Probiotics for Prosthetic Joint Infection
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this study is to determine whether probiotics in addition to standard of care (SOC) can improve immunological markers following treatment for prosthetic joint infection (PJI). The study aims to determine whether probiotics in addition to SOC decrease immunological markers following treatment for PJI, improve medical and surgical complications and mortality in patients with PJI, and lead to improved gastrointestinal (GI)-specific patient reported outcomes measures (PROMs) in patients with PJI.
Will I have to stop taking my current medications?
The trial information does not specify if you need to stop taking your current medications. It mentions that there is an anticipated plan for eventual discontinuation of oral/IV antibiotics, but it doesn't provide details about other medications.
Are probiotics generally safe for human consumption?
Probiotics, like Lactobacilli and bifidobacteria, are generally considered safe for human consumption, with millions of people using them daily without increased risk. While rare cases of infections have been reported, studies show that probiotics are well-tolerated, even in immune-compromised individuals, and serious adverse events are not typically linked to their use.12345
How do probiotics differ from other treatments for prosthetic joint infection?
Probiotics are unique because they use beneficial bacteria to potentially help manage infections, unlike traditional treatments that rely on antibiotics and surgery. This approach may offer a novel way to support the body's natural defenses against infection without the side effects associated with long-term antibiotic use.678910
What data supports the effectiveness of the treatment Culturelle Digestive Daily Probiotic Capsule for prosthetic joint infection?
Research shows that probiotics can help reduce inflammation in conditions like rheumatoid arthritis, which is an inflammatory disease. This suggests that probiotics might also help manage inflammation in prosthetic joint infections, although direct evidence for this specific condition is not available.1112131415
Who Is on the Research Team?
Ran Schwarzkopf, MD
Principal Investigator
NYU Langone Health
Are You a Good Fit for This Trial?
This trial is for individuals with prosthetic joint infections in the hip or knee. Participants should have undergone standard treatment for these infections and are now looking at additional options to improve their immune response and overall outcomes.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive probiotics in addition to standard of care for 6 weeks during post-operative antibiotic treatment
Follow-up
Participants are monitored for safety, effectiveness, and quality of life outcomes after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Culturelle Digestive Daily Probiotic Capsule
Find a Clinic Near You
Who Is Running the Clinical Trial?
NYU Langone Health
Lead Sponsor