Avocado Mango for Pre-diabetes

(AVMa Trial)

Overseen By Indika Edirisinghe, Ph.D

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Clinical Nutrition Research Center, Illinois Institute of Technology

Must not be taking: Lipid-lowering, Anti-inflammatory

Disqualifiers: Diabetes, Cardiovascular, Cancer, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 3

Duration: 8 weeks

80 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores whether eating avocados and mangoes can improve blood vessel health and other body functions in people with prediabetes. Participants will follow a meal plan either with or without avocados and mangoes. The study will assess how these foods affect blood flow, blood pressure, and overall health, including brain and kidney function. It is suitable for non-smokers with slightly elevated blood sugar levels who are not on certain medications. As an unphased trial, this study provides a unique opportunity to contribute to understanding the potential health benefits of avocados and mangoes.

Do I need to stop my current medications to join the trial?

Yes, you may need to stop taking certain medications or supplements that could interfere with the study, such as lipid-lowering medications, anti-inflammatory drugs, and dietary supplements. If you choose to stop dietary supplements, a 30-day period without them is required.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research shows that eating avocados and mangoes is generally safe. Studies have found that these fruits can help control blood sugar and improve insulin use, suggesting they are well-tolerated by people with prediabetes.

In past studies, participants who ate mangoes daily for several weeks did not report major side effects and experienced improvements in blood sugar levels and insulin function. Similarly, avocados, consumed worldwide, are considered safe and provide healthy fats and other nutrients.

Overall, research supports that avocados and mangoes are safe to eat as part of a balanced diet. Participants in these studies did not report serious problems, making these fruits a promising option for improving health in people with prediabetes. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Researchers are excited about the avocado mango meal plan for pre-diabetes because it offers a natural, food-based approach to managing blood sugar levels. Unlike standard treatments that often involve medications like metformin or lifestyle changes centered on reducing sugar intake, this plan incorporates whole foods known for their health benefits. Avocados are rich in healthy fats and fiber, while mangoes provide essential vitamins and antioxidants, potentially improving insulin sensitivity and overall metabolic health. This makes the avocado mango meal plan a unique and appealing option for those looking to manage pre-diabetes with dietary changes.

What evidence suggests that avocado and mango consumption might be an effective treatment for prediabetes?

Research has shown that eating avocados and mangoes can help manage blood sugar levels. One study found that fresh mango controlled blood sugar better than dried mango. Another study discovered that eating mango daily for 24 weeks improved blood sugar control and lowered insulin resistance. In this trial, participants will follow either an Avocado Mango meal plan or a Control meal plan. These findings suggest that including avocado and mango in one's diet might help manage pre-diabetes by improving blood sugar levels and overall heart health. ^{1 2 3 6 7}

Who Is on the Research Team?

Britt Burton-Freeman, Ph.D

Principal Investigator

Illinois Institute of Technology

Are You a Good Fit for This Trial?

This trial is for men and women aged 25-70 with prediabetes, having fasting blood glucose levels between 100-125 mg/dL. Participants should be in good health without major diseases or recent surgeries that could affect the study's results. They shouldn't take medications or supplements that might interfere with outcomes, must not abuse substances, and non-smokers are preferred.

Inclusion Criteria

I am between 25 and 70 years old.

I am in good health with no major organ diseases.

Able to abstain from alcohol consumption and avoid vigorous physical activity for 24 hours prior to and during study visit

Exclusion Criteria

I have not donated blood in the last 3 months.

I am not pregnant and do not plan to become pregnant during the study.

I have serious mental health or neurological conditions.

Timeline for a Trial Participant

Pre-Screening

Potential subjects complete a pre-screening questionnaire to determine eligibility

1-2 weeks

Online or phone interaction

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

1-2 visits (in-person)

Pre-Study Visit and Randomization

Participants undergo baseline cognitive assessment and are randomized into study groups

1 day

1 visit (in-person)

Treatment

Participants consume avocado and mango or control diet for 8 weeks with weekly visits for assessments and food pick-up

8 weeks

Weekly visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

2 months

1 visit (in-person)

What Are the Treatments Tested in This Trial?

Interventions

• Avocado mango

Trial Overview The study tests how eating avocados and mangos affects vascular function over 8 weeks compared to a control diet. It measures changes in artery flexibility, blood pressure, eye vessel health using OCTA technology, cognitive performance through specific tasks, and kidney function indicators.

How Is the Trial Designed?

Group I: Control meal plan Experimental Treatment 1 Intervention

2 meals and snacks per day, without avocado and mango, covering 75% of daily calories needs

Group II: Avocado mango meal plan Experimental Treatment 1 Intervention

2 meals and snacks per day, including 1 avocado + 1 cup of mango, covering 75% of daily calories needs,

Who Is Running the Clinical Trial?

