Veliparib + Topotecan for Ovarian Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This phase I/II trial studies the side effects and best dose of veliparib and topotecan hydrochloride and to see how well they work in treating patients with solid tumors, ovarian cancer that has come back or does not respond to treatment, or primary peritoneal cancer. Veliparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as topotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving veliparib with chemotherapy may kill more tumor cells.
Will I have to stop taking my current medications?
The trial protocol does not specify if you need to stop taking your current medications. However, you cannot have had chemotherapy, immunotherapy, or certain other treatments within 4 to 6 weeks before joining the trial. It's best to discuss your specific medications with the trial team.
Is the combination of Veliparib and Topotecan safe for humans?
In a Phase I trial, the combination of Veliparib and Topotecan was found to have a manageable safety profile in patients with solid tumors. The main side effect was severe neutropenia (a drop in white blood cells) lasting more than 5 days, but overall, the treatment was considered safe enough to warrant further study.12345
What makes the drug Veliparib + Topotecan unique for ovarian cancer treatment?
The combination of Veliparib and Topotecan is unique because it combines a PARP inhibitor (Veliparib) with a topoisomerase I inhibitor (Topotecan), offering a novel mechanism of action compared to standard treatments like platinum-based therapies and taxanes. This combination may provide a new option for patients, especially those who have not responded to traditional therapies.678910
What data supports the effectiveness of the drug Veliparib + Topotecan for treating ovarian cancer?
Who Is on the Research Team?
Andrea E. Wahner Hendrickson, M.D.
Principal Investigator
Mayo Clinic Cancer Center LAO
Are You a Good Fit for This Trial?
This trial is for adults with certain advanced cancers, including ovarian cancer, fallopian tube cancer, or primary peritoneal cancer that have returned or are resistant to treatment. Participants must have measurable disease and should not have had more than two prior chemotherapy regimens. They need to be able to swallow medication and provide blood and urine samples as required by the study.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive veliparib orally on days 1-3, 8-10, and 15-17 and topotecan hydrochloride intravenously on days 2, 9, and 16. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
Follow-up
Participants are monitored for safety and effectiveness after treatment completion
What Are the Treatments Tested in This Trial?
Interventions
- Topotecan Hydrochloride
- Veliparib
Find a Clinic Near You
Who Is Running the Clinical Trial?
National Cancer Institute (NCI)
Lead Sponsor