Ketone Supplementation for Enhancing Ketosis
(STAK: OK'd Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests different types of ketone supplements and a precursor to see how they affect metabolism. The study involves participants who meet specific health and dietary criteria. These supplements increase ketone levels in the blood, offering an alternative energy source to glucose.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but it requires that you maintain your medication habits throughout the study. If you have unstable use of a medication that might affect the trial outcomes, you may be excluded.
Is ketone supplementation safe for humans?
How does the ketone supplementation treatment differ from other treatments for enhancing ketosis?
This treatment is unique because it uses ketone esters and diesters to induce ketosis without requiring dietary changes, unlike traditional methods that rely on a high-fat, low-carbohydrate diet. It elevates blood ketone levels quickly and is generally well-tolerated, offering a practical alternative to achieve ketosis.16789
What data supports the effectiveness of the treatment Ketone Supplementation for Enhancing Ketosis?
Research shows that ketone esters, like the ones in this treatment, can increase blood ketone levels, which may help reduce seizures in epilepsy and decrease body weight and liver fat in mice. Additionally, ketone drinks have been shown to effectively induce ketosis in humans, which is linked to various health benefits.23567
Who Is on the Research Team?
Jeff S Volek, PhD
Principal Investigator
Ohio State University
Are You a Good Fit for This Trial?
This trial is for healthy males aged 20-30, with a BMI of 18-29 kg/m^2 who don't smoke or use cannabis, haven't used ketone supplements or followed a low-carb diet recently, and aren't taking part in other studies. They must be able to fast and avoid alcohol before test days.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants consume different ketone esters and precursors, with repeated blood sampling and metabolic measurements
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- AcAc Diester
- BDO
- BHB Monoester
- C6 Diester
Find a Clinic Near You
Who Is Running the Clinical Trial?
Ohio State University
Lead Sponsor
Ohio State University Comprehensive Cancer Center
Lead Sponsor