walnuts for Prostate Cancer

Phase-Based Estimates
Cedars-Sinai Medical Center, Los Angeles, CA
Prostate Cancer+2 More
walnuts - Other
Eligible conditions
Prostate Cancer

Study Summary

This study is evaluating whether walnut consumption may have positive impacts for individuals with prostate cancer.

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Eligible Conditions

  • Prostate Cancer
  • Prostatic Neoplasms
  • Weight Loss

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether walnuts will improve 1 primary outcome and 2 secondary outcomes in patients with Prostate Cancer. Measurement will happen over the course of 10 weeks.

10 weeks
Mean difference in prostatic tissue Ki67 expression from baseline biopsy to RP
Mean difference in prostatic tissue inflammation from baseline biopsy to RP
Mean difference in prostatic tissue oxidative stress from baseline biopsy to RP

Trial Safety

Safety Estimate

2 of 3
This is better than 68% of similar trials

Trial Design

2 Treatment Groups

Usual Diet
Usual Diet + Walnuts

This trial requires 50 total participants across 2 different treatment groups

This trial involves 2 different treatments. Walnuts is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.

Usual Diet + WalnutsUsual diet with the addition of two ounces of walnuts daily, phone counseling with dietitian, for 4-10 weeks
Usual Diet
Usual diet for 4-10 weeks

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 10 weeks
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 10 weeks for reporting.

Closest Location

Cedars-Sinai Medical Center - Los Angeles, CA

Eligibility Criteria

This trial is for male patients aged 18 and older. There are 7 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Diagnostic biopsy cores with ≥10 cores with each core examined separately to determine exact tumor location.
Pathologically confirmed prostate adenocarcinoma.
Biopsy grade group 2 or higher (Gleason ≥7).
Planning to undergo RP.
Willing to adhere to a usual diet with the possible addition of 2 oz of walnuts per day.
Reads, writes, and understands English.
Age 18 or older

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the signs of prostate cancer?

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Men with [prostate cancer](https://www.withpower.com/clinical-trials/prostate-cancer) have increased circulating testosterone levels, increased free prostate-specific antigen or elevated prostate-specific antigen/total prostate-specific antigen ratio. These are the only findings on physical examination suggestive of prostate cancer. We recommend that a biopsy be performed in such men. However, we have found no other findings which would exclude a diagnosis of prostate cancer. There is no evidence for increased serum prostate-specific antigen in any other condition. If serum prostate-specific antigen is elevated then further measurements may be useful in excluding prostate cancer.

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What causes prostate cancer?

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The major risks factor for prostate cancer are: advancing age; high grade Gleason score; high PSA; family history of prostate cancer; and a personal history of prostate cancer.

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What is prostate cancer?

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Prostate cancer (PCa) is a devastating disease that typically appears in older men, especially those over the age of 50. It is a disease that forms in the lining of the prostate and can occur at any time in an individual's life. However, PCa is not the main cause of morbidity and mortality in older men; the primary causes are cardiovascular diseases and chronic and degenerative conditions of the genitourinary tract. PCa has a very poor prognosis, even with surgical treatment. Patients with PCa have a high risk of developing life-threatening complications, including bleeding and heart attacks.

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What are common treatments for prostate cancer?

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We summarize the most commonly used treatments for [prostate cancer](https://www.withpower.com/clinical-trials/prostate-cancer) and include the patient's overall health and the severity of each cancer's treatment requirements into the picture.

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How many people get prostate cancer a year in the United States?

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The most recent estimate indicates that 5,600 to 10,000 men in the U.S. were diagnosed with prostate cancer during 1999. Based on these estimates, about 1.7 million men were diagnosed with prostate cancer during 1999. Among men and survivors, prostate cancer prevalence declined by 29 percent between 1979 and 2003.

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Can prostate cancer be cured?

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In the absence of alternative treatments, early detection and aggressive management in the asymptomatic setting are the best forms of prevention, and they may reduce metastatic spread to distant sites.

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What does walnuts usually treat?

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Walnuts are the second most common herbal supplement used to treat prostate cancer after soy, based on a cross-sectional design review. The current literature suggests that walnuts are safe and may be effective for prostate cancer. Further investigation is necessary to assess the effect of walnuts in people with existing prostate cancer. Current results of prospective studies are awaited. Current evidence suggests that walnuts have a role in managing prostate cancer, because it lowers PSA and slows the progression of prostate cancer.

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What is the latest research for prostate cancer?

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In light of the limitations of the reviews, we conclude that there is a lot of promise in [prostate cancer](https://www.withpower.com/clinical-trials/prostate-cancer) research. In particular, the area of prostate specific antigen testing has seen some breakthrough research. It remains challenging however to determine whether the findings will translate into an altered paradigm in prostate cancer management.

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How does walnuts work?

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Ingestion of walnuts is an important preventive strategy against prostate cancer. In a recent study, findings provide insight into the molecular basis of this protection and highlight the importance of developing prostate cancer prevention strategies, particularly considering the increasing incidence of prostatitis caused by probiotic bacteria, as many of our patients are being provided with probiotic-containing probiotics, either for or against treatment of prostate cancer.

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Have there been other clinical trials involving walnuts?

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The current data do not support the use of walnut oil (150 or 300 g/day) in the treatment of [prostate cancer](https://www.withpower.com/clinical-trials/prostate-cancer). Whether walnut oil has any pharmacological role in treating prostate disease requires further investigation.

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What are the latest developments in walnuts for therapeutic use?

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Walnut products may have potential for use in prostate disease and are worthy of further investigation. We discuss the rationale for these investigations by comparing the various properties of walnut components and walnut preparations with their potential anti-prostatic effects.

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What are the chances of developing prostate cancer?

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The odds of developing [prostate cancer](https://www.withpower.com/clinical-trials/prostate-cancer) in men who had prostate biopsy depend on the level of PSA, age, race, ethnicity, and family history. Men with a family history of prostate cancer in their first-degree male relatives have a 5x greater incidence of developing prostate cancer at a later age and a 10x greater incidence after the age of 70.

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