Online Exercise Program for Osteoarthritis

(LIFT-OA Trial)

Overseen By Amelia Millward

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Intermountain Health Care, Inc.

Must be taking: OA medications

Disqualifiers: Neurological conditions, Dementia, Recent knee surgery, Severe osteoporosis, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 4

Duration: 6 months

334 Participants Needed

Trial Summary

Will I have to stop taking my current medications?

The trial protocol does not specify whether you need to stop taking your current medications. However, it does require documentation of medications specific to osteoarthritis and knee pain.

What data supports the effectiveness of the treatment Vivo Online Exercise Program for knee osteoarthritis?

Research shows that online exercise and education programs can improve function and well-being in people with knee osteoarthritis. Additionally, web-based exercise resources and educational programs promoting regular exercise have been found to enhance physical activity and functional capacity in these patients. ^{1 2 3 4 5}

Is the Vivo Online Exercise Program safe for humans?

The research articles reviewed focus on the benefits of exercise and education programs for knee osteoarthritis, but they do not provide specific safety data for the Vivo Online Exercise Program or similar programs. ^{1 3 4 5 6}

How is the Vivo Online Exercise Program treatment for knee osteoarthritis different from other treatments?

The Vivo Online Exercise Program is unique because it combines exercise with education and is delivered online, allowing patients to engage in therapeutic exercises and learn about their condition from home. This approach is different from traditional in-person exercise programs and offers flexibility and accessibility for patients with knee osteoarthritis. ^{1 3 4 7 8}

What is the purpose of this trial?

Potential participants will be screened at clinic. Patients who meet eligibility criteria will be considered for study. After written informed consent is obtained, participants will complete baseline testing and participants who meet eligibility criteria will be randomized 1:1 to 2 treatment arms: Vivo Arm: Vivo twice a week for 6 months and Usual Care Arm: meet with ATC and given Medbridge home exercise program for 6 months. All participants will be followed for 12 months, and will be assessed at 3-,6-, and 12-months. All participants will complete functional assessments, OA patient reported outcomes measures, quality of life, exercise self-efficacy, and fall risk questionnaires, and health care utilization report at each testing visit. A subset of Vivo participants will be asked satisfaction questions at the 3 and 6 month time points.

Research Team

Anthony Beutler, MD

Principal Investigator

Intermountain Health

Eligibility Criteria

This trial is for patients with osteoarthritis who have passed a screening at the clinic and consented to participate. Details on specific inclusion or exclusion criteria are not provided, but typically participants must meet certain health standards relevant to the study.

Inclusion Criteria

I am between 55 and 85 years old.

My knee arthritis is moderate to severe based on X-ray results.

I can walk and live at home.

Exclusion Criteria

I need help with at least one daily activity.

No concurrent enrollment in the Intermountain Arthrofit program

My osteoarthritis causes me no symptoms.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

1 visit (in-person)

Treatment

Participants are randomized to either the Vivo online exercise program or the Medbridge home exercise program for 6 months

6 months

Bi-weekly sessions (Vivo Arm), regular check-ins (Usual Care Arm)

Follow-up

Participants are monitored for safety and effectiveness after treatment, with assessments at 3, 6, and 12 months

12 months

3 visits (in-person) at 3, 6, and 12 months

Treatment Details

Interventions

• Vivo Online Exercise Program

Trial Overview The trial compares two exercise programs over six months: Vivo Online Exercise Program (twice weekly) versus Medbridge Home program (standard care). Participants will be randomly assigned to one of these groups and followed up for a year, with assessments every three, six, and twelve months.

Participant Groups

Group I: Vivo Online Exercise program Experimental Treatment 1 Intervention

Group II: Medbridge Home Exercise Program Active Control 1 Intervention

Who Is Running the Clinical Trial?

Intermountain Health Care, Inc.

Lead Sponsor

Trials

142

Recruited

1,965,000+

Impactiv, Inc.

Industry Sponsor

Trials

2

Recruited

420+

Findings from Research

Mind-body exercise programs, such as Hatha Yoga and Tai Chi, have been shown to effectively improve pain relief and physical function in patients with knee osteoarthritis, based on a systematic review of high-quality studies.

Hatha Yoga and Tai Chi Qigong received high grades for their effectiveness, with significant improvements noted in pain relief and quality of life, making them valuable non-traditional exercise options for managing knee osteoarthritis.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

The Ottawa panel clinical practice guidelines for the management of knee osteoarthritis. Part one: introduction, and mind-body exercise programs. Brosseau, L., Taki, J., Desjardins, B., et al.[2022]

A pilot study involving 65 individuals with mild to moderate knee osteoarthritis showed that using a web-based Therapeutic Exercise Resource Center (TERC) significantly improved clinical outcomes, including pain and function, after 8 weeks of exercise.

