← Back to Search

Other

Observational Group for Glaucoma

N/A

Recruiting

Led By Kanwal Nischal, MD,FRCOphth

Research Sponsored by University of Pittsburgh

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Any child undergoing an eye exam under anesthesia for an ophthalmologic reason

Children between the ages newborn to 8 years of age

Timeline

Screening 3 weeks

Treatment Varies

Follow Up after induction of anesthesia end tidal co2 will be manipulated to 40mmhg, then 30mmhg and then 50mmhg. the end tidal co2 levels will be held for at least 5 minutes after each ventilation manipulation;at the end of 5 minute period choroid images taken

Awards & highlights

Study Summary

This trial aims to study how the amount of carbon dioxide in the blood and the pressure inside the eye affect the volume of a specific part of the eye using a special imaging technique during eye exams done while

Who is the study for?

This clinical trial is for children from newborns up to 8 years old who are already scheduled for an eye exam under anesthesia due to ophthalmologic reasons. It's not suitable for kids over 8, those with conditions affecting brain blood flow regulation, increased pressure inside the skull, or any issues the anesthesiologist thinks could cause problems.Check my eligibility

What is being tested?

The study is examining how changing the amount of carbon dioxide (CO2) in a child's breath affects the thickness of part of their eye called the choroid. This will be done using special imaging during an eye exam while they're under anesthesia.See study design

What are the potential side effects?

Since this trial involves ventilation manipulation rather than medication, side effects may include discomfort from changes in breathing patterns and potential risks associated with general anesthesia.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

My child needs an eye exam under anesthesia for an eye condition.

Select...

My child is between newborn and 8 years old.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ after induction of anesthesia end tidal co2 will be manipulated to 40mmhg, then 30mmhg and then 50mmhg. the end tidal co2 levels will be held for at least 5 minutes after each ventilation manipulation and at the end of this 5 minute period iop measured

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~after induction of anesthesia end tidal co2 will be manipulated to 40mmhg, then 30mmhg and then 50mmhg. the end tidal co2 levels will be held for at least 5 minutes after each ventilation manipulation and at the end of this 5 minute period iop measured

This trial's timeline: 3 weeks for screening, Varies for treatment, and after induction of anesthesia end tidal co2 will be manipulated to 40mmhg, then 30mmhg and then 50mmhg. the end tidal co2 levels will be held for at least 5 minutes after each ventilation manipulation and at the end of this 5 minute period iop measured for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Intraocular Pressure (IOP) (mmHg)

Secondary outcome measures

Choroidal thickness ( microns)

Trial Design

1Treatment groups

Experimental Treatment

Group I: Observational GroupExperimental Treatment1 Intervention

Manipulation of end tidal carbon dioxide in subjects

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of PittsburghLead Sponsor

1,723 Previous Clinical Trials

16,342,936 Total Patients Enrolled

7 Trials studying Glaucoma

11,145 Patients Enrolled for Glaucoma

Amy Monroe, MPH, MBAStudy DirectorUniversity of Pittsburgh

3 Previous Clinical Trials

1,615 Total Patients Enrolled

Kanwal Nischal, MD,FRCOphthPrincipal InvestigatorUniversity of Pittsburgh

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any vacancies available for patients to participate in this trial?

"As indicated by clinicaltrials.gov, this investigation is actively seeking participants. The trial was initially made public on February 27th, 2023 and the latest update occurred on February 16th, 2024."

Answered by AI

What is the current enrollment size of participants for this research?

"Affirmative, details from clinicaltrials.gov indicate that recruitment is ongoing for this investigation. The trial was first listed on February 27th, 2023 and last revised on February 16th, 2024. Enrollment aims to reach a total of 20 participants at one site."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Effect of Raised End-Tidal pCo2 on Choroidal Volume

Kanwal Nischal 2023. "Effect of Raised End-Tidal pCo2 on Choroidal Volume". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06275308.

All > Paid Studies Pittsburgh