Aerobic exercise for Dementia

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Dementia+1 MoreAerobic exercise - Behavioral
Eligibility
50 - 80
All Sexes
What conditions do you have?
Select

Study Summary

This trial will test an exercise intervention for secondary prevention of ADRD in adults at increased risk for ADRD. The rationale for this trial is the urgent need for dementia prevention.

Eligible Conditions
  • Dementia
  • Alzheimer's Disease

Treatment Effectiveness

Study Objectives

1 Primary · 7 Secondary · Reporting Duration: Participants will be assessed at 6, 12 and 18 months.

Month 18
Change in Cognition Assessed by Neuropsychological Test Battery
Month 18
Change in Health behaviour with appropriate support strategies
Month 18
Change in Blood Biomarkers Assessed by Elisa Assays
Change in Brain Structure and Function Assessed by Neuroimaging Modalities
Change in Cerebral Blood Flow Assessed by Transcranial Doppler Ultrasound
Change in Maximal Oxygen Uptake (VO2max) Assessed by Metabolic Cart
Change in Risk/protective factors Assessed by Questionnaires
Change in Sleep Quality Assessed by Polysomnography, Actigraphy and Questionnaires

Trial Safety

Trial Design

1 Treatment Group

Aerobic exercise
1 of 1

Experimental Treatment

264 Total Participants · 1 Treatment Group

Primary Treatment: Aerobic exercise · No Placebo Group · N/A

Aerobic exercise
Behavioral
Experimental Group · 1 Intervention: Aerobic exercise · Intervention Types: Behavioral
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Aerobic exercise
2000
Completed Phase 2
~1080

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: participants will be assessed at 6, 12 and 18 months.

Who is running the clinical trial?

Canadian Institutes of Health Research (CIHR)OTHER_GOV
1,233 Previous Clinical Trials
24,676,388 Total Patients Enrolled
14 Trials studying Dementia
378,814 Patients Enrolled for Dementia
University of CalgaryLead Sponsor
706 Previous Clinical Trials
493,457 Total Patients Enrolled
5 Trials studying Dementia
1,073 Patients Enrolled for Dementia
Marc J Poulin, PhD, DPhilPrincipal InvestigatorUniversity of Calgary
3 Previous Clinical Trials
322 Total Patients Enrolled

Eligibility Criteria

Age 50 - 80 · All Participants · 10 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have one or more vascular risk factors for ADRD.
You are currently smoking.
You must provide a completed PAR-Q+ form (www.csep.ca), the standard method of obtaining physician approval for participation in an exercise program.
Subjects will be evaluated for subjective memory complaints using the MAC-Q Memory Complaint Questionnaire