Liposomal Bupivacaine vs Lidocaine for Skin Graft Pain
Trial Summary
What is the purpose of this trial?
Donor site pain study comparing post-operative donor site pain and opioid consumption after use of Lidocaine, Liposomal Bupivicaine or regional nerve block for split thickness skin graft harvesting in patients with less than 20% TBSA burn wounds and less than %5 Deep partial or full thickness burn wounds.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
What data supports the effectiveness of the drug liposomal bupivacaine for skin graft pain?
Is liposomal bupivacaine generally safe for humans?
Liposomal bupivacaine is a local anesthetic that provides long-lasting pain relief and has been studied for its safety in various surgical settings. It has a favorable potency to toxicity ratio, meaning it is effective without being overly harmful, but there are concerns about potential nerve toxicity, especially when injected into nerves.14678
How does liposomal bupivacaine differ from lidocaine for skin graft pain?
Liposomal bupivacaine is unique because it provides long-lasting pain relief for up to 72 hours after a single dose, unlike traditional local anesthetics like lidocaine, which have a shorter duration of action. This makes it particularly useful for managing the intense pain associated with skin graft donor sites.123910
Eligibility Criteria
This trial is for English or Spanish speakers with less than 20% total body surface area (TBSA) burned and less than 5% deep partial/full thickness burns. It's not for those with chronic pain conditions, more extensive burns, pregnancy, or allergies to local anesthetics like lidocaine.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment Phase 1
Randomized controlled study with injection of lidocaine with epinephrine or liposomal bupivacaine at the donor site
Treatment Phase 2
All subjects receive regional anesthesia with a nerve block based on the proposed donor site location
Follow-up
Participants are monitored for pain levels and opioid consumption post-operatively
Treatment Details
Interventions
- Bupivacaine Hydrochloride
- Lidocaine Hydrochloride
- Liposomal bupivacaine
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Kansas Medical Center
Lead Sponsor