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Bazedoxifene + Estrogens for Atherosclerosis (APPT Trial)
APPT Trial Summary
This trial is designed to test the effects of a tissue selective estrogen complex on the progression of subclinical atherosclerosis and cognitive decline in 360 postmenopausal women.
APPT Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.APPT Trial Design
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Who is running the clinical trial?
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- I have a history of heart problems.Your blood test shows that you have high levels of creatinine, which is a waste product in the blood.I have been using hormone replacement therapy for the past month.My doctor expects I have less than 5 years to live due to my illness.I have had breast cancer in the past.My blood pressure is not higher than 180/110 mmHg.Your blood has high levels of triglycerides, above 500 mg/dL.I am a woman aged 45-59, less than 6 years postmenopausal, with low estrogen levels.I have had a deep vein thrombosis or pulmonary embolism.I have cirrhosis or another liver disease.I have diabetes or my blood sugar level is high.I have had a hysterectomy.
- Group 1: Placebo
- Group 2: BZA/CE
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Are recruitment efforts still underway for this experiment?
"According to the official clinicaltrials.gov page, applications for this trial are still being accepted. This study was initially announced on April 13th 2021 and has since been updated as of June 30th 2022."
What criteria are necessary for enrolment in this clinical experiment?
"This investigation is recruiting up to 400 individuals with atherogenesis who are between 45 and 59 years old."
What adverse effects have been observed when taking Oral bazedoxifene 20 mg / conjugated estrogens 0.45 mg?
"With Phase 2 clinical data confirming its safety, our team at Power assigned Oral bazedoxifene 20 mg / conjugated estrogens 0.45 mg a score of 2 on the 1-3 scale. No efficacy studies have been conducted yet."
Could you please elucidate the past experiments involving Oral bazedoxifene 20 mg / conjugated estrogens 0.45 mg?
"Currently, Oral bazedoxifene 20 mg / conjugated estrogens 0.45 mg is being investigated in 15 clinical trials with one of them in the final stage of evaluation. Most studies are found in League City, Texas while 31 sites across the country have opened up recruitment for this medication."
Is eligibility for this experiment limited to individuals aged 25 or above?
"To be considered for this clinical trial, prospective participants must fall within the age range of 45-59. There are 26 studies recruiting patients under 18 years old and 662 aiming to enroll persons that have exceeded 65 years of life."
What medical conditions have been effectively managed with Oral bazedoxifene 20 mg / conjugated estrogens 0.45 mg?
"Oral bazedoxifene 20 mg / conjugated estrogens 0.45 mg is a viable treatment for premature menopause, female castration, and vasomotor system issues."
What is the aggregate size of participants in this clinical research?
"Affirmative. According to the clinicaltrials.gov website, recruitment is still open for this trial which was first posted on April 13th 2021 and updated most recently on June 30th 2022. The researchers are looking to sign up 400 individuals at a single site."
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