← Back to Search

Analgesic

Ibuprofen + Acetaminophen vs Ibuprofen for Orofacial Pain

Q: Are there enrolment vacancies for this trial?

Affirmative, clinicaltrials.gov lists this study as actively searching for participants. It was published on December 10th 2019 and has been updated most recently on May 13th 2022. This trial is looking to recruit 375 patients from a single site.

Q: What ailment do Ibuprofen 200 mg and acetaminophen 650 mg typically address?

Ibuprofen 200 mg and acetaminophen 650 mg are two medicines that can be taken to mitigate the symptoms of catarrh, rhinorrhoea, and musculoskeletal <a href="https://www.withpower.com/clinical-trials/pain">pain</a>.

Q: What is the cap on individuals taking part in this research effort?

Affirmative, clinicaltrials.gov indicates that this experiment is presently recruiting patients. It first appeared on December 10th 2019 and was last updated May 13th 2022; 375 individuals across a single site are being sought out for enrollment.

Q: Have there been any past investigations related to the combination of Ibuprofen 200 mg and acetaminophen 650 mg?

As of now, the number of live trials involving Ibuprofen 200 mg and acetaminphen 650 mg stands at 109 with a third in Phase 3. Although numerous studies are being conducted out of Pittsburgh, <a href="https://www.withpower.com/clinical-trials/pennsylvania">Pennsylvania</a>, there is an expansive network encompassing 1033 sites running these experiments.

Q: Are there any specific restrictions as to who can participate in this research endeavor?

The criteria for eligibility includes age parameters between 12 and 80, as well as sufferance of facial <a href="https://www.withpower.com/clinical-trials/pain">pain</a>. This trial is aiming to recruit 375 participants in total.

Q: Are minors able to partake in this clinical research?

Those hoping to join this trial must be between the age of 12 and 80. If a person is younger or older than that, there are 39 studies available for minors and 87 options available for seniors.

Phase < 1

Recruiting

Research Sponsored by University of Colorado, Denver

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Currently not taking antibiotics or analgesics

Healthy with no significant medical findings

Timeline

Screening 3 weeks

Treatment Varies

Follow Up to be recorded at 0 hours, 6 hours, 12 hours, and 24 hours, 48 hours, 72 hours, and 96 hours after placement of appliances.

Awards & highlights

Study Summary

This trial will compare the effectiveness of ibuprofen and acetaminophen combined vs ibuprofen alone or placebo in controlling pain after orthodontic appliance placement.

Who is the study for?

This trial is for healthy individuals aged 12 and above who are about to start comprehensive orthodontic treatment, have not taken antibiotics or painkillers recently, and have no allergies to ibuprofen or acetaminophen. It excludes those under 12 or over 80, pregnant women, prisoners, people with decision-making impairments, kidney disease, liver issues, alcoholism, stomach ulcers or bleeding.Check my eligibility

What is being tested?

The study aims to determine if a combination of ibuprofen (200 mg) and acetaminophen (650 mg) is more effective in managing pain after orthodontic appliance placement than just ibuprofen alone or a placebo. Participants will be randomly assigned to one of these three treatments for four days.See study design

What are the potential side effects?

Possible side effects may include gastrointestinal issues like stomach upset or bleeding with ibuprofen use; liver damage from excessive acetaminophen intake; allergic reactions; fatigue; headache; dizziness.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am not currently taking any antibiotics or painkillers.

Select...

I am healthy with no major medical issues.

Select...

I am at least 12 years old.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ to be recorded at 0 hours, 6 hours, 12 hours, and 24 hours, 48 hours, 72 hours, and 96 hours after placement of appliances.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~to be recorded at 0 hours, 6 hours, 12 hours, and 24 hours, 48 hours, 72 hours, and 96 hours after placement of appliances.

