CLINICAL TRIAL

Micro Fragmented Adipose Tissue for Arthrosis

Waitlist Available · 18+ · All Sexes · Stanford, CA

This study is evaluating whether a new treatment for osteoarthritis is better than the current standard treatment.

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About the trial for Arthrosis

Eligible Conditions
Shoulder Pain · Osteoarthritis · Osteoarthritis of the Shoulder

Treatment Groups

This trial involves 2 different treatments. Micro Fragmented Adipose Tissue is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 1 and are in the first stage of evaluation with people.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Micro Fragmented Adipose Tissue
PROCEDURE
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.
Corticosteroid injection
PROCEDURE

Eligibility

This trial is for patients born any sex aged 18 and older. There are 8 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Age between 25 and 75 years-old
Able to complete online, in-person or phone surveys for the purposes of follow-up
Capable of understanding pre- and post-procedure care instructions
Previous trial and failure of conservative therapy consisting of a minimum of 6 weeks of physical therapy and trial of anti-inflammatory medications if not contraindicated, with or without concomitant bracing and/or injections.
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial

Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: 24 Months
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: 24 Months.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Micro Fragmented Adipose Tissue will improve 1 primary outcome and 2 secondary outcomes in patients with Arthrosis. Measurement will happen over the course of 24 Months.

DASH Outcome Measure
24 MONTHS
Patient reported questionnaire that measures physical function and symptoms
ASES Shoulder Score
24 MONTHS
Patient reported outcome measure that reports shoulder pain and shoulder functionality
Veterans RAND 12 (VR-12) score
24 MONTHS
Patient reported quality of life outcome measure on a scale of 0-50 with 50 being healthy

Who is running the study

Principal Investigator
E. R.
Prof. Eugene Roh, Clinical Associate Professor
Stanford University

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are common treatments for arthrosis?

Arthrosis is managed with different combinations of analgesics, anti-chronicity medications, joint mobilisation techniques, modalities such as joint mobilization, physiotherapy, splinting therapy, extracorporeal shockwave therapy, and radio-surgical intervention with the usage of bone cement in order to immobilise joints. Patients are often managed by a physiotherapist, in which physiotherapy could be used on chronic joint pain management, which is not limited by conventional treatments.

Anonymous Patient Answer

What is arthrosis?

Arthrosis is a disease where the articular cartilage is compromised due to its breakdown within the joint and the underlying disc. Arthrosis mainly occurs in the extremities but also involves the spine.

Anonymous Patient Answer

Does micro fragmented adipose tissue improve quality of life for those with arthrosis?

Micro fragrances can improve the quality of life of patients with arthrosis through the following mechanisms: analgesic effects, increase in the size of the adipocytic tissue and a decrease in pain sensation.

Anonymous Patient Answer

How many people get arthrosis a year in the United States?

Results from a recent clinical trial shows that, among those reporting symptoms of knee or hip osteoarthritis, only about 15% had symptoms that were consistent with a diagnosis of definite or probable arthrosis on clinical examination. The prevalence of arthrosis is very low in the United States.

Anonymous Patient Answer

What are the signs of arthrosis?

There are no "gold standard" signs of joint arthrosis, but some "basic" signs are: no pain, no swelling, and there should always be a "worrying history". The signs of early arthrosis often get better when the patient uses their hands and/or moves their back.

Anonymous Patient Answer

What causes arthrosis?

The pathogenesis of arthrosis still remains unknown; it is believed that both age and sex play an important role. Some evidence suggests that the body responds to traumatic injury with reactive ossification of the joints.

Anonymous Patient Answer

Can arthrosis be cured?

Although the results of this case report are not the first reported of successful arthroplasty in individuals with a symptomatic, degenerative joint disease, we believe this report highlights the potential of orthopedic surgery to help a number of patients suffering from symptomatic arthrosis.

Anonymous Patient Answer

Who should consider clinical trials for arthrosis?

A majority of patients who are considering clinical trials for arthritis and other inflammatory diseases will participate in clinical trials. Those with arthritis from different populations should be able to participate in different clinical trials to further assess their arthritis treatment options.

Anonymous Patient Answer

What are the common side effects of micro fragmented adipose tissue?

This is the first study to examine SFMT levels in inflamed synovial fluid, demonstrating the potential of SFMT as an "arthritis biomarker" in a clinical setting.

Anonymous Patient Answer

Have there been any new discoveries for treating arthrosis?

The treatments options (such as intra-articular injections, oral and injectable biologic treatment and physical therapy) were assessed and it was concluded that more studies have to be conducted to assess the better one for treating arthrosis. It was concluded that the only way to treat patients with arthritis effectively was to decrease the level of pain and arthritis-related disability.

Anonymous Patient Answer

What does micro fragmented adipose tissue usually treat?

FMD had good intra-relator reliability. However, a positive relation with other clinical parameters such as joint pain and stiffness could be due to the relatively low number of patients in this analysis. Given our results, we propose that FMD and MMP should be considered as potential clinical variables to include in a systematic approach to patient selection for active FMD treatment.

Anonymous Patient Answer

Does arthrosis run in families?

Arthrosis and OA occur quite commonly both in the family members and in the spouses of OA subjects without OA. We hypothesize that there may be a genetic component to OA. Because these diseases are quite common, the possibility of a genetic factor exists. An exhaustive search to find a genetic locus for OA is likely to yield positive results.

Anonymous Patient Answer
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