Treatment for Arthrosis

Phase-Based Estimates
1
Effectiveness
1
Safety
University of Chicago Medicine, Chicago, IL
Arthrosis+1 More
Eligibility
18+
All Sexes
Eligible conditions
Arthrosis

Study Summary

Variable Immobilization Protocol for Arthroplasty of the Carpometacarpal Joint of the Thumb

See full description

Eligible Conditions

  • Arthrosis
  • Osteoarthritis
  • Osteoarthritis Thumbs

Treatment Effectiveness

Study Objectives

This trial is evaluating whether Treatment will improve 1 primary outcome and 2 secondary outcomes in patients with Arthrosis. Measurement will happen over the course of Change from baseline quickDASH to 3-months.

Change from baseline PROMIS to 3-months
Patient-Reported Outcome Measures Information System (PROMIS) Upper Extremity scores
Change from baseline VAS to 3-months
Visual Analog Scale (VAS) Pain scale
Change from baseline quickDASH to 3-months
Quick Disabilities of Arm, Shoulder, and Hand (quickDASH) Questionnaire scores

Trial Safety

Trial Design

2 Treatment Groups

2 weeks of immobilization

This trial requires 90 total participants across 2 different treatment groups

This trial involves 2 different treatments. Treatment is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

2 weeks of immobilization
Other
Subjects randomized to this arm will be rigidly immobilized in a plaster postoperative thumb spica splint for 2 weeks following their thumb CMC arthroplasty
6 weeks of immobilization
Other
Subjects randomized to this arm will be rigidly immobilized in a plaster postoperative thumb spica splint, transitioned to cast, for a total of 6 weeks following their thumb CMC arthroplasty

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: change from baseline vas to 3-months
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly change from baseline vas to 3-months for reporting.

Closest Location

University of Chicago Medicine - Chicago, IL

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 4 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Suspensionplasty is a type of surgery that is used to treat drooping eyelids show original
People who are 40 years old or older are considered to be of age. show original
Trapeziectomy with LRTI
Simple Trapeziectomy

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the primary cause of arthrosis?

Add answer

Arthrosis of the shoulder can have many causes including traumatic shoulder injuries which have a good prognosis for healing and non-traumatic causes which are not always very favorable in their prognosis.

Unverified Answer

What is the average age someone gets arthrosis?

Add answer

About half of patients had knee pain in both knees before the age of 40 years, and about half of patients had more joint dysfunction over time. Further research is needed to understand the role of age in causation of osteoarthritis.

Unverified Answer

What causes arthrosis?

Add answer

Arthrosis generally has no identifiable cause; however, some conditions can cause pain or tenderness in adjacent joints without an obvious cause such as arthritis in this case. A careful medical history and physical examination are the most important steps to obtaining a definitive diagnosis of arthrosis.

Unverified Answer

What is arthrosis?

Add answer

Arthrosis can be summarized as arthritis of joints that occurs without an obvious medical condition or injury. The different kinds of articular arthritis include gout, psoriatic, SAPHO syndrome, and rheumatoid. Although common, there are fewer than 4% of cases worldwide.

Unverified Answer

How many people get arthrosis a year in the United States?

Add answer

An estimated 18 million adults aged 20 to 39 years were affected by the disorder in 2006. Most cases have a history of sports-related overuse of the affected joint but many women are first suspected of having the arthrosis after an x-ray is obtained for other reasons in the clinic.

Unverified Answer

What are the signs of arthrosis?

Add answer

Arthrosis can cause excessive stiffness in the joints, which causes pain in the whole joint, which can be relieved temporarily with exercise that activates the muscles and by use of NSAIDS. Arthrosis can lead to the formation of bony spur in the joint, which can cause pain in the joint.

Unverified Answer

Can arthrosis be cured?

Add answer

The findings of this study suggest that arthrosis is a chronic disease affecting multiple joints. The treatments in this pilot study did not produce the desired results.

Unverified Answer

What are common treatments for arthrosis?

Add answer

The most common treatments included braces, pain medications, and physical therapy. Braces are most frequently prescribed because they are less invasive. Medication and physical therapy were provided as additional treatments.

Unverified Answer

Have there been other clinical trials involving treatment?

Add answer

It is evident that many more small phase II/III studies are needed to find new treatment options for arthritis. While these studies are usually well-designed, they are still often of limited power. This is due to the need not to be blinded and to use a large percentage (30 to 50%) of as-yet-unavailable patients in the placebo arm. The problem here is how to best design the studies. Clearly, we need trials of high power. It would be ideal to use a large number of patients as subjects, but this would require many years' notice. The aim here is to start trials earlier. The need to be as blind as possible will, however, limit this approach.

Unverified Answer

Is treatment safe for people?

Add answer

For those with arthritis, the risks and benefits of glucocorticoids have been well described and guidelines and treatment algorithms are available. However, an international database of patients found that glucocorticoids may be more harmful for people with osteoporosis than those without osteoporosis. This highlights the value of considering both bone loss and bone strength when using glucocorticoids in rheumatic diseases and also the need for further research on the safety and benefits of glucocorticoid therapies in patients with osteoporosis.

Unverified Answer

What does treatment usually treat?

Add answer

The [ClinicalTrials.gov] database lists over 4000 clinical trials for the treatment of [osteoarthritis](https://www.withpower.com/clinical-trials/oste[oa](https://www.withpower.com/clinical-trials/oa)rthritis), and each of them has the potential to identify new treatments for people with arthritis. But, because these databases do not provide data about how often treatments are used, it's hard to tell whether these therapies and the treatments they're used for are effective. To find new treatments for OA, there's an open question: 'What treatments are used by most OA patients?' This question cannot be answered well because there's no way to collect data that lists the many treatments being used in real-world settings.

Unverified Answer

Has treatment proven to be more effective than a placebo?

Add answer

The studies are insufficiently homogenous, but it seems that there is no difference of effects between glucosamine sulfate and the placebo, as judged on the change of the KOOS scores in studies where patients received either treatment or a placebo. The studies are inconclusive concerning the effect of glucosamine sulfate on chondrocyte viability and the effect on pain or functional progress. In order to be conclusive, a larger trial using the most relevant patient populations would be needed.

Unverified Answer
See if you qualify for this trial
Get access to this novel treatment for Arthrosis by sharing your contact details with the study coordinator.