Veliparib for Cancer
This study is evaluating whether veliparib and topotecan hydrochloride can be safely given together to treat patients with solid tumors, ovarian cancer that has come back or does not respond to treatment, or primary peritoneal cancer.
See full descriptionAbout the trial for Cancer
Treatment Groups
This trial involves 2 different treatments. Veliparib is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 1 & 2 and have already been tested with other people.
About The Treatment
Eligibility
This trial is for patients born any sex aged 18 and older. You must have received 1 prior treatment for Cancer or one of the other 6 conditions listed above. There are 10 eligibility criteria to participate in this trial as listed below.
Approximate Timelines
Measurement Requirements
This trial is evaluating whether Veliparib will improve 2 primary outcomes and 5 secondary outcomes in patients with Cancer. Measurement will happen over the course of 4 weeks.
Patient Q & A Section
How many people get cancer a year in the United States?
The cancer incidence in the United States is in approximate concordance with previously published estimates and can likely be accurately projected within a reasonable time frame for the U.S. and other Western nations.
What causes cancer?
Cancer is not solely a reflection of external causes, such as pollution, chemical exposure, and lifestyle choices. Many internal factors such as genetic susceptibility, as well as environmental factors in childhood are necessary for cancer to develop.
What is cancer?
In Canada, nearly 100,000 deaths from cancer occurred in 2009, making it the leading cause of death for people aged 15 and older and the 4th leading cause of death overall. More than half the cases were attributable to lung cancer.\n
What are common treatments for cancer?
Most treatments are used very commonly, even by the most unusual or unusual treatment users. However, some are not used by many users. The use of unconventional or unusual treatments may thus be associated with unique psychological and social needs.
What are the signs of cancer?
Even though a cancer has already originated, the signs and symptoms that are present are not necessarily obvious during a routine physical exam, even when the cancer is small.
Can cancer be cured?
The incidence and mortality of several cancers can be markedly reduced. Cancer can be prevented in many cases. There is no guarantee of curing cancer, but patients with metastatic and nonmetastatic cancers can live longer and healthier lives than those with no and only early stage cancers. Treatment options are limited but can provide meaningful improvements in many people.
What is the primary cause of cancer?
There is a need for a proper explanation of the primary causes of cancer that is understandable from a layman’s point of view. The disease, a malady which is found everywhere in the world and presents with a wide variety of symptoms, may manifest a different disease at different times in the life of specific individuals only. There are a multitude of possible causes with unknown triggers and interactions. Therefore it is important to understand the mechanism for cancer and its possible causes if the disease is to be cured in the future.
What is the latest research for cancer?
Cancer-related research is often focused on finding cures rather than understanding the causes. For example, recent publications often speculate on the possibility of a cure, but rarely focus on the more difficult problems like understanding how cancer can grow in the first place. There is an urgent need to identify molecular targets for cancer therapies in order to save lives and reduce the burden of cancer as a chronic disease.
What are the chances of developing cancer?
Cancer is an ever-increasing complication of the human body’s continual state of change - including the aging process, the accretion of extra-cellular body matter, and dietary factors. So what are the chances? It is difficult to predict the prevalence or emergence of a given cancer in an individual because the development of the actual cancer involves many unknown processes. What we can do, in fact, is estimate the odds, or to put it differently, what the best time to start developing a given cancer is. The most basic fact for a rational person is that the body always has a natural ‘defense mechanism’ against cancer: a continual natural regeneration on the cellular and physiological level.
Is veliparib typically used in combination with any other treatments?
The average duration of vELP in these 5 trials was 21 weeks. The average duration of vELP as monotherapy was 37 weeks and the average duration of vELP with additional chemotherapy and antiemetics was 39 weeks. This supports the current and expected combination use of (veliparib + chemotherapy/antiemetics) as an effective treatment for patients with gB-NS-C.
How does veliparib work?
Veliparib inhibits the expression of Pgp and ABCG2 for the purpose of targeting malignant cells to the cancerous/lesions. Thus, it can be said that these proteins function similarly and are therefore the most important regulators of malignant cells as well as a common target of therapeutic drugs.