Laser Treatment + CE Ferulic for Wrinkles

Overseen By West Dermatology Research Center

Age: 18+

Sex: Any

Trial Phase: Phase 2 & 3

Sponsor: Goldman, Butterwick, Fitzpatrick and Groff

Must not be taking: Isotretinoin, Topical steroids

Disqualifiers: Skin conditions, Infections, Autoimmune, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Prior Safety Data This treatment has passed at least one previous human trial

Compensation: Varies

Number of Visits: 6

Duration: 12 weeks

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores whether laser treatment combined with CE Ferulic, a skincare serum, reduces facial wrinkles more effectively than laser treatment with a different serum. It targets individuals with mild to moderate facial wrinkles who plan to undergo laser resurfacing. Participants should not have had recent facial procedures such as chemical peels or cosmetic surgeries. Those who have recently used specialized skincare products for wrinkles or skin tone may need to pause their use to participate. As a Phase 2 trial, this research measures the treatment's effectiveness in an initial, smaller group, allowing participants to contribute to early-stage treatment evaluation.

Will I have to stop taking my current medications?

The trial requires you to stop using certain skincare products and treatments four weeks before starting and during the study. However, it does not specify if you need to stop other medications, so it's best to discuss this with the study team.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research shows that CE Ferulic, a popular vitamin C serum, is generally safe and effective for most skin types. Studies have found it helps reduce wrinkles and brighten skin. However, individuals with very sensitive skin or allergies should apply a small amount first to test for reactions. Clinical settings have used CE Ferulic with laser treatment, and no major side effects have been reported. The treatment is currently in advanced clinical trials, indicating that earlier trials found it reasonably safe for people. ^{1 2 3 4 5}

Why are researchers excited about this trial's treatments?

Researchers are excited about the combination of laser treatment with CE Ferulic for wrinkles because it offers a two-pronged approach to skin rejuvenation. CE Ferulic, a potent blend of antioxidants, helps protect the skin from environmental damage and enhances its natural repair processes. When paired with the 1927nm non-ablative fractional diode laser, which stimulates collagen production and improves skin texture, this treatment aims to deliver more comprehensive results than standard topical creams or standalone laser treatments. This innovative pairing could potentially offer faster, more noticeable improvements in skin appearance with minimal downtime.

What evidence suggests that this trial's treatments could be effective for wrinkles?

This trial will compare the effects of using CE Ferulic with laser treatment versus a vehicle serum with laser treatment. Research has shown that CE Ferulic with laser treatment can significantly enhance skin appearance. It reduces wrinkles, firms the skin, and brightens the complexion. Specifically, studies have found that CE Ferulic can reduce wrinkles by 36%, increase skin glow by 44.8%, and improve skin elasticity by 36.6%. These findings suggest that CE Ferulic effectively refreshes sun-damaged skin. Combining this serum with laser treatment may enhance these benefits, offering a promising option for reducing signs of aging. ^{1 5 6 7 8}

Are You a Good Fit for This Trial?

Adults aged 30-70 with mild to moderate facial wrinkles, willing to undergo laser treatment and use birth control if applicable. Excludes those with certain skin conditions, allergies, or recent cosmetic procedures.

Inclusion Criteria

Fitzpatrick skin types I-VI

Physician evaluator classifying the subject as mild to moderate (Score 3-6) on the modified Griffiths 10-Point Scale for the face

Must be willing to give and sign an informed consent form and photographic release form

Exclusion Criteria

History of keloid or hypertrophic scarring

Any investigational treatment for improvement of skin quality and/or photodamage of facial skin during the 6-month period before the study treatment

Subjects who spray tanned or used sunless tanners in the treatment areas four (4) weeks prior to study treatment

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2 weeks

1 visit (in-person)

Pre-treatment

Participants use Skinceuticals CE Ferulic® or vehicle serum once daily for 2 weeks before laser treatment

2 weeks

1 visit (in-person)

Treatment

Participants receive two treatments with 1927nm non-ablative fractional diode laser paired with either Skinceuticals CE Ferulic® or vehicle serum

12 weeks

2 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

2 visits (in-person)

What Are the Treatments Tested in This Trial?

