Lidocaine vs Diphenhydramine for Skin Lacerations
Trial Summary
Will I have to stop taking my current medications?
The trial protocol does not specify whether you need to stop taking your current medications.
What data supports the effectiveness of the drugs lidocaine and diphenhydramine for treating skin lacerations?
Is it safe to use lidocaine or diphenhydramine for skin lacerations?
How does the drug diphenhydramine differ from lidocaine for treating skin lacerations?
What is the purpose of this trial?
Diphenhydramine, when injected locally, has been shown to achieve a certain level of local anesthesia. It has been documented for use in simple bedside procedures, however there is a gap in knowledge in its comparison to lidocaine. The purpose of the study is to determine if local infiltration of diphenhydramine is noninferior to the use of lidocaine 1% when trying to achieve local anesthesia for simple laceration repair. Patients who present to the emergency department with a simple laceration will be enrolled in the study. Patients will be evaluated for the pain of the injection as well as the pain of the laceration repair procedure post injection.
Eligibility Criteria
This trial is for individuals who come to the emergency department with simple lacerations that need only one layer of sutures and can be treated by emergency physicians. It's not suitable for those with complex wounds, active bleeding, allergies to lidocaine or diphenhydramine, or if their repair would benefit from epinephrine.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either lidocaine or diphenhydramine for local anesthesia during laceration repair
Follow-up
Participants are monitored for satisfaction and sensation reduction immediately after the procedure
Treatment Details
Interventions
- Diphenhydramine
- Lidocaine
Find a Clinic Near You
Who Is Running the Clinical Trial?
Florida Atlantic University
Lead Sponsor
Baptist Health South Florida
Collaborator