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Endoscopic Resection Techniques for Esophageal Cancer (BEEPER Trial)

N/A
Recruiting
Led By Thomas Rösch, Prof. Dr.
Research Sponsored by Universitätsklinikum Hamburg-Eppendorf
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patients to be treated for Barrett's esophagus by mucosal resection and following ablative therapy
Barrett's mucosal extension up to 10 cm maximum
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 51 months
Awards & highlights

BEEPER Trial Summary

This trial will compare two different ways of removing abnormal tissue from the esophagus, to see which is more effective and has fewer risks in the long term.

Who is the study for?
This trial is for patients with Barrett's esophagus needing mucosal resection and follow-up therapy, with lesions up to 10 cm. Participants must be able to comply with treatment and provide consent. It excludes those with serious illnesses, metastatic cancer, large or deep lesions, extensive Barrett's esophagus over 10 cm, or requiring more than two-thirds of the esophageal circumference resected.Check my eligibility
What is being tested?
The study compares two techniques for removing abnormal tissue in Barrett's esophagus: Endoscopic Mucosal Resection (EMR) and Endoscopic Submucosal Dissection (ESD), both followed by ablative therapy. The goal is to evaluate their long-term effectiveness and safety.See study design
What are the potential side effects?
Potential side effects from EMR and ESD may include bleeding, pain at the procedure site, risk of infection, tearing of the esophagus lining (perforation), and possible narrowing of the esophagus (stricture).

BEEPER Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am scheduled for treatment on my esophagus using resection and ablation.
Select...
My Barrett's esophagus extends no more than 10 cm.

BEEPER Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~51 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 51 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Eradication rate of neoplastic Barrett's Esophagus
Eradication rate of neoplastic Barrett's Esophagus, initial therapy success
Secondary outcome measures
Barrett Esophagus
Determination of differences in Barrett's esophagus subtypes: histologies
Determination of differences in Barrett's esophagus subtypes: patterns
+10 more

BEEPER Trial Design

2Treatment groups
Active Control
Group I: EMRActive Control1 Intervention
Endoscopic mucosal resection
Group II: ESDActive Control1 Intervention
Endoscopic submucosal dissection

Find a Location

Who is running the clinical trial?

Universitätsklinikum Hamburg-EppendorfLead Sponsor
466 Previous Clinical Trials
2,074,416 Total Patients Enrolled
Thomas Rösch, Prof. Dr.Principal InvestigatorPh D, Director, Head of department
9 Previous Clinical Trials
2,995 Total Patients Enrolled

Media Library

Endoscopic mucosal resection Clinical Trial Eligibility Overview. Trial Name: NCT03427346 — N/A
Esophageal Neoplasm Research Study Groups: EMR, ESD
Esophageal Neoplasm Clinical Trial 2023: Endoscopic mucosal resection Highlights & Side Effects. Trial Name: NCT03427346 — N/A
Endoscopic mucosal resection 2023 Treatment Timeline for Medical Study. Trial Name: NCT03427346 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are senior citizens being accepted as participants in this experiment?

"According to the study's eligibility requirements, participants must fall between 18 and 99 years old. There are also 7 trials geared towards minors and 306 for elderly patients."

Answered by AI

Are there any open spots for this trial at the present moment?

"This clinical trial is currently recruiting as reported on the aforementioned website. The study was first posted in December of 2016 with its most recent updates occurring in May of 2022."

Answered by AI

What is the upper limit for enrollment in this research endeavor?

"Affirmative. Clinicaltrial.gov displays information that this study is currently seeking participants, with the original posting date at December 1st 2016 and most recent update on May 30th 2022. This trial requires 407 individuals from a single location to participate."

Answered by AI

What ultimate goal is this clinical experiment hoping to achieve?

"This clinical trial will track the primary outcome of neoplastic Barrett's Esophagus eradication success following resection and ablation over a 33-month period. Secondary outcomes analysed include overall rate of curative eradication, endoscopic diagnostics for any kind of neoplasia, follow up surveillance after incomplete resections and recurrences, and differences in types of Barrett's esophagus observed during treatment."

Answered by AI

What are the criteria for participation in this clinical experiment?

"Participants who meet the criteria of being 18-99 years old, and having been diagnosed with barrett esophagus are encouraged to join this trial. As it stands, 407 individuals are needed for the study's completion."

Answered by AI
~65 spots leftby Oct 2025