Interventions

• CE Ferulic

Trial Overview The trial tests the effectiveness of a laser treatment combined with CE Ferulic serum versus a sham comparator for improving signs of aging on the face.

How Is the Trial Designed?

Group I: Group A Active Control 2 Interventions

Subjects who will receive two treatments with 1927nm (Clear and Brilliant Perméa®) non-ablative fractional diode laser for rejuvenation of photodamaged skin of the face in pairing with Skinceuticals CE Ferulic

Group II: Group B Placebo Group 2 Interventions

Subjects who will receive two treatments with 1927nm (Clear and Brilliant Perméa®) non-ablative fractional diode laser for rejuvenation of photodamaged skin of the face in pairing with vehicle serum

Who Is Running the Clinical Trial?

Goldman, Butterwick, Fitzpatrick and Groff

Lead Sponsor

Trials

32

Recruited

660+

L'Oreal

Industry Sponsor

Trials

22

Recruited

11,100+

Citations

1. skinceuticals.com skinceuticals.com/skincare/vitamin-c-serums/c-e-ferulic-with-15-l-ascorbic-acid/S17.html

C E Ferulic® with 15% L-Ascorbic Acid C E Ferulic® clinical studies show a reduction in the appearance of wrinkles, improved skin firmness, and a brightened complexion. Wrinkles -36.0% ...

2. dermstore.com dermstore.com/p/skinceuticals-c-e-ferulic-with-15-l-ascorbic-acid-vitamin-c-serum-30ml/11289609/?srsltid=AfmBOooFQC5yNAhHs8cPshBaghYTb3z6l8z_x0y8NziUd6nYUKJ2Ze6k

SkinCeuticals C E Ferulic (1 fl. oz.) The product is widely praised for its ability to brighten skin, even out tone, reduce fine lines and wrinkles, and provide antioxidant protection.

3. lorealprofessionalskincare.com lorealprofessionalskincare.com/skinceuticals/science/clinical-studies

Clinical Studies | SkinCeuticals | LDB In this study, a randomized clinical study was conducted to evaluate the protective effects of a topically applied C E Ferulic antioxidant serum containing 15% ...

4. bluemercury.com bluemercury.com/products/skinceuticals-c-e-ferulic?srsltid=AfmBOooBaizEdBwsnsLTFfgRj3U-pjL58FBOb18TWcZKruIYtYLEah3I

C E Ferulic – SkinCeuticals Clinical Trials · 36%. saw a decrease in the appearance of wrinkles · 44.8%. saw an increase in the appearance of radiance · 36.6%. saw an increase in elasticity.

5. vogue.com vogue.com/article/skinceuticals-ce-ferulic-vitamin-c-review

SkinCeuticals CE Ferulic Review: Why It's Considered the ... “These ingredients in C E Ferulic work together to decrease the damage to the cells to slow down this aging process and decrease fine lines and ...

6. bluemercury.com bluemercury.com/products/skinceuticals-c-e-ferulic?srsltid=AfmBOopdkL7mJRvRGgjXXSAnEsMp2t415QpSGCZA1WgY0jPXyC3azKAG

C E Ferulic – SkinCeuticals #1 Dermatologist recommended vitamin C serum. Clinically proven to improve 8 signs of aging 8X. Stronger skin against environmental aggressors.

7. skinceuticals.com skinceuticals.com/ferulic-acid.html

Ferulic Acid Skincare Benefits Ferulic acid is generally safe for use for all skin types but those with very sensitive or allergy-prone skin, should patch-test any skincare with active ...

8. dermstore.com dermstore.com/p/skinceuticals-c-e-ferulic-with-15-l-ascorbic-acid-vitamin-c-serum-30ml/11289609/?srsltid=AfmBOor5YtVVXhXCeIh-0X_l4T4zEGGzbcg3n40rvXCGzxkkuItBWTyu

SkinCeuticals C E Ferulic (1 fl. oz.) The product is widely praised for its ability to brighten skin, even out tone, reduce fine lines and wrinkles, and provide antioxidant protection.