trial is for adults who've had a cardiac arrest outside of the hospital with specific heart rhythms (VF or pulseless VT) and were treated by paramedics. They must have IV access established. It's not for those under 18, non-cardiac caused arrests, prisoners, people allergic to epinephrine, or if they've already received epinephrine.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Eligible OHCA patients receive either a low or standard cumulative dose of epinephrine during resuscitation
Follow-up
Participants are monitored for survival to hospital discharge and other outcomes using administrative databases and telephone interviews
Treatment Details
Interventions
- Epinephrine
Epinephrine is already approved in European Union, United States, Canada for the following indications:
- Anaphylaxis
- Cardiac arrest
- Severe allergic reactions
- Anaphylaxis
- Cardiac arrest
- Severe allergic reactions
- Anaphylaxis
- Cardiac arrest
- Severe allergic reactions
Find a Clinic Near You
Who Is Running the Clinical Trial?
Unity Health Toronto
Lead Sponsor
Canadian Institutes of Health Research (CIHR)
Collaborator
Pfizer
Industry Sponsor
Albert Bourla
Pfizer
Chief Executive Officer since 2019
PhD in Biotechnology of Reproduction, Aristotle University of Thessaloniki
Patrizia Cavazzoni
Pfizer
Chief Medical Officer
MD from McGill University