Aerobic Exercise for Alzheimer's Disease
(BIMII Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests whether regular aerobic exercise can help prevent dementia in older adults with memory issues. The exercise program aims to improve brain health by boosting blood flow and fitness. Researchers hope to show that this can slow down or prevent cognitive decline.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is aerobic exercise safe for people with Alzheimer's disease?
How does aerobic exercise treatment differ from other treatments for Alzheimer's disease?
Aerobic exercise is unique because it may improve cognitive function and modify the underlying disease process in Alzheimer's patients, unlike many standard treatments that primarily focus on symptom management. It involves physical activity, such as cycling, which can enhance cardiorespiratory fitness and quality of life, offering a non-drug approach to managing the condition.13456
What data supports the effectiveness of the treatment Aerobic Exercise for Alzheimer's Disease?
Research suggests that aerobic exercise might help improve memory, thinking skills, and physical abilities in people with Alzheimer's disease. Some studies show that older adults with Alzheimer's can participate in aerobic exercise and experience improvements in dementia symptoms, although results can vary.12578
Who Is on the Research Team?
Marc J Poulin, PhD, DPhil
Principal Investigator
University of Calgary
Are You a Good Fit for This Trial?
This trial is for inactive adults aged 50-80 with memory complaints but no dementia, and at least one vascular risk factor like high blood pressure or diabetes. They should not be doing vigorous exercise more than twice a week and must speak English fluently. People with serious illnesses, history of stroke, or other conditions that could affect the study can't join.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo a 6-month aerobic exercise intervention, including supervised sessions 3 days/week with progressive intensity and duration.
Follow-up
Participants are monitored for changes in cognition, cerebral blood flow, and cerebrovascular reserve, with assessments at 12 and 18 months post-intervention.
What Are the Treatments Tested in This Trial?
Interventions
- Aerobic exercise
- Stretch and Strength
Aerobic exercise is already approved in United States, European Union, Canada for the following indications:
- Rehabilitation after stroke
- Improvement of physical function
- Enhancement of cognitive function
- Reduction of depression
- Cardiovascular rehabilitation
- Improvement of physical function
- Enhancement of cognitive function
- Rehabilitation after stroke
- Improvement of physical function
- Enhancement of cognitive function
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Calgary
Lead Sponsor
Canadian Institutes of Health Research (CIHR)
Collaborator