MRI Study of Eating Behavior for Bulimia
What You Need to Know Before You Apply
What is the purpose of this trial?
An impaired ability to exert control has been implicated in bulimia nervosa (BN), but this impairment may not represent a stable trait or be the most effective focus for treatment. This project aims to understand how predictions and value-based decisions about control may be abnormally influenced by eating in individuals with BN, thereby maintaining cycles of binge eating, purging, and restriction.
Do I need to stop taking my current medications to join the trial?
The trial excludes participants with ongoing medical treatment that may interfere with the study, so you might need to stop certain medications. It's best to discuss your specific medications with the trial team.
Is MRI safe for studying eating behavior in bulimia?
How does this MRI-based treatment for bulimia differ from other treatments?
This MRI-based treatment for bulimia is unique because it focuses on understanding and potentially altering brain activity related to eating behaviors, using imaging techniques to explore neural pathways involved in hunger, satiety, and reward systems. Unlike traditional treatments that may focus on behavioral therapy or medication, this approach aims to identify and address the underlying brain mechanisms contributing to bulimia.24567
What data supports the effectiveness of the treatment Fasting state, Fed state, Magnetic Resonance Imaging, Lumakras, Vectibix for bulimia?
Research shows that brain imaging techniques like MRI can help understand the brain changes in bulimia, which might be useful in developing new treatments. However, there is no direct evidence supporting the effectiveness of Lumakras or Vectibix for bulimia, as these drugs are typically used for other conditions.12457
Who Is on the Research Team?
Laura A Berner, Ph.D.
Principal Investigator
Mount Sinai Icahn School of Medicine
Are You a Good Fit for This Trial?
This trial is for right-handed, English-speaking females aged 18-45 with a BMI between 18.5 and under 30 who meet the criteria for bulimia nervosa. It's not suitable for those medically unstable, on ongoing treatment, doing shift work, pregnant or lactating, allergic to meal ingredients used in the study, or unable to undergo an fMRI.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo fMRI scans after fasting and after a standardized meal to assess neural activation related to cognitive control in bulimia nervosa
Follow-up
Participants are monitored for changes in binge-eating, dietary restriction, and compensatory behaviors
What Are the Treatments Tested in This Trial?
Interventions
- Fasting state
- Fed state
- Magnetic Resonance Imaging
Find a Clinic Near You
Who Is Running the Clinical Trial?
Icahn School of Medicine at Mount Sinai
Lead Sponsor
National Institute of Mental Health (NIMH)
Collaborator