Browse 54 Dasatinib Medical Studies Across 336 Cities
5 Phase 3 Trial · 1043 Dasatinib Clinics
People take dasatinib, under the brand name SPRYCEL, to act as a cancer blocker for Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML). Both adults and children take it.
What Are Dasatinib Clinical Trials?
There was a Phase 3 trial that started in June 2007 and the first results were posted in March 20017. The final results were posted in February 2017. It was sponsored by Bristol-Myers Squibb and there were 547 participants. They were randomly allocated, assigned in a parallel manner and there was no masking - it was open label.The patients were either given Dasatinib or the usual treatment - Imatinib. Both of these were in pill form.
These participants were given pretreatment every three months for up to a year. They were all newly diagnosed with Ph+ CML. They were looking for patients to have Major Molecular Response, Complete Cytogenic Response, and they also looked at the bone marrow of these participants.
Why Is Dasatinib Being Studied In Clinical Trials?
Researchers were looking for things to help people who were diagnosed with PH + CML and were looking for treatment. They wanted something that could be better than Imantinib.
How Does Dasatinib Treatment Work?
People can take dasatinib once a day at the same time - it does not matter if it is day or night. They can also take it with or without food. It is important that the pill is swallowed whole and is not crushed or chewed. It should be taken on a continual basis - the only time that it should be stopped is if the symptoms get worse over the course of that time.
There are some possible expected side effects.Taking it can make people feel more fatigued than usual. They may have headaches or muscle or joint aches, skin rashes, and they may also feel weaker. If they start feeling depressed after taking it, then they should talk to their doctor about this side effect.
When it comes to food or drinks, they should avoid grapefruit, grapefruit juice, St. John's wort, and medications like verapamil, ketoconazole, rifampin, phenytoin, and modafanil. Patients might need to monitor their sugar as well, since they might find themselves feeling hypoglycemic while taking it due to an increased metabolic effect.
Should someone decide to stop taking this, especially before their Ph + CML has gone into remission, then they risk it going from chronic to a blast stage where their symptoms will get worse and reduce their life expectancy even more.
What Are Some of the Breakthrough Clinical Trials Involving Dasatinib?
The aforementioned clinical trial is what helped Dasatinib get it to market and help people who have Ph + CML have a better quality.
Who Are The Key Opinion Leaders On Dasatinib Clinical Trial Research?
The National Library of Medicine published a study about Dasatinib. Ultimately, Dasatinib is something that can help the molecular response of people who have Ph + CML and can help improve their test results and improve the quality of their life.