Appendix Cancer Clinical Trials 2022

Browse 67 Appendix Cancer Medical Studies Across 117 Cities

2 Phase 3 Trial · 299 Appendix Cancer Clinics

Reviewed by Michael Gill, B. Sc.
Phase-Based Progress Estimates

Paclitaxelfor Ovary Cancer

Bethesda, MD
All Sexes
Background: Tumors that have spread to the lining of the abdomen from other cancers, such as cancer of the appendix, colon, or ovary, are called peritoneal carcinomatosis. In most cases, outcomes are poor. Researchers want to test a new treatment. Objective: To learn if the combination of oral nilotinib plus paclitaxel given by IV and directly into the abdomen can reduce tumors enough for people to have surgery. Eligibility: Adults aged 18 and older with peritoneal carcinomatosis that is too widespread for surgery. Design: Participants will be screened with: Physical exam Medical history Blood and urine tests Electrocardiogram Laparoscopy. They will get general anesthesia. Small cuts will be made in their abdomen. Tissue and fluid samples will be taken. Surveys about their health CT scans of their torso Participants will have up to 4 more laparoscopies. During the first procedure, a port will be placed under the skin of their abdomen (an IP port). It will be attached to a catheter that is placed in their abdomen. Participants will get treatment in 3-week cycles, for 3 or 6 cycles. They will take nilotinib by mouth twice daily. They will get paclitaxel by IP port (once per cycle) and by IV (twice per cycle). After cycles 3 and 6, they will have a laparoscopy and CT scans. Then they may take nilotinib and get IV paclitaxel for up to 1 year. At study visits, participants will repeat some screening tests. About 6 weeks after treatment ends and then every 3 months for 3 years, participants will have follow-up visits at NIH or with their local doctor.
Phase 2
25 Appendix Cancer Clinical Trials Near Me
New York, NY
Bethesda, MD
Tampa, FL
Orange, CA
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An interactive map to display trial locations for New York Presbyterian Hospital/Columbia University Irving Medical Center, National Institutes of Health Clinical Center, Moffitt Cancer Center, Chao Family Comprehensive Cancer Center, University of California, Irvine, and 96 more locations.
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Boston, Massachusetts
Dana Farber Cancer Institute
Saint Louis, Missouri
Washington University School of Medicine
Seattle, Washington
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Ludwig Institute for Cancer Research
University of Massachusetts, Worcester

About The Author

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 31st, 2021

Last Reviewed: August 16th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.