HPV Self-Sampling for Cervical Cancer
(HPVselftest Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a new method for women in Québec to self-screen for HPV (human papillomavirus), which can lead to cervical cancer. The goal is to determine if this self-sampling method is preferred and if it increases screening rates, particularly among women without a family doctor. Participants will be divided into four groups, each trying different methods to pick up and return their self-sampling kits. Women aged 25 to 65, who speak French and have internet access, may be suitable for this trial. The trial aims to make HPV screening easier and more accessible. As an unphased trial, this study offers a unique opportunity to contribute to more convenient and accessible cervical cancer screening for women in Québec.
Do I need to stop my current medications for this trial?
The trial information does not specify whether you need to stop taking your current medications. It seems focused on self-sampling for HPV, so it's unlikely that your medications would be affected, but you should confirm with the trial organizers.
What prior data suggests that HPV self-sampling is safe for cervical cancer screening?
Research has shown that HPV self-sampling is generally safe. One study found that samples collected by individuals for HPV testing are accurate and reliable, meaning the results can be trusted. Another study discovered that self-sampling for HPV is not only safe but also a good alternative to tests done in a clinic. Participants in various studies have found this method acceptable and easy to use.
Regarding side effects or negative outcomes, available data do not show any major safety concerns with self-sampling for HPV. Notably, self-sampling can make cervical cancer screening more accessible, especially for those who may not easily reach a doctor. Overall, evidence supports HPV self-sampling as a safe option for cervical cancer screening.12345Why are researchers excited about this trial?
Researchers are excited about this trial because it explores a new approach to cervical cancer screening through HPV self-sampling. Unlike traditional Pap smears that require a visit to a healthcare provider, this method allows women to collect their samples in a more comfortable and convenient setting, whether at home, a pharmacy, or a clinic. This flexibility could increase screening rates by making the process less intimidating and more accessible. By reducing barriers to testing, this self-sampling method has the potential to catch high-risk HPV infections earlier, ultimately improving early detection and outcomes for cervical cancer.
What evidence suggests that HPV self-sampling is an effective screening method for cervical cancer?
Research has shown that self-testing for HPV effectively screens for cervical cancer. In this trial, participants will be divided into groups based on how they receive and return their self-sampling kits. One group will receive and return their kit by mail, another will pick up their kit from a community pharmacy and return it by mail, a third group will collect their kit from a family planning clinic and perform the self-sample on-site, and a fourth group will retrieve their kit and perform the self-sample at a vaccination center. In one study, over 90% of women who received a positive result from self-testing sought the necessary medical care. This method can increase screening, especially for those who might not visit a clinic. Evidence confirms that self-testing is safe and accurate, providing a good alternative to traditional clinic tests. Overall, it has proven to be a reliable way to reach more people and enhance screening efforts.24678
Are You a Good Fit for This Trial?
This trial is for women aged 25-65 in Québec who are eligible for cervical cancer screening. It's designed to test if HPV self-sampling is an effective way to screen for cervical cancer, especially among those without a family doctor.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Self-sampling
Participants receive self-sampling kits and perform HPV self-sampling
Result Notification
Participants receive their HPV test results and next steps via email
Follow-up
Participants are monitored for safety and effectiveness after receiving results
What Are the Treatments Tested in This Trial?
Interventions
- HPV self-sampling test
Trial Overview
The study tests the feasibility of HPV self-sampling by dividing participants into four groups with different methods of kit distribution and return. The samples will be analyzed using the Cobas HPV test, and follow-up care pathways are planned based on results.
How Is the Trial Designed?
4
Treatment groups
Experimental Treatment
Finally, a fourth group will retrieve their kit and perform the self-sample at a vaccination center in Sherbrooke, with samples then transported by a local network.
One group will receive and return their self-sampling kit by mail.
A third group will collect their kit from a family planning clinic, perform the self-sample on-site, and it will be transported by a local courier network.
A second group will pick up their kit from a community pharmacy and return it by mail.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Université de Sherbrooke
Lead Sponsor
Citations
Self-sampling for HPV to enhance uptake of cervical ...
More than 90% of women with a positive HPV result in the self-sampling group complied with follow-up. As a result of this work, the Dutch screening program has ...
Clinical Validation of a Vaginal Cervical Cancer Screening ...
This study found that the SC device is a safe and accurate method for primary HPV cervical cancer screening, offering a preferred alternative to in-clinic ...
Impact of mode of offer of self-sampling to people overdue ...
The secondary outcome suggests those screened by self-sampling would not have been screened otherwise and contribute to increased screening ...
the promise and future of self-sampling HPV testing
Evidence from both high-income and low-income areas suggests that self-sampling HPV testing can effectively increase cervical cancer screening ...
Self‐collected vaginal specimens for human papillomavirus ...
One systematic review reported that, in 40 of 42 studies, self-collected primary HPV testing increased the proportion of participants completing ...
New Guidelines for HPV Testing Using Self Collection - NCI
New guidelines for clinicians performing cervical cancer screening advise on management of HPV test results from self-collected vaginal samples.
Self-Collection for Cervical Cancer Screening in a Safety- ...
Overall, 84 of 609 participants (13.8%) had a positive high-risk HPV test result that required follow-up (77 with cytology and 7 with colposcopy) ...
The acceptability, safety, and performance of primary cervical ...
Self-collection for HPV-based cervical screening during pregnancy is highly acceptable, safe, and feasible, with performance comparable to the general ...
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