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Cannabinoid

Cannabidiol for Social Anxiety Disorder (CAN-SAD Trial)

Phase 4
Waitlist Available
Led By John Gabrieli, PhD
Research Sponsored by Massachusetts Institute of Technology
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up -180 minutes, -15 minutes, -5 minutes, +10 minutes, +20 minutes, +30 minutes
Awards & highlights

CAN-SAD Trial Summary

This trial tests if taking one dose of a cannabidiol medicine can reduce symptoms of social anxiety disorder.

Who is the study for?
Adults aged 18-55 with social anxiety disorder, not using drugs or certain medications like beta-blockers and benzodiazepines recently. Participants must be fluent in English, right-hand dominant, have stable medication use for the last month, and women must test negative for pregnancy.Check my eligibility
What is being tested?
The trial is testing if a single dose of Epidiolex (cannabidiol) can lower anxiety levels in people with social anxiety disorder. It measures psychological responses, physiological signs of stress, and brain activity changes.See study design
What are the potential side effects?
Cannabidiol may cause tiredness, diarrhea, changes in appetite/weight. Rarely it could lead to liver issues or affect mood and behavior. Side effects vary from person to person.

CAN-SAD Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~-180 minutes, -15 minutes, -5 minutes, +10 minutes, +20 minutes, +30 minutes
This trial's timeline: 3 weeks for screening, Varies for treatment, and -180 minutes, -15 minutes, -5 minutes, +10 minutes, +20 minutes, +30 minutes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Acute Subjective Anxiety
Secondary outcome measures
Differences in Salivary Alpha Amylase
Other outcome measures
Differences in fMRI BOLD Response

CAN-SAD Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: CannabidiolActive Control1 Intervention
300mg Cannabidiol (3mL Epidiolex), oral, single-dose
Group II: PlaceboPlacebo Group1 Intervention
Placebo (3mL sesame seed oil), oral, single-dose

Find a Location

Who is running the clinical trial?

Massachusetts Institute of TechnologyLead Sponsor
97 Previous Clinical Trials
12,729,937 Total Patients Enrolled
Massachusetts General HospitalOTHER
2,928 Previous Clinical Trials
13,198,305 Total Patients Enrolled
John Gabrieli, PhDPrincipal InvestigatorMassachusetts Institute of Technology
4 Previous Clinical Trials
382 Total Patients Enrolled

Media Library

Cannabidiol (Cannabinoid) Clinical Trial Eligibility Overview. Trial Name: NCT05649059 — Phase 4
Social Anxiety Disorder Research Study Groups: Placebo, Cannabidiol
Social Anxiety Disorder Clinical Trial 2023: Cannabidiol Highlights & Side Effects. Trial Name: NCT05649059 — Phase 4
Cannabidiol (Cannabinoid) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05649059 — Phase 4

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does the trial enrollment criteria include adults aged 20 and above?

"This trial only allows patients aged 18 to 55 to enroll. Conversely, 111 studies are targeted towards minors and 276 for those over the age of 65."

Answered by AI

Could you inform me of potential hazards related to Cannabidiol use?

"There exists ample evidence of Cannabidiol's safety, which is why it achieved a score of 3 at Power. This treatment has already been approved by the FDA, making this Phase 4 trial possible."

Answered by AI

Are there still opportunities for enrolment in this research experiment?

"The data posted on clinicaltrials.gov indicates that this medical trial is no longer seeking participants, as it was initially published in January 1st 2023 and last updated December 12th 2022. Nonetheless, 420 other studies are actively recruiting right now."

Answered by AI

Is there eligibility criteria for me to join this experiment?

"This research project is seeking to enrol 50 volunteers suffering from social phobia, aged between 18 and 55. Candidates must be able to provide written consent, converse fluently in English, right-handed, stable on their current medications for the last 30 days, pass a pregnancy test (if female), urine drug screening and have an existing diagnosis of Social anxiety Disorder (QuickSCID-5) with Liebowitz Social Anxiety Scale score ≥ 60)."

Answered by AI
~29 spots leftby Dec 2024