Avocado Mango for Pre-diabetes

(AVMa Trial)

Overseen By Indika Edirisinghe, Ph.D

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Clinical Nutrition Research Center, Illinois Institute of Technology

Must not be taking: Lipid-lowering, Anti-inflammatory

Disqualifiers: Diabetes, Cardiovascular, Cancer, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 3

Duration: 8 weeks

80 Participants Needed

Trial Summary

What is the purpose of this trial?

This trial tests if eating one avocado and one mango daily can help people with prediabetes by improving their blood vessel health, cognitive function, and kidney function. Mangos have shown antidiabetic, anti-inflammatory, and heart-protective properties.

Do I need to stop my current medications to join the trial?

Yes, you may need to stop taking certain medications or supplements that could interfere with the study, such as lipid-lowering medications, anti-inflammatory drugs, and dietary supplements. If you choose to stop dietary supplements, a 30-day period without them is required.

What data supports the effectiveness of the treatment Avocado Mango for pre-diabetes?

Phenolic-rich plant extracts, similar to those found in avocados and mangoes, have been shown to improve blood sugar control in people with pre-diabetes. This suggests that Avocado Mango might help manage pre-diabetes by improving how the body handles sugar. ^{1 2 3 4 5}

How does the avocado mango treatment for pre-diabetes differ from other treatments?

The avocado mango treatment is unique because it utilizes the natural glucose-lowering properties of mango, which may help improve blood sugar control by inhibiting enzymes that break down carbohydrates and enhancing insulin sensitivity. Unlike standard medications, this treatment leverages the bioactive compounds in mango, offering a more natural approach to managing pre-diabetes. ^{6 7 8 9 10}

Research Team

Britt Burton-Freeman, Ph.D

Principal Investigator

Illinois Institute of Technology

Eligibility Criteria

This trial is for men and women aged 25-70 with prediabetes, having fasting blood glucose levels between 100-125 mg/dL. Participants should be in good health without major diseases or recent surgeries that could affect the study's results. They shouldn't take medications or supplements that might interfere with outcomes, must not abuse substances, and non-smokers are preferred.

Inclusion Criteria

I am between 25 and 70 years old.

I am in good health with no major organ diseases.

Able to abstain from alcohol consumption and avoid vigorous physical activity for 24 hours prior to and during study visit

Exclusion Criteria

I have not donated blood in the last 3 months.

I am not pregnant and do not plan to become pregnant during the study.

I have serious mental health or neurological conditions.

Timeline

Pre-Screening

Potential subjects complete a pre-screening questionnaire to determine eligibility

1-2 weeks

Online or phone interaction

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

1-2 visits (in-person)

Pre-Study Visit and Randomization

Participants undergo baseline cognitive assessment and are randomized into study groups

1 day

1 visit (in-person)

Treatment

Participants consume avocado and mango or control diet for 8 weeks with weekly visits for assessments and food pick-up

8 weeks

Weekly visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

2 months

1 visit (in-person)

Treatment Details

Interventions

• Avocado mango

Trial Overview The study tests how eating avocados and mangos affects vascular function over 8 weeks compared to a control diet. It measures changes in artery flexibility, blood pressure, eye vessel health using OCTA technology, cognitive performance through specific tasks, and kidney function indicators.

Participant Groups

Group I: Control meal plan Experimental Treatment 1 Intervention

2 meals and snacks per day, without avocado and mango, covering 75% of daily calories needs

Group II: Avocado mango meal plan Experimental Treatment 1 Intervention

2 meals and snacks per day, including 1 avocado + 1 cup of mango, covering 75% of daily calories needs,

Who Is Running the Clinical Trial?

Clinical Nutrition Research Center, Illinois Institute of Technology

Lead Sponsor

Trials

55

Recruited

3,000+

Hass Avocado Board

Collaborator

Trials

13

Recruited

760+

National Mango Board

Collaborator

Trials

7

Recruited

300+

Findings from Research

In a study involving patients with pre-diabetes, a nutraceutical compound containing Ilex paraguariensis, White Mulberry, and Chromium Picolinate significantly reduced fasting plasma glucose (FPG) by 7.8% and improved insulin resistance, with 67% of patients achieving normal insulin sensitivity after 3 months.

