Dr. Mary Zhang, MD, PhD

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University of Ottawa Heart Institute

Studies Coronary Artery Disease
Studies Mitral Regurgitation
2 reported clinical trials
4 drugs studied

Affiliated Hospitals

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University Of Ottawa Heart Institute
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Division Of Cardiac Surgery, University Of Ottawa Heart Institute

Clinical Trials Mary Zhang, MD, PhD is currently running

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Percutaneous vs Surgical Mitral Valve Repair

for Mitral Valve Regurgitation

Ischemic mitral regurgitation (MR) and coronary artery disease is common and associated with significant morbidity and mortality. Ischemic MR has been traditionally treated surgically through either valve repair or replacement at the time of concomitant bypass grafting. Although patients with ischemic MR represent a heterogeneous group, outcomes for these patients over the intermediate term is poor owing to left ventricle (LV) dysfunction causing MR and the presence of coronary disease, which portends poor survival. There is an emergence of percutaneous therapies to treat MR which have been shown to be a less invasive, safe, and viable approach to treat comorbid patients. The decision to treat ischemic MR either surgically or percutaneously is influenced by the presence of coronary disease and the ability to provide adequate revascularization. Mitral valve surgery concomitant to surgical revascularization, however, is associated with a several fold increase in mortality. In fact, the incremental risk increase is further magnified in high-risk patients. We therefore propose a novel prospective study to guide intervention for ischemic MR. Patients will be randomized to undergo surgical therapy with either mitral repair/replacement and/or concomitant coronary artery bypass grafting OR percutaneous mitral repair, followed by coronary artery bypass grafting.
Recruiting1 award N/A2 criteria
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Minimally Invasive vs. Conventional Heart Bypass

for Coronary Artery Disease

This trial compares a less invasive heart surgery to traditional open-chest surgery in patients with multiple blocked heart arteries. The goal is to see if the less invasive method helps patients recover quicker and improve their quality of life. The less invasive surgery was developed to allow adequate exposure and complete treatment from a small incision without the need for a heart-lung machine.
Recruiting1 award N/A4 criteria

More about Mary Zhang, MD, PhD

Clinical Trial Related4 years of experience running clinical trials · Led 2 trials as a Principal Investigator · 2 Active Clinical Trials
Treatments Mary Zhang, MD, PhD has experience with
  • Percutaneous Mitral Valve Repair
  • Surgical Mitral Valve Repair/replacement
  • Conventional CABG
  • MICS CABG

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