Chemo + EUS-RFA for Pancreatic Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This is a single arm study in the treatment of pancreatic ductal adenocarcinoma (PDAC). The investigators propose to test the tolerability of chemotherapy plus endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) using the RF Electrode in patients receiving palliative second or third line therapy for unresectable non-metastatic pancreatic cancer.
Do I need to stop my current medications for this trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is the combination of chemotherapy and EUS-RFA generally safe for humans?
How is the treatment Chemo + EUS-RFA unique for pancreatic cancer?
Chemo + EUS-RFA is unique because it combines chemotherapy with a minimally invasive technique called endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA), which targets and destroys cancer cells directly in the pancreas, potentially reducing side effects compared to traditional surgery.678910
What data supports the effectiveness of the treatment Chemo + EUS-RFA for Pancreatic Cancer?
Research shows that chemotherapy can slightly improve survival and quality of life in some pancreatic cancer patients, although its overall effectiveness is limited. Combining chemotherapy with surgery has been suggested to improve survival rates, and newer treatments like gemcitabine have shown better results with fewer side effects compared to older drugs.1112131415
Who Is on the Research Team?
Tamas A. Gonda, MD
Principal Investigator
NYU Langone Health
Are You a Good Fit for This Trial?
This trial is for individuals with pancreatic cancer that hasn't spread far (locally advanced) and is between 1-4cm in size. They should have tried chemotherapy already without success, be reasonably well (ECOG 0-2), and not be candidates for surgery. Pregnant people or those who can't consent, have tumors smaller than 1cm or larger than 4cm, or masses that can't be reached endoscopically are excluded.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive chemotherapy and undergo EUS-RFA procedures
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Chemotherapy
- Endoscopic Ultrasound-Guided Radiofrequency Ablation (EUS-RFA)
Chemotherapy is already approved in European Union, United States, Canada, Japan, China, Switzerland for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
NYU Langone Health
Lead Sponsor
Taewoong Medical
Collaborator