Endoscopic Resection Techniques for Esophageal Cancer
(BEEPER Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The study will compare EMR versus ESD technique (both combined with subsequent ablative therapy) of mucosal resection in Barrett's esophagus with regard to efficacy and risk in a long term setting.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but if you are on anticoagulants (blood thinners), you may need to stop them as they can make biopsies and resections impossible.
Is endoscopic resection safe for esophageal cancer?
How does the treatment of endoscopic resection techniques for esophageal cancer differ from other treatments?
Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are unique because they allow for the removal of early esophageal cancer without the need for traditional surgery, reducing recovery time and complications. ESD is particularly effective for deeper lesions, offering better complete removal rates, while EMR is quicker and easier to perform, making it a valuable option for early-stage cancers.23678
What data supports the effectiveness of the treatment Endoscopic mucosal resection (EMR) and Endoscopic submucosal dissection (ESD) for esophageal cancer?
Who Is on the Research Team?
Thomas Rösch, Prof. Dr.
Principal Investigator
Ph D, Director, Head of department
Are You a Good Fit for This Trial?
This trial is for patients with Barrett's esophagus needing mucosal resection and follow-up therapy, with lesions up to 10 cm. Participants must be able to comply with treatment and provide consent. It excludes those with serious illnesses, metastatic cancer, large or deep lesions, extensive Barrett's esophagus over 10 cm, or requiring more than two-thirds of the esophageal circumference resected.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD) followed by ablative therapy
Follow-up
Participants are monitored for safety and effectiveness after treatment, with follow-up endoscopies and histological assessments
What Are the Treatments Tested in This Trial?
Interventions
- Endoscopic mucosal resection
- Endoscopic submucosal dissection
Endoscopic mucosal resection is already approved in United States, European Union, Japan for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
Universitätsklinikum Hamburg-Eppendorf
Lead Sponsor