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Platelet Rich Plasma

PRP for Diminished Ovarian Reserve (PRP4AGE Trial)

N/A
Recruiting
Research Sponsored by Center for Human Reproduction
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 54 years and under
Age 54 years and under.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 months
Awards & highlights

PRP4AGE Trial Summary

This trial is testing whether a woman's ovaries will respond better to ovulation induction if given growth factors from Platelet Rich Plasma.

Who is the study for?
This trial is for women under 55 with diminished ovarian reserve, evidenced by a poor response to ovulation induction and specific hormone levels (FSH > 12, AMH < 1.1). Participants should not have taken Aspirin or Motrin for a week before treatment. Women with blood diseases, autoimmune conditions like lupus, or those on certain medications are excluded.Check my eligibility
What is being tested?
The study tests if injecting Platelet Rich Plasma (PRP) into the ovaries can stimulate follicle growth in women who've had inadequate responses to fertility treatments. Following PRP injections, routine fertility drugs will be used until hCG trigger.See study design
What are the potential side effects?
While the side effects of PRP are not detailed here, common ones may include pain at injection site, infection risk increase due to needle use, bleeding or bruising from the procedure.

PRP4AGE Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am 54 years old or younger.
Select...
I am 54 years old or younger.

PRP4AGE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Emergence of new ovarian follicles with evidence of estradiol production
Secondary outcome measures
Change in serum AMH
Number of participants that establish a Clinical Pregnancy
Number of participants with retrieval of oocytes in an IVF cycle

PRP4AGE Trial Design

1Treatment groups
Experimental Treatment
Group I: A-PRPExperimental Treatment1 Intervention
The cortex of each ovary will be injected with autologous platelet rich plasma.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
A-PRP
2018
N/A
~40

Find a Location

Who is running the clinical trial?

Center for Human ReproductionLead Sponsor
13 Previous Clinical Trials
1,101 Total Patients Enrolled
Norbert Gleicher, MDStudy ChairMedical Director
8 Previous Clinical Trials
759 Total Patients Enrolled

Media Library

Premature Ovarian Failure Research Study Groups: A-PRP
Premature Ovarian Failure Clinical Trial 2023: A-PRP Highlights & Side Effects. Trial Name: NCT04275700 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who else is applying?

What state do they live in?
Texas
California
New York
Other
How old are they?
18 - 65
What site did they apply to?
Center For Human Reproduction
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
0
1

Why did patients apply to this trial?

I want to have a baby and I believe that PRP could help. I’ve tried IVF, DHeA, Chinese meds, no luck. Hoping to try PRP to see if there could be any improvements.
PatientReceived 1 prior treatment
Hi I am actually not living in NY. I have a friend that lives there and I used her zip code. I live in Ireland but willing to travel to try this out.
PatientReceived no prior treatments
I’ve tried a few natural IVF cycles, with no success. Tried acupuncture and Chinese medicine and also seeing little to no improvement. Would like to try PRP.
PatientReceived 2+ prior treatments
After 4 rounds of ivf 4 protocols none of which I responded well to, Iv never made it to transfer and due to age my time is running out at this point I feel that my only hope of ever having a baby is to try something new in the hopes of a better outcome.
PatientReceived no prior treatments

What questions have other patients asked about this trial?

How long is the study? How long is the overall process,how many visits to the clinic do I need?
PatientReceived no prior treatments

How responsive is this trial?

Typically responds via
Phone Call
Email
Most responsive sites:
  1. Center For Human Reproduction: < 24 hours
Average response time
  • < 1 Day
Recent research and studies
clinicaltrials.govStudy
Study of PRP in Women With Evidence of Diminished Ovarian Reserve
2018. "Study of PRP in Women With Evidence of Diminished Ovarian Reserve". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04275700.
All > Premature Ovarian Failure
~1 spots leftby Jun 2024
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