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Brachytherapy

3D Ultrasound-Guided Brachytherapy for Gynecologic Cancers

N/A

Recruiting

Research Sponsored by Western University, Canada

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patients with locally advanced or recurrent gynecological malignancies who are offered interstitial or ring and tandem brachytherapy treatment. These typically would include patients with primary or recurrent vaginal cancers, endometrial cancers or cervical cancers. Histologies of these cancers are typically adenocarcinomas or squamous cell carcinomas

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 16 months

Awards & highlights

Study Summary

This trial is testing whether 3D ultrasound can help guide needles during a cancer treatment called brachytherapy, to improve the accuracy of the treatment and spare healthy tissue.

Who is the study for?

This trial is for women aged 18 or older with advanced or recurrent gynecological cancers, such as vaginal, endometrial, or cervical cancers. It's specifically for those who are recommended to receive interstitial or ring and tandem brachytherapy treatments.Check my eligibility

What is being tested?

The study tests the use of real-time 3D ultrasound imaging during brachytherapy procedures in gynecologic cancer treatment. The goal is to improve needle placement accuracy and avoid damage to pelvic organs while ensuring the tumor receives an optimal dose.See study design

What are the potential side effects?

While not explicitly listed, side effects may include discomfort from the ultrasound procedure, potential risks associated with inaccurate needle placement if technology fails, and general risks related to brachytherapy like tissue irritation.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have advanced or recurrent cancer in my reproductive organs and am offered a specific radiation treatment.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 16 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~16 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 16 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Needle Localization Accuracy

Trial Design

1Treatment groups

Experimental Treatment

Group I: PatientsExperimental Treatment1 Intervention

Device: Gynecological brachytherapy requiring an Interstitial or ring and tandem insert involves insertion of the needle and applicators with no standard real-time image guidance. Occasionally 2-dimensional ultrasound is used, but it greatly limited by its flat nature, preventing a volumetric view of the needle pathways. Interstitial brachytherapy is done under general anesthesia. The trans-abdominal and trans-rectal standard 2D ultrasound that are used in some cases, will be expanded to 3D dimensional imaging through the use of an investigational device. Pre-procedure imaging in the form of MRI is used to help guide needles insertion as well as the clinical exam. Post-procedure CT is done for radiation planning.

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Western University, CanadaLead Sponsor

239 Previous Clinical Trials

57,418 Total Patients Enrolled

1 Trials studying Gynecologic Cancers

35 Patients Enrolled for Gynecologic Cancers

Media Library

Gynecological Brachytherapy (Brachytherapy) Clinical Trial Eligibility Overview. Trial Name: NCT04705467 — N/A

Gynecologic Cancers Research Study Groups: Patients

Gynecologic Cancers Clinical Trial 2023: Gynecological Brachytherapy Highlights & Side Effects. Trial Name: NCT04705467 — N/A

Gynecological Brachytherapy (Brachytherapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04705467 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are participants being enrolled in this clinical trial at this time?

"According to the latest information on clinicaltrials.gov, this particular trial is no longer recruiting patients. The listing was created on June 15th 2021 and edited as recently as April 26th 2021. Although this study has completed recruitment, there are many other opportunities available; currently, 75 other trials are actively looking for participants."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

3DUS Imaging of Needles in Gynecological Brachytherapy

2022. "3DUS Imaging of Needles in Gynecological Brachytherapy". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04705467.