Other

Imiquimod for Melanoma

Q: What medical ailments are most commonly treated with Pembrolizumab?

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Mayo Clinic in Florida, Jacksonville, FL

Targeting 4 different conditionsImiquimod +2 morePhase < 1Waitlist AvailableLed by Richard JosephResearch Sponsored by Mayo Clinic

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Platelet count >= 100,000/mm^3

Hemoglobin > 9.0 g/dL or >= 5.6 mmol/L without transfusion or (EPO) erythropoietin dependency (within 7 days of assessment)

Must not have

Be younger than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Upup to 2 years

Awards & highlights

All Individual Drugs Already Approved

Approved for 5 Other Conditions

No Placebo-Only Group

Study Summary

This trial studies the side effects and efficacy of imiquimod and pembrolizumab in treating patients with stage IIIB-IV melanoma.

Eligible Conditions

Metastatic Melanoma
Cutaneous Melanoma

Eligibility Criteria

Inclusion Criteria

You will be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 2 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 2 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Duration of response

Incidence of adverse events graded using Common Terminology Criteria for Adverse Events version 4.0

Overall survival

+2 more

Secondary outcome measures

Biomarker changes during treatment

Awards & Highlights

All Individual Drugs Already Approved

Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.

Approved for 5 Other Conditions

This treatment demonstrated efficacy for 5 other conditions.

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: Treatment (pembrolizumab, imiquimod)Experimental Treatment3 Interventions

Patients receive pembrolizumab IV on day 1 and apply imiquimod cutaneously on days 1-5 (Monday - Friday). Courses repeat every 21 days for up to 2 years (approximately 35 courses) in the absence of disease progression or unacceptable toxicity.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Imiquimod

FDA approved

Pembrolizumab

FDA approved

0 / 19Eligibility criteria met

Find a site

Who is running the clinical trial?

Mayo ClinicLead Sponsor

3,084 Previous Clinical Trials

3,491,844 Total Patients Enrolled

38 Trials studying Melanoma

2,031 Patients Enrolled for Melanoma

National Cancer Institute (NCI)NIH

13,412 Previous Clinical Trials

41,239,059 Total Patients Enrolled

554 Trials studying Melanoma

160,224 Patients Enrolled for Melanoma

Richard JosephPrincipal Investigator

Mayo Clinic

Media Library

Imiquimod (Other) Clinical Trial Eligibility Overview. Trial Name: NCT03276832 — Phase < 1

Melanoma Research Study Groups: Treatment (pembrolizumab, imiquimod)

Melanoma Clinical Trial 2023: Imiquimod Highlights & Side Effects. Trial Name: NCT03276832 — Phase < 1

Imiquimod (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03276832 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the scale of participation in this research project?

"As of now, this study is not currently enrolling. It was initially published in December 2017 and last edited on October 7th 2022; however, there are 832 studies recruiting participants with stage IV cutaneous melanoma AJCC V6 and V7 as well as 978 trials utilizing Pembrolizumab actively seeking volunteers."

Answered by AI

Are there any available openings for individuals seeking to join this clinical trial?

"This research project is not presently looking for new participants. It was first publicized on December 20th 2017 and most recently edited October 7th 2022. However, if you are searching for alternatives, 832 clinical trials with Stage IV cutaneous melanoma AJCC v6 & V7 are actively recruiting as well as 978 experiments using Pembrolizumab."

Answered by AI

What medical ailments are most commonly treated with Pembrolizumab?

"Pembrolizumab is typically utilized to treat non-operable melanoma, but it also has the potential to alleviate symptoms associated with microsatellite instability high and a heightened risk of recurrence."

Answered by AI

What other research has been conducted regarding the use of Pembrolizumab?

"At present, there are 978 clinical trials pertaining to Pembrolizumab in active progress and 127 of those studies have progressed past the second phase. Although numerous investigations are conducted out of Nashville, Tennessee, a total of 36006 research centres around the world are currently exploring this novel therapy."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Imiquimod and Pembrolizumab in Treating Patients With Stage IIIB-IV Melanoma

2017. "Imiquimod and Pembrolizumab in Treating Patients With Stage IIIB-IV Melanoma". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03276832.

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