Your session is about to expire
← Back to Search
Other
Propofol vs Inhaled Anesthesia for Surgery (THRIVE Trial)
N/A
Recruiting
Led By Michael S Avidan, MBBcH
Research Sponsored by Washington University School of Medicine
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Undergoing elective non-cardiac surgery expected to last ≥ 60 min requiring general anesthesia with a tracheal tube or laryngeal mask airway (or similar supra-glottic device)
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 30 - 34 days after surgery
Awards & highlights
THRIVE Trial Summary
This trial will compare two anesthesia techniques to see which yields better patient recovery outcomes and any potential risks.
Who is the study for?
This trial is for adults aged 18+ who are having elective non-cardiac surgery lasting at least an hour with general anesthesia. It's not for those unable to consent in English/Spanish, pregnant women, recent or soon-to-have other surgeries under anesthesia, or if they have allergies to the study drugs or conditions like malignant hyperthermia.Check my eligibility
What is being tested?
The trial compares two types of general anesthesia: Propofol TIVA (total intravenous anesthesia) and INVA (inhaled volatile agents), across three surgical categories. The goal is to see which method offers better recovery experiences and ensure that TIVA doesn't significantly increase the risk of being aware during surgery.See study design
What are the potential side effects?
Possible side effects include typical reactions to anesthesia such as nausea, vomiting, sore throat from the breathing tube or mask, drowsiness after surgery, muscle aches, confusion upon waking up from the anesthesia and less commonly intraoperative awareness.
THRIVE Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am scheduled for a non-heart surgery under general anesthesia lasting at least 60 minutes.
THRIVE Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 1 - 7 days prior to surgery
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 - 7 days prior to surgery
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Incidence of unintended intraoperative awareness with recall on POD1 or POD30
Quality of Recovery-15 (QOR 15) score on POD1 after Major inpatient surgery
Quality of Recovery-15 score on POD1 after Outpatient surgery
+1 moreSecondary outcome measures
Bauer Questionnaire - Patient satisfaction with anesthesia at POD2
Days alive and at-home at POD30 after major inpatient surgery
Days alive and at-home at POD30 after minor inpatient surgery
+41 moreOther outcome measures
Daily standing hours as measured by wearable device at baseline for those scheduled for major inpatient surgery.
Daily standing hours as measured by wearable device at baseline for those scheduled for minor inpatient surgery.
Daily standing hours as measured by wearable device at baseline for those scheduled for outpatient surgery.
+36 moreTHRIVE Trial Design
2Treatment groups
Active Control
Group I: Propofol total intravenous anesthesia (TIVA)Active Control1 Intervention
No administration of inhaled agent.
Group II: inhaled volatile general anesthesia (INVA)Active Control1 Intervention
Must administer inhaled agent.
Find a Location
Who is running the clinical trial?
Patient-Centered Outcomes Research InstituteOTHER
551 Previous Clinical Trials
29,984,958 Total Patients Enrolled
Washington University School of MedicineLead Sponsor
1,937 Previous Clinical Trials
2,287,195 Total Patients Enrolled
2 Trials studying Postoperative Pain
333 Patients Enrolled for Postoperative Pain
University of MichiganOTHER
1,798 Previous Clinical Trials
6,365,638 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I will be on a breathing machine after surgery.I have had or will have surgery with anesthesia within 30 days around my surgery date.You have experienced being aware during surgery while under general anesthesia, and you have told someone about it.I need a special type of anesthesia for my surgery due to specific monitoring.I cannot use propofol due to an allergy, severe nausea, or a history of malignant hyperthermia.My surgery requires a specific type of anesthesia as per the approved protocol.I am 18 years old or older.I am scheduled for a non-heart surgery under general anesthesia lasting at least 60 minutes.I can provide informed consent in English or Spanish.You are pregnant, as confirmed by a test or by telling the doctor.
Research Study Groups:
This trial has the following groups:- Group 1: Propofol total intravenous anesthesia (TIVA)
- Group 2: inhaled volatile general anesthesia (INVA)
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are recruitment efforts still underway for this trial?
"As per the information available on clinicaltrials.gov, this study — which first appeared online on August 1st 2023 and was last updated 7 days later — is no longer seeking new participants; however, there are 2390 other medical trials that require subjects at present."
Answered by AI
What is the primary aim of this investigation?
"This evaluation, which records data between baseline and day one, is meant to measure the Quality of Recovery-15 score for patients undergoing minor inpatient surgery on POD1. Additionally, a comparison will be made between their QOR scores from before and after outpatient surgery (POD0), as well as major inpatient operations taken at POD2. The higher the given score out of 150 points, the more likely it is that they have returned back to their pre-surgery level of quality."
Answered by AI
Other Trials to Consider
Popular Categories
Share this study with friends
Copy Link
Messenger