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Senolytic

Older Lean Group for Obesity

Phase 2 & 3
Recruiting
Led By Nicolas Musi, MD
Research Sponsored by The University of Texas Health Science Center at San Antonio
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up week 4 and week 15
Awards & highlights

Study Summary

This trial will involve taking samples of fat tissue from the abdomen of all participants to study their cells and molecules. The participants will also undergo tests to measure their insulin sensitivity, glucose tolerance, and function of

Who is the study for?
This trial is for lean individuals aged 18-30 or those over 65 with a healthy BMI, from any race and living in the community. They must be sedentary, nondiabetic, not pregnant or breastfeeding, and willing to use effective contraception. Participants should have normal blood sugar levels and ECG readings.Check my eligibility
What is being tested?
The study tests how lifestyle changes compare to senolytics (Dasatinib plus Quercetin) versus placebo in older obese adults. It involves baseline biopsies of belly fat for cellular analysis and checks on insulin sensitivity, glucose tolerance, and β-cell function.See study design
What are the potential side effects?
Possible side effects include reactions at the biopsy site like pain or bruising; Dasatinib may cause immune system issues or bleeding problems; Quercetin could lead to headaches or tingling sensations.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~week 4 and week 15
This trial's timeline: 3 weeks for screening, Varies for treatment, and week 4 and week 15 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Glucose tolerance
Insulin sensitivity
Secondary outcome measures
Senescence-associated secretory phenotype (SASP)

Trial Design

3Treatment groups
Experimental Treatment
Group I: Younger Lean GroupExperimental Treatment1 Intervention
Participants will be aged 18-30 years and have a BMI of 18.5 - 24.9 kg/m2
Group II: Older Obese GroupExperimental Treatment5 Interventions
Participants will be over 65 years of age with a BMI of 30-39.9 kg/m2.
Group III: Older Lean GroupExperimental Treatment1 Intervention
Participants will be over 65 years of age with a BMI of 18.5 to 24.9 kg/m2
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Placebo
1995
Completed Phase 3
~2670

Find a Location

Who is running the clinical trial?

The University of Texas Health Science Center at San AntonioLead Sponsor
453 Previous Clinical Trials
91,270 Total Patients Enrolled
6 Trials studying Obesity
990 Patients Enrolled for Obesity
Cedars-Sinai Medical CenterLead Sponsor
500 Previous Clinical Trials
164,703 Total Patients Enrolled
7 Trials studying Obesity
1,044 Patients Enrolled for Obesity
National Institute on Aging (NIA)NIH
1,675 Previous Clinical Trials
28,020,725 Total Patients Enrolled
42 Trials studying Obesity
12,538 Patients Enrolled for Obesity

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How large is the participant pool in this medical study?

"Indeed, the information provided on clinicaltrials.gov indicates that this trial is actively seeking suitable candidates. It was initially posted on October 17th, 2023 and most recently updated on January 12th, 2024. The study aims to recruit a total of 160 patients from a single designated location."

Answered by AI

Are there still available slots for patients to participate in this ongoing clinical trial?

"Indeed, as indicated by the information on clinicaltrials.gov, this research study is currently seeking prospective participants. The initial posting date was recorded as October 17th, 2023 and the most recent update occurred on January 12th, 2024. A total of 160 individuals will be admitted to participate in the trial across a single designated site."

Answered by AI

Who else is applying?

What site did they apply to?
Cedars Sinai Medical Center
What portion of applicants met pre-screening criteria?
Met criteria

Why did patients apply to this trial?

Im trying to make a few bucks.
PatientReceived 1 prior treatment
Recent research and studies
clinicaltrials.govStudy
Single Nuclei RNA-seq to Map Adipose Cellular Populations and Senescent Cells in Older Subjects
Nicolas Musi, MD 2023. "Single Nuclei RNA-seq to Map Adipose Cellular Populations and Senescent Cells in Older Subjects". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05653258.
All > Dasatinib
~107 spots leftby Feb 2026
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