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Nonsteroidal Anti-inflammatory Drug

Meclofenamate for Brain Cancer

N/A
Waitlist Available
Led By Adrienne Boire, MD, PhD
Research Sponsored by Memorial Sloan Kettering Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
There is no limit on the number of brain metastases
Age 18-80
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 year
Awards & highlights

Study Summary

This trial is testing a drug to see if it can prevent brain metastasis growth. This is the first time the drug is being used to treat brain metastasis, and researchers want to see if it's effective and safe.

Who is the study for?
This trial is for adults aged 18-80 with recurrent or progressive brain metastasis from solid tumors, visible on MRI. Participants must have a stable systemic disease or no evidence of disease and can't be pregnant, have had recent surgery, active bleeding issues, severe allergies to NSAIDs like meclofenamate, certain heart conditions, uncontrolled systemic cancer growth, or poor kidney/liver function.Check my eligibility
What is being tested?
The study tests Meclofenamate's effectiveness in preventing new brain metastases in patients whose cancer has spread to the brain. It's a pilot study aimed at seeing if larger trials are feasible and understanding the drug's impact on both the patient and their brain metastasis.See study design
What are the potential side effects?
Potential side effects may include digestive system issues due to Meclofenamate’s properties similar to common pain relievers (NSAIDs). Since it was previously used for pain relief, risks might mirror those associated with NSAID use.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I may have multiple brain metastases.
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I am between 18 and 80 years old.
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I can care for myself but may need occasional help.
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I have at least one growing brain tumor from cancer that started elsewhere, visible on an MRI.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Feasible (if at least 50% of patients enrolled are evaluable in brain by MRI at the 2-month timepoint)
Secondary outcome measures
Adverse events
Progression free survival

Trial Design

1Treatment groups
Experimental Treatment
Group I: MeclofenamateExperimental Treatment1 Intervention
All enrolled patients will receive the study drug, meclofenamate at 100 mg PO BID.

Find a Location

Who is running the clinical trial?

Memorial Sloan Kettering Cancer CenterLead Sponsor
1,937 Previous Clinical Trials
588,290 Total Patients Enrolled
Adrienne Boire, MD, PhDPrincipal InvestigatorMemorial Sloan Kettering Cance Center

Media Library

Meclofenamate (Nonsteroidal Anti-inflammatory Drug) Clinical Trial Eligibility Overview. Trial Name: NCT02429570 — N/A
Brain Metastases Research Study Groups: Meclofenamate
Brain Metastases Clinical Trial 2023: Meclofenamate Highlights & Side Effects. Trial Name: NCT02429570 — N/A
Meclofenamate (Nonsteroidal Anti-inflammatory Drug) 2023 Treatment Timeline for Medical Study. Trial Name: NCT02429570 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Have there been any other investigations into the efficacy of Meclofenamate?

"Meclofenamate was first studied in 2015 at Memorial Sloan Kettering Cancer Center. As of today, there is one concluded trial and a single active investigation being carried out mainly from Middletown, Florida."

Answered by AI

How widely is this trial being conducted?

"This medical research is inviting patients to participate at 10 different sites, namely Memorial Sloan Kettering Monmouth in Middletown, Florida; Baptist Health South Miami in Pennsylvania; and Lehigh Valley Network in Allentown, New york."

Answered by AI

What medical conditions does Meclofenamate typically provide alleviation for?

"Meclofenamate is medically recommended for alleviating discomfort associated with osteoarthritis (OA) as well as mild pain, fever and hypermenorrhea."

Answered by AI

How many individuals may partake in this experiment?

"This clinical trial has concluded its recruitment of patients; it was originally posted on April 22nd 2015 and the most recent update took place May 4th 2022. If you are seeking other trials, 1901 studies for relapse-related topics presently require participants, while 1 study involving meclofenamate is still enrolling."

Answered by AI

Are participants being actively sought out for this research endeavor?

"Sign-ups for this clinical trial have now been concluded. The first posting was on April 22nd 2015 and the latest update occurred on May 4th 2022. Alternatively, there are 1901 studies seeking participants with relapse issues and a single trial recruiting volunteers to test meclofenamate."

Answered by AI

What are the requirements for participation in this clinical experiment?

"This clinical trial is willing to accept 30 patients that have experienced relapse, and are between 18 and 80 years old."

Answered by AI

Are any individuals aged 50 or older being considered for participation in the experiment?

"As detailed in the eligibility requirements, only applicants aged 18 and above but below 80 can participate in this trial."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Meclofenamate in Subjects With Recurrent or Progressive Brain Metastasis From Solid Tumor Primary
2015. "Meclofenamate in Subjects With Recurrent or Progressive Brain Metastasis From Solid Tumor Primary". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02429570.
All > Bone Metastases
~3 spots leftby Apr 2025
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