200 Participants Needed

Ultrasound for Throat Issues

AL
SA
Overseen BySara Albert, BA
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Weill Medical College of Cornell University
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Approved in 3 JurisdictionsThis treatment is already approved in other countries

What You Need to Know Before You Apply

What is the purpose of this trial?

Investigators will assess the usefulness of using ultrasound in office procedures for laryngology interventions. Participants who qualify will be adults who are undergoing superior laryngeal nerve block, injection laryngoplasty, swallowing evaluation, voice evaluation and voice therapy.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Is ultrasound generally safe for humans?

Ultrasound, including its use with contrast agents, is generally considered safe for humans. Serious adverse reactions are rare, and any minor side effects like headache or nausea usually resolve on their own. It's important to use the lowest necessary settings to ensure safety.12345

How does ultrasound treatment for throat issues differ from other treatments?

Ultrasound treatment for throat issues is unique because it is a non-invasive imaging technique that provides high-resolution images of the throat's structures, which can help in diagnosing and managing conditions without the need for more invasive procedures like endoscopy. This makes it particularly useful during situations like the SARS-CoV-2 pandemic, where reducing exposure to aerosol-generating procedures is important.678910

What data supports the effectiveness of the treatment Ultrasound for Throat Issues?

Ultrasound can improve patient satisfaction by speeding up diagnosis and reducing hospital stay time. It has also been used successfully to diagnose throat tumors and assess tonsil issues in children, showing its usefulness in throat-related conditions.1112131415

Who Is on the Research Team?

AR

Anaïs Rameau, MD

Principal Investigator

Weill Medical College of Cornell University

Are You a Good Fit for This Trial?

Adults with voice and swallowing issues like vocal cord paralysis, weakness, atrophy, hoarseness, coughing, or difficulty swallowing may join. Specific details on who can't participate are not provided.

Inclusion Criteria

I am over 18 and advised to have a nerve block for my cough.
I am over 18 and getting checked for voice issues.
I am over 18 and do not have a cough.
See 1 more

Exclusion Criteria

I have an open wound on my neck, including a tracheostomy.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo ultrasound-guided procedures such as superior laryngeal nerve block, injection laryngoplasty, and evaluations for swallowing and voice

1 day
1 visit (in-person)

Follow-up

Participants are monitored for changes in volume of injectate and patient comfort measures

4 weeks
1 visit (in-person)

What Are the Treatments Tested in This Trial?

Interventions

  • Ultrasound
Trial Overview The trial is testing the use of ultrasound in routine office procedures for patients with laryngeal conditions. It will evaluate how helpful and practical ultrasound is during nerve blocks, injection treatments into the vocal cords, and voice/swallow assessments.
How Is the Trial Designed?
6Treatment groups
Experimental Treatment
Group I: Vocal Cord ParesisExperimental Treatment1 Intervention
Group II: Vocal Cord ParalysisExperimental Treatment1 Intervention
Group III: Vocal Cord AtrophyExperimental Treatment1 Intervention
Group IV: DysphoniaExperimental Treatment1 Intervention
Group V: DysphagiaExperimental Treatment1 Intervention
Group VI: CoughExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Weill Medical College of Cornell University

Lead Sponsor

Trials
1,103
Recruited
1,157,000+

Published Research Related to This Trial

Patients who received bedside ultrasound (US) reported significantly higher satisfaction scores in overall emergency department care, diagnostic testing, and their perception of the emergency physician compared to those who did not receive US, based on a study of 70 patients over 10 months.
The use of bedside US not only expedited care and diagnosis but also enhanced the patient-physician relationship, highlighting its importance in improving patient satisfaction in healthcare settings.
Bedside ultrasound maximizes patient satisfaction.Howard, ZD., Noble, VE., Marill, KA., et al.[2022]
This case highlights the successful use of oral administration of the ultrasound contrast agent SonoVue for diagnosing a pharyngoesophageal tumor in a patient with a cervical mass, which is a novel application not widely documented in medical literature.
The diagnosis was further validated through barium swallow imaging and an endoscopy-guided biopsy, demonstrating the efficacy of SonoVue in enhancing sonographic examination for better diagnostic accuracy.
Ultrasound contrast agent delivered per os first diagnoses pharyngoesophageal tumour.Antypa, E., Cokkinos, DD., Kalogeropoulos, I., et al.[2019]
Therapeutic ultrasound has been shown to significantly reduce pain intensity in patients with neck pain compared to sham or no treatment, based on a review of 12 randomized controlled trials involving 705 patients.
The safety profile of therapeutic ultrasound is favorable, as no adverse events were reported; however, its effectiveness when combined with other treatments for improving disability or quality of life remains unclear due to high variability in study results.
Effect of Therapeutic Ultrasound for Neck Pain: A Systematic Review and Meta-Analysis.Qing, W., Shi, X., Zhang, Q., et al.[2021]

Citations

Bedside ultrasound maximizes patient satisfaction. [2022]
Ultrasound contrast agent delivered per os first diagnoses pharyngoesophageal tumour. [2019]
Effect of Therapeutic Ultrasound for Neck Pain: A Systematic Review and Meta-Analysis. [2021]
Ultrasound in speech therapy with adolescents and adults. [2019]
A Novel Assessment Method With Ultrasound for Obstructive Tonsillar Hypertrophy in Children. [2021]
Diagnostic ultrasound equipment. Safety and dosimetry. [2005]
The safety of deFinity and Optison for ultrasound image enhancement: a retrospective analysis of 78,383 administered contrast doses. [2022]
[Technical safety in ultrasound diagnosis]. [2006]
Knowledge of the bio-effects of ultrasound among physicians performing clinical ultrasonography: Results of a survey conducted by the Italian Society for Ultrasound in Medicine and Biology (SIUMB). [2021]
Safety of ultrasound contrast agents. [2020]
An update on the use of ultrasound imaging in oral and maxillofacial surgery. [2022]
Ultrasonography of the larynx: Novel use during the SARS-CoV-2 pandemic (Review). [2021]
Laryngeal ultrasonography in infants and children: a new way of investigating. Normal and pathological findings. [2019]
14.United Statespubmed.ncbi.nlm.nih.gov
Head and neck ultrasound: why now? [2016]
[Sonography of the larynx in childhood: new perspectives due to the use of computerized sonography. 1: Anatomy and method]. [2006]
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