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Phytochemical

Curcumin for Prostate Cancer

Phase 3
Recruiting
Led By Yair Lotan, MD
Research Sponsored by University of Texas Southwestern Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Biopsy proven, low-risk, localized prostate cancer (minimum of 8 cores)
Age between 40-89 years
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 years
Awards & highlights

Study Summary

This trial will test whether the spice curcumin can help prevent cancer progression in men with prostate cancer.

Who is the study for?
Men aged 40-89 with low-risk, localized prostate cancer (Gleason score ≤6, PSA ≤15 ng/ml) who haven't had previous prostate cancer treatments can join. They should have a life expectancy over 5 years and not be on certain blood thinners or drugs affecting hormones, nor have serious gastric issues or gallbladder problems unless resolved by surgery.Check my eligibility
What is being tested?
The study is testing if curcumin (a compound found in turmeric) can prevent the progression of prostate cancer compared to a placebo in patients under active surveillance. Participants will be randomly assigned to either receive curcumin or a placebo.See study design
What are the potential side effects?
Curcumin may cause digestive upset like stomach pain, nausea, diarrhea; it could also increase bleeding risk especially if combined with blood-thinning medications.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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My prostate cancer is low-risk and confirmed by biopsy.
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I am between 40 and 89 years old.
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I had a biopsy in the last year with ≤4 cancerous cores.
Select...
My cancer is in an early stage, but not the earliest.
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My prostate cancer has a low Gleason score without aggressive patterns.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
The primary end point is rate of disease progression.

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: CurcuminActive Control1 Intervention
Other names for the supplement: BCM-95 CG (Biocurcumax),Tumeric Manufacture- DolCas Biotech, LLC. Classification - type of agent: Supplement Protocol dose: 500 mg twice
Group II: PlaceboPlacebo Group1 Intervention
Drug: placebo placebo orally twice a day Other Names: •sugar pill

Find a Location

Who is running the clinical trial?

University of Texas Southwestern Medical CenterLead Sponsor
1,043 Previous Clinical Trials
1,053,259 Total Patients Enrolled
15 Trials studying Prostate Cancer
1,844 Patients Enrolled for Prostate Cancer
Yair Lotan, MD5.09 ReviewsPrincipal Investigator - UT Southwestern Medical Center
Texas Health Hospital Frisco, William P. Clements Jr. University Hospital
Medical School - Justus-Liebig-Universität Giessen Fachbereich Medizin
German Army Hospital, Residency in Urological Surgery
8 Previous Clinical Trials
2,940 Total Patients Enrolled
1 Trials studying Prostate Cancer
608 Patients Enrolled for Prostate Cancer
5Patient Review
The experience was good. It was quick and easy.

Media Library

Curcumin (Phytochemical) Clinical Trial Eligibility Overview. Trial Name: NCT03769766 — Phase 3
Prostate Cancer Research Study Groups: Curcumin, Placebo
Prostate Cancer Clinical Trial 2023: Curcumin Highlights & Side Effects. Trial Name: NCT03769766 — Phase 3
Curcumin (Phytochemical) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03769766 — Phase 3

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many people have been approached to join this clinical trial?

"That is correct, the online information hosted on clinicaltrials.gov affirms that this research is actively looking for volunteers. The trial was established on March 11th, 2019 and the most recent update was on September 26th, 2020.291 individuals are needed for the study taking place at a single site."

Answered by AI

Are there presently opportunities for new volunteers in this trial?

"The latest information from clinicaltrials.gov seems to show that this trial is still actively looking for participants. This trial was first posted on March 11th, 2019 and was updated as recently as September 26th, 2020. They are looking to enroll 291 people total at 1 location."

Answered by AI

Does this research include people who are octogenarians or younger?

"Individuals who are over the age of 40 and under 89 years old are being recruited for this study."

Answered by AI

What is the evidence that Curcumin is effective?

"Curcumin, which is being trialed in 21 locations, has 17 ongoing clinical trials with 3 in Phase 3. A majority of these studies are based in Farmington Hills, Michigan."

Answered by AI

Has Curcumin received the official green light from the FDA?

"Curcumin has been given a safety rating of 3. This is based on it being a phase 3 trial, which means that while there is data supporting efficacy, there are also multiple rounds of data supporting safety."

Answered by AI

How can I volunteer for this experiment?

"To be eligible for this prostate cancer study, men must be between 40 and 89 years old. Currently, there are 291 open spots for volunteers."

Answered by AI
~99 spots leftby Nov 2026