Inhalational vs Intravenous Anesthesia for Colorectal Cancer Surgery
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial evaluates how inhalational anesthesia (drawn in through the lungs) and total intravenous anesthesia (TIVA) (through a needle in a vein in the arm) change the body's ability to recover from surgery or whether they impact the immune system immediately after surgery in patients with colon cancer. It is unknown whether these types of anesthesia change recovery from surgery or change the chances cancer comes back following surgery. This study may help researchers learn how different types of anesthesia affect recovery from colon cancer surgery.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is inhalational or intravenous anesthesia safe for colorectal cancer surgery?
Both inhalational and intravenous anesthesia have been used safely in cancer surgeries, but some studies suggest that intravenous anesthesia might be associated with fewer complications and lower mortality rates compared to inhalational anesthesia. However, the evidence is of low quality, and more research is needed to confirm these findings.12345
How does the treatment for colorectal cancer surgery differ from other treatments?
The treatment for colorectal cancer surgery using inhalational anesthesia, like sevoflurane, is unique because it offers a short induction time, stable maintenance, and quick recovery compared to intravenous anesthesia, such as propofol. Additionally, inhalational anesthesia may have immune-modulating effects that could influence cancer recurrence, which is a consideration not typically associated with intravenous anesthesia.14678
What data supports the effectiveness of the treatment for colorectal cancer surgery?
Who Is on the Research Team?
Luke V Selby
Principal Investigator
University of Kansas
Are You a Good Fit for This Trial?
This trial is for adults (18+) with colon cancer who are medically fit for surgery and can complete study questionnaires. They must be willing to follow the study procedures throughout its duration, have an ECOG status of 0-2, and provide written consent. Excluded are those with allergies to eggs or soy, a history of malignant hyperthermia, rectal adenocarcinoma diagnosis, enrollment in another therapeutic trial, severe psychiatric or social issues affecting compliance, active serious infections within two weeks prior to treatment start date, prisoner status, inflammatory bowel disease diagnosis or planned complex surgeries.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Patients receive either inhalational anesthesia with sevoflurane and fentanyl or intravenous anesthesia with fentanyl and propofol during surgery. Blood and tissue samples are collected.
Immediate Post-operative Recovery
Patient recovery is monitored, including pain management, nausea, and return of GI function. Blood samples are collected for ctDNA and inflammatory markers.
Follow-up
Participants are monitored for safety and effectiveness after treatment, including assessments of post-operative recovery, immune suppression, and survival.
Long-term Follow-up
Participants are followed up yearly for 5 years to assess long-term outcomes such as disease-free survival and overall survival.
What Are the Treatments Tested in This Trial?
Interventions
- Biospecimen Collection
- Electronic Health Record Review
- Surgical Procedure
Surgical Procedure is already approved in United States, European Union for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Kansas Medical Center
Lead Sponsor
National Cancer Institute (NCI)
Collaborator