Reflex Training for Spinal Cord Injury
Trial Summary
What is the purpose of this trial?
The purpose of this study is to validate the capacity of a reflex training system to change the size of the targeted reflex. For this, the researchers are recruiting 25 individuals with chronic incomplete SCI who have spasticity in the leg to participate in the reflex training procedure. The study involves approximately 45 visits with a total study duration of about 6 months.
Will I have to stop taking my current medications?
The trial does not require you to stop taking your current medications. However, your medications, including any for spasticity, should remain stable during the study. Changes in medication are unlikely but will be monitored and recorded.
What data supports the effectiveness of the treatment Spinal Reflex Operant Down Conditioning for spinal cord injury?
Research shows that operant conditioning of spinal reflexes can improve walking and balance in people with incomplete spinal cord injuries by targeting specific reflex pathways, leading to widespread beneficial changes in the nervous system. People have reported walking faster and farther, with less spasticity and better balance after undergoing this treatment.12345
Is reflex training for spinal cord injury safe for humans?
Studies in humans and animals suggest that operant conditioning of spinal reflexes is generally safe, with no significant safety concerns reported. This method has been used to improve motor function in people with spinal cord injuries, indicating its potential as a safe rehabilitation therapy.12367
How is the Reflex Training for Spinal Cord Injury treatment different from other treatments?
Research Team
Aiko Thompson, PhD
Principal Investigator
Medical University of South Carolina
Eligibility Criteria
This trial is for individuals with chronic incomplete spinal cord injury who can walk at least 10 meters, have leg spasticity, and are medically stable. They must be able to consent and not expect medication changes during the study. Excluded are those with unstable health, cognitive impairments, other neurological conditions, daily use of certain electrical stimulation devices, motoneuron injuries, serious heart issues, inability to test lower limb mobility or weight bearing, recent deep vein thrombosis or pregnancy.Inclusion Criteria
Exclusion Criteria
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
Baseline
Participants complete 6 baseline sessions to measure initial reflex activity
Conditioning
Participants undergo 30 conditioning sessions to down-condition the soleus H-reflex
Follow-up
Participants are monitored for changes in spasticity, muscle strength, and functional independence
Treatment Details
Interventions
- Spinal Reflex Operant Down Conditioning (Behavioral Intervention)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Medical University of South Carolina
Lead Sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborator