Meals + snacks: Avocado mango for Vasodilation

Phase-Based Progress Estimates
Clinical Nutrition Research Center, Chicago, IL
Vasodilation+7 More
Meals + snacks: Avocado mango - Other
All Sexes
What conditions do you have?

Study Summary

The research is designed as a randomized, 2-arm, parallel, controlled, human clinical trial to investigate the effects of avocado and mango consumption for 8 weeks on indices of macro- and micro- vascular function in individuals with prediabetes. FMD of the brachial artery, pulse wave velocity (PWV), central blood pressure (cBP), and Optical Coherence Tomography Angiography (OCTA) of the eye will be used for vascular assessments. The research plan will also explore cognitive and kidney function benefits of regular avocado and mango intake using specified cognitive tasks and kidney function biomarkers

Eligible Conditions

  • Vasodilation
  • Retinal Vascular
  • Impaired Glucose Tolerance
  • Vascular Stiffness
  • Cognitive Changes

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

12 Primary · 10 Secondary · Reporting Duration: baseline-8 weeks

baseline-8 weeks
Changes in Central Blood pressure
Changes in Cognitive Function
Changes in Cognitive Function-1
Changes in Cognitive Function-2
Changes in Cognitive Function-3
Changes in Cognitive Function-4
Changes in Cognitive Function-5
Changes in Cognitive Function-6
Changes in Foveal Avascular Zone area
Changes in Kidney function markers
Changes in Pulse Wave Velocity
Changes in Vascular Density superficial and deep
Changes in Vascular branch number
Changes in plasma biomarkers and measures of brain-derived neurotrophic factor: BDNF
Changes in plasma biomarkers and measures of brain-derived neurotrophic factor: IGF1
Changes in plasma biomarkers and measures of inflammation concentration: ICAM
Changes in plasma biomarkers and measures of inflammation concentration: IL-6
Changes in plasma biomarkers and measures of inflammation concentration: VCAM
Changes in plasma biomarkers: fasting insulin
Changes in plasma biomarkers:fasting glucose
Changes in plasma biomarkers:lipid profile
Changes in vascular function measured by Flow-mediated vasodilation of brachial artery

Trial Safety

Safety Progress

1 of 3

Trial Design

1 Treatment Group

Avocado mango meal plan
1 of 1
Experimental Treatment

80 Total Participants · 1 Treatment Group

Primary Treatment: Meals + snacks: Avocado mango · No Placebo Group · N/A

Avocado mango meal plan
Experimental Group · 1 Intervention: Meals + snacks: Avocado mango · Intervention Types: Other

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline-8 weeks
Closest Location: Clinical Nutrition Research Center · Chicago, IL
Photo of Chicago  1Photo of Chicago  2Photo of Chicago  3
2018First Recorded Clinical Trial
1 TrialsResearching Vasodilation
46 CompletedClinical Trials

Eligibility Criteria

Age 18+ · All Participants · 9 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You are judged to be in good health on the basis of the medical history.
You are able to abstain from alcohol consumption and avoid vigorous physical activity for 24 hours prior to and during study visit.
You are not taking any medications that would interfere with outcomes of the study.
You are able to comply and perform the procedures requested by the protocol.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.