Participants reported high satisfaction with the TERC, with 94% finding the website easy to use and 90% appreciating the helpful exercise animations, indicating that this digital tool could enhance patient engagement in their treatment.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Web-based therapeutic exercise resource center as a treatment for knee osteoarthritis: a prospective cohort pilot study. Brooks, MA., Beaulieu, JE., Severson, HH., et al.[2022]

An 8-week online exercise and education program for knee osteoarthritis patients improved their sense of ownership over their treatment, leading to better function, well-being, and hope for the future.

While the online format provided beneficial peer support, participants expressed a need for more interactive engagement and suggested combining online sessions with in-person classes for enhanced support and individualized care.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

An invigorating journey towards better function and well-being: A qualitative study of knee osteoarthritis patients' experiences with an online exercise and education intervention. Simonÿ, C., Clausen, B., Beck, M., et al.[2023]

A systematic review of 26 high-quality studies found that various strengthening exercise programs significantly improve pain relief, physical function, and quality of life for patients with knee osteoarthritis within a six-month period.

Combining strengthening exercises with other therapeutic activities, like coordination and balance training, further enhances these benefits, indicating a comprehensive approach may be more effective for managing knee osteoarthritis.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

The Ottawa panel clinical practice guidelines for the management of knee osteoarthritis. Part two: strengthening exercise programs. Brosseau, L., Taki, J., Desjardins, B., et al.[2022]

An interdisciplinary educational program promoting regular physical exercise significantly improved functional capacity in individuals with knee osteoarthritis, with notable enhancements in stair performance, timed up and go tests, and sit-to-stand tests after 6 months, which were maintained after 12 months.

Participants in the educational program also experienced a significant reduction in body mass index and an increase in active individuals, while the control group showed no lasting improvements, highlighting the program's effectiveness in promoting physical activity and functional improvements.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Educational program promoting regular physical exercise improves functional capacity and daily living physical activity in subjects with knee osteoarthritis. Rodrigues da Silva, JM., de Rezende, MU., Spada, TC., et al.[2018]

A structured home-based exercise and patient education program significantly improved pain, functional mobility, and disability levels in 80 adults with knee osteoarthritis after eight weeks, compared to usual rehabilitation alone.

The experimental group showed greater improvements in all measured outcomes, with enhancements of 22.2% in disability, 44.1% in pain, and 15.7% in mobility compared to the control group, suggesting that this combined approach should be integrated into standard knee osteoarthritis management.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Effects of Self-management Program as Adjunctive to Usual Rehabilitation Exercise on Pain and Functional Outcomes in Knee Osteoarthritis: A Randomized Controlled Trial. Ahmad, MA., Yusof, A., Hamid, MSA., et al.[2023]

A systematic review of 11 randomized trials involving 1861 participants found that remote exercise programs can lead to clinically meaningful improvements in knee pain for individuals with osteoarthritis, although only one trial showed significant differences between groups.

The most effective interventions included personalized communication to tailor the exercise programs, highlighting the importance of engagement in remote management strategies for knee OA pain relief.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Effectiveness of remote exercise programs in reducing pain for patients with knee osteoarthritis: A systematic review of randomized trials. McHugh, CG., Kostic, AM., Katz, JN., et al.[2022]

Therapeutic exercises are effective for managing osteoarthritis (OA), improving muscle strength, joint stability, and reducing pain, with moderate effect sizes for aerobic (0.52) and strengthening exercises (0.32) in knee OA.

Individualized exercise programs are essential for OA patients, as there is no significant difference in efficacy between group and individual sessions, highlighting the need for collaboration among healthcare providers for optimal patient education and treatment.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Exercise Programmes for Osteoarthritis with Different Localization. Lambova, S.[2018]

References

1. England pubmed.ncbi.nlm.nih.gov

The Ottawa panel clinical practice guidelines for the management of knee osteoarthritis. Part one: introduction, and mind-body exercise programs. [2022]

2. England pubmed.ncbi.nlm.nih.gov

Web-based therapeutic exercise resource center as a treatment for knee osteoarthritis: a prospective cohort pilot study. [2022]

3. England pubmed.ncbi.nlm.nih.gov

An invigorating journey towards better function and well-being: A qualitative study of knee osteoarthritis patients' experiences with an online exercise and education intervention. [2023]

4. England pubmed.ncbi.nlm.nih.gov

The Ottawa panel clinical practice guidelines for the management of knee osteoarthritis. Part two: strengthening exercise programs. [2022]

5. England pubmed.ncbi.nlm.nih.gov

Educational program promoting regular physical exercise improves functional capacity and daily living physical activity in subjects with knee osteoarthritis. [2018]

6. Iran pubmed.ncbi.nlm.nih.gov

Effects of Self-management Program as Adjunctive to Usual Rehabilitation Exercise on Pain and Functional Outcomes in Knee Osteoarthritis: A Randomized Controlled Trial. [2023]

7. England pubmed.ncbi.nlm.nih.gov

Effectiveness of remote exercise programs in reducing pain for patients with knee osteoarthritis: A systematic review of randomized trials. [2022]

8. United Arab Emirates pubmed.ncbi.nlm.nih.gov

Exercise Programmes for Osteoarthritis with Different Localization. [2018]