5 Participants Needed

RFA for Thyroid Cancer

MS
VM
Overseen ByVishakantha Murthy, PhD, MBA
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to test the effectiveness of using heat from radio waves to treat small thyroid cancers. It will focus on patients with small papillary thyroid carcinoma and will monitor changes in tumor size and other health indicators after treatment. Radiofrequency ablation (RFA) has been studied as a treatment for small papillary thyroid microcarcinomas, particularly in patients who are ineligible for surgery.

Who Is on the Research Team?

MS

Marius Stan, MD

Principal Investigator

Mayo Clinic

Are You a Good Fit for This Trial?

This trial is for adults with a small papillary thyroid carcinoma (less than 1.5 cm) that can be treated without surgery, as decided by their doctor and radiologist. It's not for those with widespread cancer, pregnant women, individuals who have difficult neck anatomy for RFA access, high anesthesia risk due to other illnesses, recent investigational drug use, substance abuse issues, blood clotting disorders or prior neck treatments.

Inclusion Criteria

I am 18 years old or older.
Diagnosed using fine needle aspiration (FNA) testing.
My scans show I can have RFA therapy with low risk.
See 3 more

Exclusion Criteria

My opposite side vocal cord is paralyzed.
Pregnancy
My cancer has spread to other parts of my body.
See 7 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo radiofrequency ablation (RFA) therapy for papillary thyroid carcinoma

1 day
1 visit (in-person)

Follow-up

Participants are monitored for changes in primary tumor volume, lymph node involvement, distant metastasis, and serum thyroid hormone levels

18 months
Regular visits (in-person)

What Are the Treatments Tested in This Trial?

Interventions

  • RFA
Trial Overview The study is testing Radiofrequency Ablation (RFA), which uses heat to destroy cancer cells in treating papillary thyroid carcinoma. The goal is to see how effective RFA is at eliminating the tumor while minimizing risks.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: RFA GroupExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Mayo Clinic

Lead Sponsor

Trials
3,427
Recruited
3,221,000+
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