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Electrolyte Replacement

Higher vs. Lower Hemodialysate Magnesium for Kidney Failure

N/A
Waitlist Available
Led By Amit X Garg, PhD, MD
Research Sponsored by Lawson Health Research Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
The hemodialysis centre, or a group of hemodialysis centers combined into one cluster, must care for at least 15 outpatients being treated with in-centre maintenance hemodialysis.
The medical director of the hemodialysis centre must be willing for their centre to be randomized and to adopt the allocated dialysate Mg protocol as their standard solution for the duration of the trial.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up three to four years
Awards & highlights

Study Summary

This trial will test whether increasing the magnesium concentration in the dialysate can help patients on dialysis live longer and have fewer heart-related hospitalizations.

Who is the study for?
This trial is for patients undergoing in-center maintenance hemodialysis at facilities that treat at least 15 such patients. The facility's medical director must agree to use the assigned magnesium protocol throughout the study. Centers with fewer than 15 patients on conventional in-center hemodialysis are excluded.Check my eligibility
What is being tested?
The study is testing two different concentrations of magnesium in dialysate solutions used during hemodialysis: one lower (≤1.0 mEq/L) and one higher (1.5 mEq/L). It aims to see if a higher concentration can reduce deaths, heart-related hospitalizations, and muscle cramps associated with dialysis.See study design
What are the potential side effects?
While not explicitly stated, potential side effects may include issues related to abnormal magnesium levels such as weakness, confusion, blood pressure changes or irregular heartbeat; however these will be monitored closely given the nature of the intervention.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
My dialysis center treats at least 15 patients with in-center hemodialysis.
Select...
My dialysis center's director agrees to follow the trial's magnesium protocol.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~three to four years
This trial's timeline: 3 weeks for screening, Varies for treatment, and three to four years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Composite outcome of cardiovascular-related hospitalization and all-cause mortality
Secondary outcome measures
Components of the primary composite outcome
Muscle Cramp

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Higher dialysate magnesiumExperimental Treatment1 Intervention
Group II: Lower dialysate magnesiumActive Control1 Intervention

Find a Location

Who is running the clinical trial?

Lawson Health Research InstituteLead Sponsor
654 Previous Clinical Trials
388,215 Total Patients Enrolled
2 Trials studying Kidney Failure
41 Patients Enrolled for Kidney Failure
ICESIndustry Sponsor
4 Previous Clinical Trials
504,389 Total Patients Enrolled
Canadian Institutes of Health Research (CIHR)OTHER_GOV
1,333 Previous Clinical Trials
25,722,347 Total Patients Enrolled
4 Trials studying Kidney Failure
5,488 Patients Enrolled for Kidney Failure

Media Library

Dialysate magnesium formulation of ≤1.0 mEq/L (≤0.5 mmol/L) (Electrolyte Replacement) Clinical Trial Eligibility Overview. Trial Name: NCT04079582 — N/A
Kidney Failure Research Study Groups: Higher dialysate magnesium, Lower dialysate magnesium
Kidney Failure Clinical Trial 2023: Dialysate magnesium formulation of ≤1.0 mEq/L (≤0.5 mmol/L) Highlights & Side Effects. Trial Name: NCT04079582 — N/A
Dialysate magnesium formulation of ≤1.0 mEq/L (≤0.5 mmol/L) (Electrolyte Replacement) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04079582 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any vacancies in this experiment for participants?

"According to clinicaltrials.gov, the initial posting of this trial was on April 4th 2022 and last amended October 21st 2022; however, it is not actively searching for patients at present. Nonetheless, 607 other trials are presently seeking enrolment from eager volunteers."

Answered by AI
~12500 spots leftby Mar 2026