This trial is evaluating whether Naproxen Sodium will improve 2 primary outcomes and 2 secondary outcomes in patients with Autoimmune Diseases. Measurement will happen over the course of Pre- to Post-8 week treatment.
This trial requires 70 total participants across 2 different treatment groups
This trial involves 2 different treatments. Naproxen Sodium is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 4 and have been shown to be safe and effective in humans.
"OCD runs as a familial disease in certain families. The data are consistent with the concept that shared genetic susceptibility leads to similar OCD-like phenotypes across families, while other environmental or nonshared factors underlie the presence of family-specific OCD phenotypes." - Anonymous Online Contributor
"The causes of both OCD and ADHD are poorly understood. Studies of comorbidity have found the prevalence of OCD and ADHD to be relatively high, suggesting that the two disorders may share risk factors." - Anonymous Online Contributor
"Symptoms of OCD include obsessions, and compulsions that may appear at any time of the day or for any reason. Those with OCD can get obsessions from all sorts of things, such as seeing, hearing, or recalling something which they are afraid is the opposite of what they are supposed to be doing at the time. People with OCD can feel compelled to act in a certain way, regardless of how they are feeling or what they think they should do. Even when their behavior is completely unrelated to whatever the thoughts they are feeling at that point, they can feel obligated to carry out the irrational behavior required to get the compulsion under control." - Anonymous Online Contributor
"According to ICD-9, OCD was diagnosed in 0.5 per 1,000 people in 2002. Assuming no overlap with psychiatric disorders in ICD-9, OCD is estimated to afflict 50,500 people in the United States with OCD in 2002. That fits neatly into the number of 50,000 reported in recent literature (see Cialdini et al., 2008). As OCD is an episodic disorder with a peak frequency within the first decade, the lifetime prevalence in the US is most likely to be at least 0.4%. As there were 677,000 people hospitalized for OCD in 2001, OCD should affect 1 in 2,200 of the population." - Anonymous Online Contributor
"Treatments for OCD are effective only in those with a'responder' pattern of symptom progression. Long-term treatment of OCD is probably not possible when only a small proportion of people improves. Furthermore, OCD is a very poor surrogate for 'well-being' and it is likely that'standard' psychotherapy is insufficient." - Anonymous Online Contributor
"Obsessive-compulsive disorder (OCD) is a mood disturbance characterized by obsessions (obsessions with a particular object or situation) and compulsions ( compulsion to perform certain actions repeatedly).\n" - Anonymous Online Contributor
"There is no single treatment that is effective for treating all types of OCD. There is considerable evidence that pharmacotherapy is a valid and effective treatment for OCD in both children and adults. The most often prescribed medications to treat OCD are SSRIs and anti-depressants. Another less common line of treatment for OCD concerns the use of neuroleptic medication such as chlorpromazine and clomipramine, or neurophysiologic treatments such as electroconvulsive therapy or transcranial magnetic stimulation. There are a variety of cognitive therapies that are also effective in the treatment of OCD." - Anonymous Online Contributor
"We found a high risk of extrapyramidal side effects in patients receiving naproxen, especially when combined with benzodiazepines. The authors hypothesize that naproxen causes extrapyramidal symptoms via a direct effect mediated by dopamine in the striatum, and not just by inhibition of cyclooxygenase as other NSAIDs do. Clinicians and patients should be cautious about combining naproxen and benzodiazepines." - Anonymous Online Contributor
"Based on the high and sustained discontinuation rate, naproxen sodium did not appear to provide adequate risk mitigation in the long term. Further study is needed to determine the efficacy and safety of naproxen as a safer alternative to analgesics such as paracetamol and NSAIDs for people with OA." - Anonymous Online Contributor
"The clinical use of naproxen sodium was not associated with increased co-medication use; the combination with non-medical drugs was not higher in patients receiving naproxen sodium than in other controls. The treatment response was similar; both groups had a small but statistically significant response. More studies are needed to confirm these results." - Anonymous Online Contributor
"There is a relatively large and growing body of empirical research on the etiology of OCD. Many theories of OCD are currently being investigated, and future research will likely employ innovative designs to further explore some theories." - Anonymous Online Contributor
"Cannabis use may play a leading role in some cases and is definitely part of the syndrome. For this condition, your doctor may suggest several treatments. The best way to overcome the symptoms of OCD is to seek psychotherapy through self-help or clinical services by qualified professionals.\n" - Anonymous Online Contributor