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MRI Study of Eating Behavior for Bulimia

N/A

Recruiting

Led By Laura A Berner, Ph.D.

Research Sponsored by Icahn School of Medicine at Mount Sinai

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline and 6-month follow-up

Awards & highlights

Study Summary

This trial wants to understand how bulimia nervosa affects people's decisions about control & eating, to develop better treatments.

Who is the study for?

This trial is for right-handed, English-speaking females aged 18-45 with a BMI between 18.5 and under 30 who meet the criteria for bulimia nervosa. It's not suitable for those medically unstable, on ongoing treatment, doing shift work, pregnant or lactating, allergic to meal ingredients used in the study, or unable to undergo an fMRI.Check my eligibility

What is being tested?

The study examines how eating affects decision-making and self-control in women with bulimia nervosa by comparing their brain activity before and after eating using MRI scans while they are in fasting and fed states.See study design

What are the potential side effects?

There may be minimal side effects related to fasting or consuming standardized meals. The MRI procedure might cause discomfort due to its enclosed nature but generally does not have significant side effects.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline and 6-month follow-up

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline and 6-month follow-up

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and 6-month follow-up for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Frontostriatal Activation Associated with Prediction Errors on the Stop Signal Task

Frontostriatal Activation Encoding the Subjective Value of Cognitive Effort on the Cognitive-Effort Discounting Task

Secondary outcome measures

Binge-eating Severity

Cognitive Effort Discounting Task Behavioral Performance

Compensatory Behavior Severity

+2 more

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Participants with Bulimia NervosaExperimental Treatment3 Interventions

Participants are randomly assigned (in even numbers across the two groups) to scan order: A. These participants are first scanned after 16 hours of fasting on one day, and are next scanned after a standardized meal on a second day. B. These participants are first scanned after a standardized meal on one day, and are next scanned after 16 hours of fasting on a second day.

Group II: Participants without Bulimia NervosaActive Control3 Interventions

Do I qualify?Apply below to find out

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Who is running the clinical trial?

Icahn School of Medicine at Mount SinaiLead Sponsor

861 Previous Clinical Trials

525,126 Total Patients Enrolled

4 Trials studying Bulimia

381 Patients Enrolled for Bulimia

National Institute of Mental Health (NIMH)NIH

2,786 Previous Clinical Trials

2,689,549 Total Patients Enrolled

34 Trials studying Bulimia

22,023 Patients Enrolled for Bulimia

Laura A Berner, Ph.D.Principal InvestigatorMount Sinai Icahn School of Medicine

1 Previous Clinical Trials

30 Total Patients Enrolled

1 Trials studying Bulimia

30 Patients Enrolled for Bulimia

Media Library

Participants with Bulimia Nervosa Clinical Trial Eligibility Overview. Trial Name: NCT05995496 — N/A

Bulimia Research Study Groups: Participants with Bulimia Nervosa, Participants without Bulimia Nervosa

Bulimia Clinical Trial 2023: Participants with Bulimia Nervosa Highlights & Side Effects. Trial Name: NCT05995496 — N/A

Participants with Bulimia Nervosa 2023 Treatment Timeline for Medical Study. Trial Name: NCT05995496 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What type of participants is this trial recruiting?

"The prerequisites for this trial are that applicants must have been diagnosed with bulimia and fall between the ages of 18 to 45. 169 participants in total will be recruited into the study."

Answered by AI

Is enrollment available for this investigation?

"This particular clinical trial, which was initially posted on August 1st 2023 and recently updated on the 15th of that month, is not currently accepting participants. However, per information hosted by clinicaltrials.gov there are presently 52 other studies in need of patient recruitment."

Answered by AI

Does this research encompass those aged 20 and over?

"This medical study is open to patients aged between 18 and 45 years old. For those under the age of 18, there are 15 additional clinical trials available and for those above 65, 27 more options exist."

Answered by AI

What are the main aims of this investigation?

"This clinical trial's primary objective is to evaluate Frontostriatal Activation Encoding of the Subjective Value of Cognitive Effort on the Cognitive-Effort Discounting Task over a 1-2.5 hours period following a standardised meal (fed state). Secondary endpoints include an assessment of Cognitive Effort Discounting Task Behavioural Performance, Binge eating Severity and Compensatory Behaviour Severity all based upon data collection from subjects via Eating disorder Examination and Ecological Momentary Assessment."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Changes in Inhibition and Valuation After Eating

Laura Berner 2023. "Changes in Inhibition and Valuation After Eating". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05995496.