This trial's timeline: 3 weeks for screening, Varies for treatment, and to be recorded at 0 hours, 6 hours, 12 hours, and 24 hours, 48 hours, 72 hours, and 96 hours after placement of appliances. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in visual analogue score (VAS) over time

Secondary outcome measures

Dosing Compliance

Trial Design

3Treatment groups

Experimental Treatment

Active Control

Placebo Group

Group I: Ibuprofen and acetaminophenExperimental Treatment1 Intervention

one 200 mg table of ibuprofen and two 325 mg tablets of acetaminophen

Group II: IbuprofenActive Control1 Intervention

one 200 mg tablet of ibuprofen and 2 placebo tablets

Group III: PlaceboPlacebo Group1 Intervention

3 tablets of tableting compounds with no active ingredients

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of Colorado, DenverLead Sponsor

1,738 Previous Clinical Trials

2,149,151 Total Patients Enrolled

Media Library

Acetaminophen (Analgesic) Clinical Trial Eligibility Overview. Trial Name: NCT04059172 — Phase < 1

Orofacial Pain Research Study Groups: Placebo, Ibuprofen, Ibuprofen and acetaminophen

Orofacial Pain Clinical Trial 2023: Acetaminophen Highlights & Side Effects. Trial Name: NCT04059172 — Phase < 1

Acetaminophen (Analgesic) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04059172 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there enrolment vacancies for this trial?

"Affirmative, clinicaltrials.gov lists this study as actively searching for participants. It was published on December 10th 2019 and has been updated most recently on May 13th 2022. This trial is looking to recruit 375 patients from a single site."

Answered by AI

What ailment do Ibuprofen 200 mg and acetaminophen 650 mg typically address?

"Ibuprofen 200 mg and acetaminophen 650 mg are two medicines that can be taken to mitigate the symptoms of catarrh, rhinorrhoea, and musculoskeletal pain."

Answered by AI

What is the cap on individuals taking part in this research effort?

"Affirmative, clinicaltrials.gov indicates that this experiment is presently recruiting patients. It first appeared on December 10th 2019 and was last updated May 13th 2022; 375 individuals across a single site are being sought out for enrollment."

Answered by AI

Have there been any past investigations related to the combination of Ibuprofen 200 mg and acetaminophen 650 mg?

"As of now, the number of live trials involving Ibuprofen 200 mg and acetaminphen 650 mg stands at 109 with a third in Phase 3. Although numerous studies are being conducted out of Pittsburgh, Pennsylvania, there is an expansive network encompassing 1033 sites running these experiments."

Answered by AI

Are there any specific restrictions as to who can participate in this research endeavor?

"The criteria for eligibility includes age parameters between 12 and 80, as well as sufferance of facial pain. This trial is aiming to recruit 375 participants in total."

Answered by AI

Are minors able to partake in this clinical research?

"Those hoping to join this trial must be between the age of 12 and 80. If a person is younger or older than that, there are 39 studies available for minors and 87 options available for seniors."

Answered by AI

Recent research and studies

Journal of Orofacial Orthopedics / Fortschritte der KieferorthopädieJournal

Relationship Between Patient Discomfort, Appliance Acceptance and Compliance in Orthodontic Therapy

Doll, Gerhard Michael, Andrej Zentner, Ulrich Klages, and Hans Georg Sergl. 2000. “Relationship Between Patient Discomfort, Appliance Acceptance and Compliance in Orthodontic Therapy”. Journal of Orofacial Orthopedics / Fortschritte Der Kieferorthopädie. Springer Science and Business Media LLC. doi:10.1007/pl00001908.

American Journal of Orthodontics and Dentofacial OrthopedicsJournal

Effects of Preoperative Ibuprofen on Pain After Separator Placement

Minor, Valerie, C. Kary Marris, Susan P. McGorray, Robert Yezierski, Roger Fillingim, Henrietta Logan, and Timothy T. Wheeler. 2009. “Effects of Preoperative Ibuprofen on Pain After Separator Placement”. American Journal of Orthodontics and Dentofacial Orthopedics. Elsevier BV. doi:10.1016/j.ajodo.2007.09.018.

Anesthesia & AnalgesiaJournal

Combining Paracetamol (acetaminophen) with Nonsteroidal Antiinflammatory Drugs

Ong, Cliff K. S., Robin A. Seymour, Phillip Lirk, and Alan F. Merry. 2010. “Combining Paracetamol (acetaminophen) with Nonsteroidal Antiinflammatory Drugs”. Anesthesia & Analgesia. Ovid Technologies (Wolters Kluwer Health). doi:10.1213/ane.0b013e3181cf9281.

formation/NLM/NIH, NCBI. “Gprobe”. 2017. Web. <https://github.com/ncbi/gprobe>..Journal