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Pain Management Techniques for ACL Surgery

N/A

Waitlist Available

Led By Cassandra Lee, MD

Research Sponsored by University of California, Davis

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Between the ages of 18 and 45 years old

Clinical and/or advanced imaging confirmation of ACL tear of which reconstructive surgery is recommended and accepted

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 24 weeks post-op

Awards & highlights

Study Summary

This trial will compare the efficacy of two pain interventions during ACL surgery.

Who is the study for?

This trial is for adults aged 18-45 who have confirmed ACL tears and are recommended to undergo reconstructive surgery. It's not suitable for those unable to consent, pregnant women, individuals with inflammatory arthritis, non-English speakers, anyone with prior knee surgeries, or prisoners.Check my eligibility

What is being tested?

The study compares standard pain management techniques during ACL reconstruction surgery. Specifically, it looks at the effectiveness of an adductor canal nerve block using Ropivacaine injection versus no nerve block in controlling pain and improving functional outcomes post-surgery.See study design

What are the potential side effects?

Potential side effects may include discomfort at the injection site, numbness in the leg due to the nerve block, possible allergic reactions to Ropivacaine including itching or rash, and less commonly complications related to nerve blocks such as infection.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am between 18 and 45 years old.

Select...

My ACL tear is confirmed by tests and I need surgery.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ immediately after surgery

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~immediately after surgery

This trial's timeline: 3 weeks for screening, Varies for treatment, and immediately after surgery for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Immediate Post-op Pain Score

Opioid Use

Secondary outcome measures

Intermediate-term Knee Function

Long-term Knee Function

Post-anaesthesia care unit (PACU) Time

+1 more

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Adductor Canal Nerve BlockExperimental Treatment2 Interventions

Participant will receive an adductor canal nerve block via 15 mL 0.5% ropivacaine injection prior to OR for ACL reconstruction. Participant will receive pre-op oral medications.

Group II: No Nerve BlockActive Control1 Intervention

Participant will receive pre-op oral medications but no nerve block prior to OR for ACL reconstruction.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Adductor Canal Nerve Block

2016

Completed Phase 4

~210

Ropivacaine injection

2012

Completed Phase 4

~510

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of California, DavisLead Sponsor

910 Previous Clinical Trials

4,706,931 Total Patients Enrolled

Cassandra Lee, MDPrincipal InvestigatorUC-Davis Health

Media Library

Adductor Canal Nerve Block Clinical Trial Eligibility Overview. Trial Name: NCT03365908 — N/A

Anterior Cruciate Ligament Rupture Research Study Groups: Adductor Canal Nerve Block, No Nerve Block

Anterior Cruciate Ligament Rupture Clinical Trial 2023: Adductor Canal Nerve Block Highlights & Side Effects. Trial Name: NCT03365908 — N/A

Adductor Canal Nerve Block 2023 Treatment Timeline for Medical Study. Trial Name: NCT03365908 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What requirements are necessary to participate in this clinical research?

"The current trial is searching for 60 participants, between the age of 18 and 45 years old with a ruptured condition. All applicants must also be within this specified age range to qualify."

Answered by AI

What is the primary goal of this clinical trial?

"This clinical experiment will be observed for a 6-week period post operation to gauge Immediate Post-op Pain Score. Secondary metrics of evaluation include Intermediate-term Knee Function, measured by Marx activity score (no units) which ranges from 0 - 16 and with zero indicating substantial limitation in mobility due to the knee; PACU Time signifying how long participants need pain management prior to release from the care unit, denoted in minutes; Long-term Knee Function, identified using Tegner activity score (no units), ranging from 0 - 10 where lower values denote incapability to engage in everyday activities due to their knees and ten representing"

Answered by AI

What symptoms is Adductor Canal Nerve Block commonly used to alleviate?

"Adductor Canal Nerve Block is a viable anesthetic option for patients undergoing anesthesia, surgery, or childbirth."

Answered by AI

What is the total number of individuals recruited for this experiment?

"As of now, this clinical trial is not currently enlisting participants. Initially posted on October 9th 2017 and last updated on January 26th 2022, one has to look elsewhere for studies accepting enrollees. Fortunately, 95 trials studying rupture are actively recruiting patients and 67 different Adductor Canal Nerve Block trials are also admitting new volunteers."

Answered by AI

What antecedent studies have examined the effects of Adductor Canal Nerve Block?

"As of now, 67 clinical trials are underway that research Adductor Canal Nerve Block. Of these tests, 15 have reached the third phase and most originate from Karachi, Sindh. 89 different locations are currently running studies on this procedure."

Answered by AI

Does this trial permit those aged thirty and over to participate?

"In agreement with the terms of this trial, any patient between 18 and 45 is eligible to take part."

Answered by AI

Are there any current openings for participants in this research?

"This experiment has concluded its recruitment phase. First posted on October 9th 2017 and last modified on January 26 2022, the trial is no longer admitting patients. However, if one desires to take part in a clinical study there are 95 studies actively enrolling for rupture and 67 trials recruiting participants for Adductor Canal Nerve Block."

Answered by AI

Recent research and studies

OrthopedicsJournal

Outpatient ACL Reconstruction Using Intraoperative Local Analgesia and Oral Postoperative Pain Medication

Aronowitz, Eric R, and Frederic A Kleinbart. 1998. “Outpatient ACL Reconstruction Using Intraoperative Local Analgesia and Oral Postoperative Pain Medication”. Orthopedics. SLACK, Inc.. doi:10.3928/0147-7447-19980701-07.

AnesthesiologyJournal

Adductor Canal Block Provides Noninferior Analgesia and Superior Quadriceps Strength Compared with Femoral Nerve Block in Anterior Cruciate Ligament Reconstruction

Abdallah, Faraj W., Daniel B. Whelan, Vincent W. Chan, Govindarajulu A. Prasad, Ryan V. Endersby, John Theodoropolous, Stephanie Oldfield, Justin Oh, and Richard Brull. 2016. “Adductor Canal Block Provides Noninferior Analgesia and Superior Quadriceps Strength Compared with Femoral Nerve Block in Anterior Cruciate Ligament Reconstruction”. Anesthesiology. Ovid Technologies (Wolters Kluwer Health). doi:10.1097/aln.0000000000001045.

versusJournal

Adductor Canal Block <i>versus</i> Femoral Nerve Block and Quadriceps Strength

Jæger, Pia, Zbigniew J.K. Nielsen, Maria H. Henningsen, Karen Lisa Hilsted, Ole Mathiesen, and Jørgen B. Dahl. 2013. “Adductor Canal Block versus Femoral Nerve Block and Quadriceps Strength”. Anesthesiology. Ovid Technologies (Wolters Kluwer Health). doi:10.1097/aln.0b013e318279fa0b.

AnesthesiologyJournal