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Coronary Calcium Screening + Statins for Cardiovascular Prevention (CorCal Trial)

N/A

Recruiting

Led By Joseph B Muhlestein, MD

Research Sponsored by Intermountain Health Care, Inc.

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

No known history, as documented in the EHR, of coronary artery disease, cerebrovascular disease, peripheral vascular disease, or diabetes mellitus at enrollment

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 5 years

Awards & highlights

CorCal Trial Summary

This trial will test whether a proactive cardiovascular prevention strategy, with or without coronary calcium screening, can prevent major adverse cardiac events better than current standard care.

Who is the study for?

This trial is for men aged 50-80 and women aged 60-80 with no history of cardiovascular disease or diabetes, who haven't used statins or had a coronary calcium test in the last 5 years. Participants must be able to provide electronic health records and understand study procedures.Check my eligibility

What is being tested?

The study tests if proactive heart disease prevention strategies, including coronary artery calcium screening followed by statin treatment, can prevent major cardiac events better than standard care in people at moderate risk but without current heart disease.See study design

What are the potential side effects?

Potential side effects may include those commonly associated with statins such as muscle pain, fatigue, digestive problems, and increased blood sugar levels which could lead to diabetes. The CT scan for calcium screening carries minimal risks like radiation exposure.

CorCal Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have no history of heart, brain blood vessel, peripheral artery diseases, or diabetes.

CorCal Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

MACE

CorCal Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Proactive CAC GroupExperimental Treatment1 Intervention

Investigational Interventional Group. Will undergo coronary artery calcium screening and will receive statin recommendation based on the cardiovascular risk algorithm.

Group II: Proactive Current National Guidelines GroupActive Control1 Intervention

Standard Interventional Control Group. Will receive treatment recommendation according to the current National guidelines for statin initiation and follow-up.

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Intermountain Health Care, Inc.Lead Sponsor

137 Previous Clinical Trials

1,954,110 Total Patients Enrolled

Joseph B Muhlestein, MDPrincipal InvestigatorIntermountain Medical Center

9 Previous Clinical Trials

32,779 Total Patients Enrolled

Media Library

Standard Treatment (Other) Clinical Trial Eligibility Overview. Trial Name: NCT03439267 — N/A

Cardiovascular Prevention Research Study Groups: Proactive CAC Group, Proactive Current National Guidelines Group

Cardiovascular Prevention Clinical Trial 2023: Standard Treatment Highlights & Side Effects. Trial Name: NCT03439267 — N/A

Standard Treatment (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03439267 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What conditions typically necessitate Coronary Artery Calcium Screening and Statin Treatment?

"Coronary Artery Calcium Screening and Statin Treatment is an effective method for treating kidney failure, as well as joint issues, osteodystrophy, and hypoparathyroidism."

Answered by AI

Are researchers currently enrolling participants into this experiment?

"Hosted on clinicaltrials.gov, this trial is presently enlisting participants and has undergone regular updates since its initiation in March 26th 2018. Its most recent edits were made 8/8/2022."

Answered by AI

What is the current enrollment figure for this trial?

"Affirmative. According to clinicaltrials.gov, this research project is actively recruiting patients since it was first uploaded on March 26th 2018 and most recently renewed on August 8th 2022. The goal of the study is to recruit 9000 individuals from one site only."

Answered by AI

Can individuals of legal age participate in this trial?

"The requirements for participation in this trial necessitate that applicants are aged 50 to 80. However, there are 19 investigations specifically targeted at those under 18 years old and 30 studies tailored towards individuals above 65 years of age."

Answered by AI

Are there any supplementary investigations concerning Coronary Artery Calcium Screening and Statin Treatment?

"Presently, there are 48 clinical trials exploring Coronary Artery Calcium Screening and Statin Treatment. Of these, 17 have reached Phase 3 status. Although the majority of said studies are based in Shanghai, 6453 locations across the world offer them."

Answered by AI

What type of people are suitable for participation in this medical experiment?

"To be considered suitable for this medical trial, patients must have cardiovascular primary prevention strategies in place and are restricted to those aged 50-80. The research team is looking to recruit a total of 9000 eligible candidates."

Answered by AI