MTR-601 for Torticollis
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests MTR-601, a new treatment for cervical dystonia, which causes painful neck muscle spasms. The study will assess the safety and effectiveness of MTR-601 by comparing it to a placebo (a non-active treatment). Suitable participants have experienced cervical dystonia for some time, have previously tried botulinum toxin injections, and are willing to avoid these injections during the study. This trial may interest those seeking alternative treatments for their condition. As a Phase 2 trial, the research measures the treatment's effectiveness in an initial, smaller group, offering participants a chance to explore new treatment options.
Do I need to stop taking my current medications for the trial?
The trial requires that you stop using certain medications, such as botulinum toxin and specific drugs that interact with MTR-601, for a specified period before and during the study. However, some treatments for cervical dystonia, like muscle relaxants and benzodiazepines, are allowed if the dose has been stable for at least 3 months.
Is there any evidence suggesting that MTR-601 is likely to be safe for humans?
Research has shown that MTR-601 is being tested for safety and effectiveness in treating cervical dystonia, a condition causing neck muscles to tighten uncontrollably. Although detailed safety data is not yet available, the current trial phase indicates that MTR-601 showed promise in earlier studies. This phase focuses on assessing how well participants tolerate the drug and identifying any side effects.
Treatments reaching this phase have typically been tested in small groups to check for major safety issues, suggesting that MTR-601 is likely considered safe enough for more extensive testing. However, participants should be aware that side effects can occur, and the study will closely monitor for any negative reactions.12345Why do researchers think this study treatment might be promising for torticollis?
Most treatments for torticollis involve muscle relaxants or botulinum toxin injections to ease muscle spasms. But MTR-601 works differently, as it targets the underlying neurological signals that cause the muscle contractions. This unique mechanism could offer more sustained relief without the need for frequent injections. Researchers are excited because this approach may lead to longer-lasting improvements and fewer side effects compared to current options.
What evidence suggests that MTR-601 might be an effective treatment for cervical dystonia?
Research shows that MTR-601, which participants in this trial may receive, may help treat cervical dystonia, a condition where neck muscles tighten uncontrollably. Previous studies used a special scale to measure the severity of the condition. Early results indicated that people taking MTR-601 had fewer symptoms than those taking a placebo. This suggests that MTR-601 might help reduce muscle spasms and discomfort linked to cervical dystonia. Although more research is needed, these early findings offer promise for those seeking relief.15678
Are You a Good Fit for This Trial?
This trial is for adults aged 18-75 with cervical dystonia, experiencing disability and pain. Participants must have been on a stable botulinum toxin treatment for over a year but agree not to use it during the study. They should weigh at least 40 kg with a BMI of ≤35 and commit to effective birth control during and after the trial.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either MTR-601 or placebo daily for 4 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- MTR-601
Find a Clinic Near You
Who Is Running the Clinical Trial?
Motric Bio
Lead Sponsor