This trial is evaluating whether Leucovorin will improve 1 primary outcome and 1 secondary outcome in patients with Cancer of Rectum. Measurement will happen over the course of 3 years.
This trial requires 358 total participants across 2 different treatment groups
This trial involves 2 different treatments. Leucovorin is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.
"Of patients presenting with rectal adenocarcinoma, 14% had an ulcerative colitis (UC). The presence of ulcerative colitis was associated with synchronous [colorectal cancer](https://www.withpower.com/clinical-trials/colorectal-cancer) in both cases and patients developing new cancers after previous colorectal cancer. The synchronous or metachronous occurrence of colorectal cancer in patients with UC is of interest if the cancer of rectum is suspected. The presence of UC warrants careful attention by health professionals concerning the possible presence of colorectal cancer and evaluation for synchronous colorectal cancers, particularly in cases of colorectal carcinoma." - Anonymous Online Contributor
"About two-thirds of [colorectal cancer](https://www.withpower.com/clinical-trials/colorectal-cancer)s are rectal cancers. In the USA, the incidence of rectal cancers is about 4 times higher in males than in females. Most colon cancers in males are adenomas whereas in females they are sessile and invasive. The prognosis is worse for rectal cancers than colon cancers in males and colon cancers in females." - Anonymous Online Contributor
"Radical surgery is the only proven treatment and has the greatest impact in long-term survival in colorectal cancer patients. We propose that proton pump inhibitor, a kind of low-dose aspirin may also be effective preventive agent for colorectal cancer. The impact of radiation or chemotherapy is also controversial." - Anonymous Online Contributor
"At least 1,000 new cases arise each year in the United States, of which nearly 750,000 were [colo[rectal cancer](https://www.withpower.com/clinical-trials/rectal-cancer)](https://www.withpower.com/clinical-trials/colorectal-cancer). The most common of the rectal cancers is one of the most common types; the most frequent in males and the most common in the elderly; and the rates of these cancers are low in young and middle aged persons. Rectal cancers occur with a higher frequency in persons on the white side of the racial divide." - Anonymous Online Contributor
"Dyspareunia is common in rectal cancer. Rectal mass and perineal pain would be very suggestive of this condition. Tumor markers such as CEA and CA125 can help in making this diagnosis." - Anonymous Online Contributor
"Even if there were no cure for rectal cancer it would still represent a cure for colorectal cancer as the cure for colorectal cancer is the cure for rectal cancer. The cure for rectal cancer is not feasible." - Anonymous Online Contributor
"Adding leucovorin to a standard chemotherapy regimen for patients with disease of the rectum, as compared with a placebo, was associated with worse QOL and increased side effects. This confirms the importance of identifying effective chemopreventive treatments for cancer patients." - Anonymous Online Contributor
"Results from a recent clinical trial shows that the incidence of [colorectal cancer](https://www.withpower.com/clinical-trials/colorectal-cancer) is increasing and that the disease can invade lymphatic vessels and tumor cells spread along the lymph nodes. This cancer has a poor prognosis from the time of its onset, and also from the time of operation." - Anonymous Online Contributor
"Genetic analysis of people with rectal cancer indicates that the rectal neoplasia is likely due to multiple genetic defects; the most common type is a predisposition to polyposis intestinalis, with a second modifier gene, presumably epigenetic, underlying sporadic disease." - Anonymous Online Contributor
"There were no reports of other clinical research involving leucovorin. We urge patients to report side effects to [the prescribing doctor], [a health centre] or the UPCR, through the Contact Numbers and other sources available." - Anonymous Online Contributor
"This retrospective study revealed that cancer of rectum might spread more quickly than colon cancer. However, there was no difference between colon and rectosigmoid cancers in tumor stage at the time of resection or in the presence of nodal or distant tumor. In view of our limited sample size, these results need confirmation with larger samples." - Anonymous Online Contributor
"Risk of developing [rectal cancer](https://www.withpower.com/clinical-trials/rectal-cancer) increases by age. Risk of rectal cancer in males is higher than in females, which suggests different predisposition (or environmental factors) in males and females. Risk of developing an intrastructal carcinoma is significantly higher in smokers. These statistics confirm and refine the results of [Hepatorenal cancer in relation to occupation]] (2011), with a statistically significant risk for women employed in the services (health and social), self-employed (managers), and sales workers (sales)." - Anonymous Online Contributor