Mindfulness Therapy for Heroin Addiction
(MORE Trial)
Trial Summary
What is the purpose of this trial?
In this study, neuroimaging of reward processing, drug cue reactivity and inhibitory control is used before and immediately after 8 weeks of two types of group therapy in individuals with opioid addiction; clinical outcomes will be assessed before, immediately and three months after treatment. Results could point to factors that track and predict recovery with treatment, offering clinicians markers that can be used for enhancing precision medicine with the goal of reducing morbidity and mortality associated with opiate addiction.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but it requires participants to be stabilized on methadone or another form of medication-assisted treatment (MAT).
What data supports the effectiveness of the treatment Mindfulness-Oriented Recovery Enhancement (MORE) for heroin addiction?
Research shows that Mindfulness-Oriented Recovery Enhancement (MORE) is effective in helping people recover from opioid use disorder, which includes heroin addiction. It combines mindfulness training, cognitive behavioral therapy, and positive psychology to support recovery and has shown positive effects in reducing substance use and improving well-being.12345
Is Mindfulness-Oriented Recovery Enhancement (MORE) safe for humans?
How is the Mindfulness-Oriented Recovery Enhancement treatment different from other treatments for heroin addiction?
Mindfulness-Oriented Recovery Enhancement (MORE) is unique because it combines mindfulness training, cognitive behavioral therapy (CBT), and positive psychology to address both addiction and related issues like chronic pain. Unlike standard treatments, MORE focuses on enhancing emotional regulation and well-being, making it a comprehensive approach to recovery.23457
Research Team
Rita Goldstein, PhD
Principal Investigator
Icahn School of Medicine at Mount Sinai
Nelly Alia-Klein, PhD
Principal Investigator
Icahn School of Medicine at Mount Sinai
Eligibility Criteria
This trial is for adults aged 18-64 with heroin addiction, specifically those who have chosen heroin as their primary drug and are stabilized on methadone or similar treatments. It's not suitable for individuals with metal implants, serious medical conditions like heart disease, a history of significant head trauma, neurological diseases, schizophrenia, autism spectrum disorders, or infectious diseases such as Hepatitis B/C or HIV/AIDS.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo 8 weeks of group therapy, with neuroimaging assessments conducted immediately before and after treatment
Follow-up
Participants are monitored for clinical outcomes and undergo neuroimaging assessments 3 months after treatment
Treatment Details
Interventions
- Behavioral group therapy #1
- Behavioral group therapy #2
- Mindfulness-Oriented Recovery Enhancement (MORE)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Icahn School of Medicine at Mount Sinai
Lead Sponsor
National Center for Complementary and Integrative Health (NCCIH)
Collaborator
University of Utah
Collaborator