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Minimally Invasive vs. Conventional Heart Bypass for Coronary Artery Disease (MIST Trial)
N/A
Recruiting
Led By Marc Ruel, MD
Research Sponsored by Ottawa Heart Institute Research Corporation
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Angiographically-confirmed multi-vessel coronary artery disease lesions with >=70% in at least 2 major epicardial vessels in 2 or more coronary artery territories (left anterior descending (LAD), circumflex (CX) and right coronary artery (RCA)) OR lesions >=50% in the left main (LM)
18 years of age or older
Timeline
Screening 3 weeks
Treatment Varies
Follow Up during the first 2 months after surgery
Awards & highlights
MIST Trial Summary
This trial is testing whether minimally invasive coronary surgery (MICS) is better than conventional surgery for quality of life and recovery.
Who is the study for?
Adults with multi-vessel coronary artery disease suitable for bypass surgery via sternotomy or a minimally-invasive approach, who can follow the study's procedures. Excluded are those under 18, previous heart surgery patients, emergency cases, and individuals with life-threatening diseases or conditions that contraindicate the surgical methods.Check my eligibility
What is being tested?
The MIST Trial compares two types of heart bypass surgeries: MICS CABG (through a small chest incision) and conventional sternotomy CABG (through a larger chest opening). It aims to assess which method offers better quality of life and quicker recovery post-surgery using patient questionnaires over one year.See study design
What are the potential side effects?
Potential side effects may include risks associated with any major heart surgery such as infection at the incision site, bleeding, blood clots, pneumonia, or reactions to anesthesia. The less invasive MICS procedure might reduce some risks compared to conventional CABG.
MIST Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I have severe blockages in two or more of my heart's major arteries.
Select...
I am 18 years old or older.
MIST Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ during the first 2 months after surgery
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~during the first 2 months after surgery
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Quality of life - physical function
Secondary outcome measures
Angina
Atrial fibrillation
Duration of intubation
+11 moreMIST Trial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: Minimally-invasive CABGExperimental Treatment1 Intervention
Patients in this group will undergo coronary artery bypass grafting (CABG) using a minimally-invasive approach (MICS CABG), through smaller incisions between the ribs.
Group II: CABG with sternotomyActive Control1 Intervention
Patients in this group will undergo coronary artery bypass grafting (CABG) in the usual way, through an incision in the middle of the chest, through the breastbone or sternum (conventional CABG).
Find a Location
Who is running the clinical trial?
Fresno Heart and Surgical HospitalUNKNOWN
Far Eastern Memorial HospitalOTHER
260 Previous Clinical Trials
1,253,620 Total Patients Enrolled
8 Trials studying Coronary Artery Disease
979 Patients Enrolled for Coronary Artery Disease
Ichinomiya-Nishi HospitalUNKNOWN
1 Previous Clinical Trials
2,500 Total Patients Enrolled
1 Trials studying Coronary Artery Disease
2,500 Patients Enrolled for Coronary Artery Disease
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I cannot have traditional open-heart surgery.My doctor thinks I can have heart surgery through a cut in my chest or a less invasive method.I can attend all required follow-up visits for the study.I have had heart surgery, chest radiation, or major chest injury.I have severe blockages in two or more of my heart's major arteries.I am 18 years old or older.I am having a heart surgery along with a bypass.I do not have severe chest deformity, serious lung or heart issues, extreme obesity, or missing femoral pulses.I had emergency heart bypass surgery due to unstable heart function.My doctor thinks I can have heart surgery through a cut in my chest or a less invasive method.I am under 18 years old.I have a serious illness that may shorten my life to under 2 years.I can attend all required follow-up visits for the study.
Research Study Groups:
This trial has the following groups:- Group 1: CABG with sternotomy
- Group 2: Minimally-invasive CABG
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are there any open slots left in this clinical experiment?
"Affirmative. The information on clinicaltrials.gov demonstrates that this trial, first posted September 1st 2018, is looking for participants at the present moment in time. 176 applicants are required from 8 distinct sites."
Answered by AI
To what extent has this trial been implemented across the United States?
"Participants can join this experiment at University Health Network in Toronto, Canada; Carolinas Medical Centre in Charlotte, North carolina; Division of Cardiac Surgery, University of Ottawa Heart Institute in Ottawa, California and 8 other sites."
Answered by AI
What is the present scope of individuals involved in this clinical trial?
"That is correct. According to the details on clinicaltrials.gov, this ongoing research requires 176 patients from 8 different clinical sites and was posted in September of 2018 with its most recent edit taking place in November 2022."
Answered by AI
Who else is applying?
How old are they?
18 - 65
What site did they apply to?
Fresno Heart Hospital
What portion of applicants met pre-screening criteria?
Met criteria
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