Curcumin for Prostate Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This is a prospective study to determine if the use of curcumin randomized against placebo will reduce cancer progression in patients with prostate cancer undergoing active surveillance.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop all current medications, but you cannot participate if you are taking certain medications like 5α-reductase inhibitors, anabolic steroids, or drugs with antiandrogenic properties. If you are taking Curcumin, you must be willing to stop.
Is curcumin safe for human use?
How is curcumin different from other prostate cancer treatments?
Curcumin, a natural compound found in turmeric, is unique because it can inhibit growth and promote cell death in prostate cancer cells by affecting specific signaling pathways, such as NF-κB and epidermal growth factor receptor (EGF-R). Unlike traditional hormone therapies or surgeries, curcumin offers a natural alternative with potential chemopreventive properties.35678
What evidence supports the effectiveness of the treatment Curcumin for prostate cancer?
Research shows that curcumin, a natural compound found in turmeric, can inhibit the growth of prostate cancer cells and induce cell death (apoptosis) in both laboratory and animal studies. It has been found to enhance the effects of other treatments, like TRAIL, in making cancer cells more susceptible to treatment.567910
Who Is on the Research Team?
Yair Lotan, MD
Principal Investigator
UT Southwestern Medical Center
Are You a Good Fit for This Trial?
Men aged 40-89 with low-risk, localized prostate cancer (Gleason score ≤6, PSA ≤15 ng/ml) who haven't had previous prostate cancer treatments can join. They should have a life expectancy over 5 years and not be on certain blood thinners or drugs affecting hormones, nor have serious gastric issues or gallbladder problems unless resolved by surgery.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either curcumin or placebo to evaluate its effect on reducing cancer progression
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Curcumin
- Placebo
Curcumin is already approved in United States, European Union, India, China for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Texas Southwestern Medical Center
Lead Sponsor