The treatment also led to a notable decrease in triglyceride levels by 8.3%, and 16.6% of patients returned to normal glycemic status, indicating the potential efficacy of this nutraceutical in managing pre-diabetes.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Ilex paraguariensis, white mulberry and chromium picolinate in patients with pre-diabetes. Derosa, G., D'Angelo, A., Maffioli, P.[2020]

A systematic review of 28 studies found that various parts of the mango plant, including leaves and flesh, exhibit glucose-lowering properties, suggesting potential benefits for managing type 2 diabetes in both animal models and humans.

The proposed mechanisms for mango's antidiabetic effects include inhibition of enzymes that break down carbohydrates, improved insulin sensitivity, and enhanced glucose uptake, although more research is needed to fully understand these mechanisms and their effectiveness in humans.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Antidiabetic properties of mango in animal models and humans: A systematic review. Zarasvand, SA., Mullins, AP., Arjmandi, B., et al.[2023]

In a study involving 34 healthy adults, fresh mango consumption led to greater feelings of fullness and reduced desire to eat compared to dried mango and white bread, indicating its potential benefits for satiety.

Fresh mango also resulted in more effective control of postprandial glucose levels, showing a significant decrease in blood sugar compared to dried mango and white bread, which could be particularly beneficial for individuals managing weight or type 2 diabetes.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Effects of fresh vs dried mango consumption on satiety and postprandial glucose in healthy adults. Stamper, C., Safadi, S., Gehr, A., et al.[2023]

In a study with 23 overweight and obese participants, consuming 100 kcal of fresh mangos resulted in a significantly lower insulin response compared to isocaloric low-fat cookies, indicating better metabolic control after eating mangos.

Mango consumption also led to greater feelings of fullness and reduced hunger compared to cookies, suggesting that mangos may be more effective in promoting satiety and managing food intake.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Fresh Mango Consumption Promotes Greater Satiety and Improves Postprandial Glucose and Insulin Responses in Healthy Overweight and Obese Adults. Pinneo, S., O'Mealy, C., Rosas, M., et al.[2022]

References

1. Switzerland pubmed.ncbi.nlm.nih.gov

A Narrative Review of Human Clinical Trials on the Impact of Phenolic-Rich Plant Extracts on Prediabetes and Its Subgroups. [2021]

2. England pubmed.ncbi.nlm.nih.gov

A higher-protein nut-based snack product suppresses glycaemia and decreases glycaemic response to co-ingested carbohydrate in an overweight prediabetic Asian Chinese cohort: the Tū Ora postprandial RCT. [2023]

3. England pubmed.ncbi.nlm.nih.gov

Ilex paraguariensis, white mulberry and chromium picolinate in patients with pre-diabetes. [2020]

4. Switzerland pubmed.ncbi.nlm.nih.gov

Effects of Dietary Red Raspberry Consumption on Pre-Diabetes and Type 2 Diabetes Mellitus Parameters. [2021]

5. England pubmed.ncbi.nlm.nih.gov

Effects of nut and seed consumption on markers of glucose metabolism in adults with prediabetes: a systematic review of randomised controlled trials. [2020]

6. United States pubmed.ncbi.nlm.nih.gov

Antidiabetic properties of mango in animal models and humans: A systematic review. [2023]

7. Ireland pubmed.ncbi.nlm.nih.gov

Postprandial glucose and insulin responses to various tropical fruits of equivalent carbohydrate content in non-insulin-dependent diabetes mellitus. [2022]

8. China pubmed.ncbi.nlm.nih.gov

Blood glucose responses of diabetes mellitus type II patients to some local fruits. [2019]

9. England pubmed.ncbi.nlm.nih.gov

Effects of fresh vs dried mango consumption on satiety and postprandial glucose in healthy adults. [2023]

10. United States pubmed.ncbi.nlm.nih.gov

Fresh Mango Consumption Promotes Greater Satiety and Improves Postprandial Glucose and Insulin Responses in Healthy Overweight and Obese Adults. [2022]