Clinical Nutrition Research Center, Illinois Institute of Technology

Lead Sponsor

Trials

55

Recruited

3,000+

Hass Avocado Board

Collaborator

Trials

13

Recruited

760+

National Mango Board

Collaborator

Trials

7

Recruited

300+

Published Research Related to This Trial

In a study involving patients with pre-diabetes, a nutraceutical compound containing Ilex paraguariensis, White Mulberry, and Chromium Picolinate significantly reduced fasting plasma glucose (FPG) by 7.8% and improved insulin resistance, with 67% of patients achieving normal insulin sensitivity after 3 months.

The treatment also led to a notable decrease in triglyceride levels by 8.3%, and 16.6% of patients returned to normal glycemic status, indicating the potential efficacy of this nutraceutical in managing pre-diabetes.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Ilex paraguariensis, white mulberry and chromium picolinate in patients with pre-diabetes. Derosa, G., D'Angelo, A., Maffioli, P.[2020]

In a study with 23 overweight and obese participants, consuming 100 kcal of fresh mangos resulted in a significantly lower insulin response compared to isocaloric low-fat cookies, indicating better metabolic control after eating mangos.

Mango consumption also led to greater feelings of fullness and reduced hunger compared to cookies, suggesting that mangos may be more effective in promoting satiety and managing food intake.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Fresh Mango Consumption Promotes Greater Satiety and Improves Postprandial Glucose and Insulin Responses in Healthy Overweight and Obese Adults. Pinneo, S., O'Mealy, C., Rosas, M., et al.[2022]

A systematic review of 28 studies found that various parts of the mango plant, including leaves and flesh, exhibit glucose-lowering properties, suggesting potential benefits for managing type 2 diabetes in both animal models and humans.

The proposed mechanisms for mango's antidiabetic effects include inhibition of enzymes that break down carbohydrates, improved insulin sensitivity, and enhanced glucose uptake, although more research is needed to fully understand these mechanisms and their effectiveness in humans.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Antidiabetic properties of mango in animal models and humans: A systematic review. Zarasvand, SA., Mullins, AP., Arjmandi, B., et al.[2023]

In a study involving 34 healthy adults, fresh mango consumption led to greater feelings of fullness and reduced desire to eat compared to dried mango and white bread, indicating its potential benefits for satiety.

Fresh mango also resulted in more effective control of postprandial glucose levels, showing a significant decrease in blood sugar compared to dried mango and white bread, which could be particularly beneficial for individuals managing weight or type 2 diabetes.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Effects of fresh vs dried mango consumption on satiety and postprandial glucose in healthy adults. Stamper, C., Safadi, S., Gehr, A., et al.[2023]

Citations

1. clinicaltrials.gov clinicaltrials.gov/study/NCT05353790

Dietary Exchanges With Avocado and Mango in Pre-diabetes The trial will test 2 dietary conditions which will be fresh fruit (1 avocado and 1 mango) compared to a control arm matched in calories (but not macronutrients ...

2. withpower.com withpower.com/trial/phase-vasodilation-9-2021-db793

Avocado Mango for Pre-diabetes (AVMa Trial) Fresh mango also resulted in more effective control of postprandial glucose levels, showing a significant decrease in blood sugar compared to dried mango and ...

3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC12428706/

Daily Mango Intake Improves Glycemic and Body ... In conclusion, daily consumption of mango for 24 weeks improved both short- and long-term blood glucose control, reduced insulin resistance, ...

4. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov/40941087/

Daily Mango Intake Improves Glycemic and Body ... Conclusions: The daily consumption of mango for 24 weeks improved the glycemic control, insulin sensitivity, and body composition in adults ...

5. clinicaltrials.gov clinicaltrials.gov/study/NCT05571800

Study Details | NCT05571800 | Effect of Mango ... The investigators hypothesize that daily consumption of one mango per day for 24 weeks will improve the indices of glycemic control, cardiovascular health, and ...

6. examine.com examine.com/research-feed/study/0eqZa0/?srsltid=AfmBOoo3ew1DpcDJ2Tjn_MrmfdPM_5LrrcIwZdCBLSuwXmrLnw5mfLq3

Mangoes may improve glycemic control - Study Summary Fasting blood glucose, the primary outcome, decreased with mango (−18.3 mg/dL) compared to the granola bar. Other outcomes, including HbA1c and ...

7. nutrition.gmu.edu nutrition.gmu.edu/news/2025-09/can-mango-day-keep-diabetes-away-pioneering-study-shows-benefits-foods-natural-sugars

Can a mango a day keep diabetes away - GMU Nutrition The group that consumed the daily mango showed improved blood glucose control, enhanced insulin sensitivity, and reduced body fat. Daily Mango ...