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Herbal Extract

Bonipar for Chronic Pain

Phase 2
Waitlist Available
Led By Lance Roy, MD
Research Sponsored by Winston Parris, MD
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline (approximately 24 hours before consent) to approximately 1 week post administration of study drug (or comparator)
Awards & highlights

Study Summary

This trial found that Bonipar is non-inferior to diclofenac topical solution 1.5% for efficacy and onset of action.

Eligible Conditions
  • Chronic Pain
  • Musculoskeletal Pain

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline (approximately 24 hours before consent) to approximately 1 week post administration of study drug (or comparator)
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline (approximately 24 hours before consent) to approximately 1 week post administration of study drug (or comparator) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Pain as Measured by Subjective Pain Intensity Rating (SPIR)
Secondary outcome measures
Number of Participants Who Experienced Adverse Effects and/or Complications
Other outcome measures
Time to the Onset of Action (the First Feeling of 20% Pain Reduction)

Side effects data

From 2022 Phase 2 trial • 164 Patients • NCT03471507
1%
Sneezing
1%
Tingling in left hand
1%
Mild tinnitus
1%
Dysgeusia
1%
Head Congestion
1%
Metallic taste
1%
Altered Gait
1%
Pruritus/itching
1%
Abdominal Muscle Spasm
1%
Dizziness and increased heart rate
1%
Headache
1%
Allergies
1%
Diarrhea with blood in the stool
1%
Lump formation on left thumb
1%
Rash on both sides of neck
1%
Nasal Congestion
1%
Rhinorrhea
1%
Dysesthesia/Numbness
1%
Change in blood pressure
1%
Radiating shoulder pain
1%
Rash
1%
Tingling toes in treated ankle
1%
Eye irritation
1%
Mild skin irritation
1%
Neck pain
1%
Dysesthesia
100%
80%
60%
40%
20%
0%
Study treatment Arm
Bonipar
Diclofenac Topical Solution 1.5%

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: BoniparExperimental Treatment1 Intervention
Group II: Diclofenac topical solution 1.5%Active Control1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Bonipar
2020
Completed Phase 2
~170

Find a Location

Who is running the clinical trial?

Winston Parris, MDLead Sponsor
Lance Roy, MDPrincipal InvestigatorDuke University

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who else is applying?

What state do they live in?
North Carolina
What site did they apply to?
Duke University Medical Center
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
3+
Recent research and studies
clinicaltrials.govStudy
Bonipar for Acute and Chronic Musculoskeletal Pain
Winston Parris, MD 2020. "Bonipar for Acute and Chronic Musculoskeletal Pain". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03471507.
~38 spots leftby Apr 2025
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