Coronary Calcium Screening + Statins for Cardiovascular Prevention
(CorCal Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot have used statins before joining the study.
What data supports the effectiveness of the treatment Coronary Artery Calcium Screening + Statins for Cardiovascular Prevention?
Is coronary calcium screening with statins safe for humans?
Statins are generally well tolerated and have been studied in many trials with hundreds of thousands of people. However, they can have side effects, mainly affecting muscles, liver, kidneys, and the nervous system. Coronary calcium screening helps identify those who might benefit most from statins, especially if they have muscle complaints.24567
How does the statin treatment differ from other treatments for cardiovascular prevention?
What is the purpose of this trial?
The primary objective of this study is to test the effectiveness of a proactive cardiovascular primary prevention strategy, with or without the use of coronary calcium screening, compared to current standard care, in preventing future major adverse cardiac events (MACE), including all-cause death, non-fatal myocardial infarction (MI), stroke, or any arterial revascularization among a moderate risk population with no current evidence of cardiovascular disease.
Research Team
Joseph B Muhlestein, MD
Principal Investigator
Intermountain Medical Center
Eligibility Criteria
This trial is for men aged 50-80 and women aged 60-80 with no history of cardiovascular disease or diabetes, who haven't used statins or had a coronary calcium test in the last 5 years. Participants must be able to provide electronic health records and understand study procedures.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants are randomized to receive statin recommendations based on coronary calcium screening results or standard risk assessment results
Follow-up
Participants are monitored for major adverse cardiac events through electronic health records
Treatment Details
Interventions
- Coronary Artery Calcium Screening
- Standard Treatment
- Statin Treatment
Find a Clinic Near You
Who Is Running the Clinical Trial?
Intermountain Health Care, Inc.
Lead Sponsor