Fiber Food Introduction for Short Bowel Syndrome
(GREENBEANS Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you must be on a stable antibiotic regimen starting from 2 weeks before the study and throughout the study period.
What data supports the effectiveness of the treatment Green bean puree for Short Bowel Syndrome?
Is green bean puree safe for human consumption?
How does green bean puree treatment for short bowel syndrome differ from other treatments?
Green bean puree is unique for short bowel syndrome as it introduces dietary fiber in a pureed form, which may be easier to digest and absorb for patients with compromised intestines. Unlike other treatments that might focus on medication or supplements, this approach uses a natural food source to potentially improve gut health and nutrient absorption.1112131415
What is the purpose of this trial?
Short bowel syndrome (SBS) is a rare but challenging condition in which patients have insufficient bowel length to meet fluid, electrolyte, and nutrient requirements without parenteral support.The purpose of this study is to determine how well dietary fiber is tolerated in patients with or without short bowel syndrome based on assessment of gastrointestinal symptoms, weight, and corresponding changes in microbiome composition and metabolomics.
Research Team
Wenjing Zong, MD
Principal Investigator
University of Texas Southwestern Medical Center
Eligibility Criteria
This trial is for individuals with Short Bowel Syndrome (SBS) who are patients at UTSW outpatient clinics. They must have a history of SBS, confirmed by surgery or imaging, and their small bowel should be connected to some part of the colon without an ileocecal valve. Healthy controls without intestinal issues can also join if they consume minimal fiber and get most calories from non-fiber oral or tube feedings.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants are initiated on green bean purees added to enteral formula recipes, with increasing amounts over 3 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment, including microbiome and metabolome analysis
Treatment Details
Interventions
- Green bean puree
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Texas Southwestern Medical Center
Lead Sponsor
Children's Hospital of Philadelphia
Collaborator