Emollient Skin Care for Eczema
(CASCADE Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether daily use of an emollient (a moisturizing lotion or cream) from birth can prevent eczema, a skin condition that may lead to other health issues like asthma and allergies. Participants can choose from popular over-the-counter emollients such as Vaseline or CeraVe. The trial invites parents who are the primary caretakers of infants aged 0 to 2 months, have internet access, and can communicate in English or Spanish. As an unphased trial, this study provides a unique opportunity to contribute to understanding preventative measures for eczema in infants.
Do I need to stop my baby's current medications for this trial?
The trial information does not specify whether you need to stop your baby's current medications. It seems focused on using emollients for skin care, so it's best to ask the trial coordinators for specific guidance.
What prior data suggests that these emollients are safe for newborns?
Research has shown that over-the-counter skin creams, like those used in this study, are generally easy for people to use without issues. Products such as Vaseline, CeraVe, and Cetaphil are designed to keep the skin moist and protected. For instance, Vaseline often soothes the skin and protects it from irritants or after minor injuries, and most people find it effective.
CeraVe products are specifically formulated to hydrate and calm skin prone to eczema, helping to relieve itching. However, some individuals might not prefer the greasy feel of ointments like Vaseline and CeraVe Healing.
Overall, these skin creams are widely used and recommended for treating dry skin conditions like eczema. They are considered safe and are part of international guidelines for managing atopic dermatitis.12345Why are researchers excited about this trial?
Researchers are excited about the emollient-based approach to eczema because it emphasizes daily, full-body application of lipid-rich moisturizers from infancy. Unlike traditional treatments that often rely on medicated creams and ointments only after eczema flares, this proactive method aims to prevent dryness and irritation before it starts. By allowing parents to choose from well-known over-the-counter options like Vaseline, CeraVe, and Cetaphil, this approach is tailored to individual preferences and needs, potentially enhancing adherence and effectiveness.
What evidence suggests that daily emollient use might be an effective treatment for preventing eczema?
This trial will compare the use of daily emollients with natural skin care practices. Studies have shown that using skin moisturizers daily can help prevent atopic dermatitis (AD), a common skin condition. Research indicates that regular application of moisturizers strengthens the skin's barrier, often weak in people with AD. One study found that products like Vaseline or CeraVe effectively and affordably reduce the risk of developing AD. These moisturizers are essential for treating and preventing AD because they keep the skin hydrated and protected. By maintaining a healthy skin barrier, the risk of AD and related allergies or skin issues can be reduced. Participants in this trial will have the option to choose from various emollients, including Vaseline, Vanicream, CeraVe Healing Ointment, CeraVe cream, and Cetaphil cream.56789
Who Is on the Research Team?
Eric Simpson
Principal Investigator
Oregon Health and Science University
Are You a Good Fit for This Trial?
This trial is for parents of infants aged 0-2 months who can communicate in English or Spanish, have internet access, and are patients at participating clinics. Infants with established eczema, adverse reactions to emollients, certain genetic syndromes, or extremely low birth weight cannot participate.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Daily full-body emollient application starting in the first 2 months of life to prevent atopic dermatitis
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Participant choice of over-the-counter emollients: Vaseline, Vanicream, CeraVe Healing Ointment, CeraVe cream, Cetaphil cream
Trial Overview
The study tests if daily use of over-the-counter emollients like Vaseline and CeraVe from birth prevents eczema development in newborns. It's a community-based trial aiming to set new care standards for all newborns.
How Is the Trial Designed?
Parent-infant dyads assigned to the intervention arm receive a lipid-rich emollient and educational materials promoting once daily full-body emollient use until the infant is 24 months old. Parents select one of five emollients to be mailed to the dyad's home at enrollment and approximately every six months for the duration of the study. These emollients include (1) CeraVe Healing Ointment, (2) Vaseline, (3) Cetaphil cream, (4) CeraVe cream, and (5) Vanicream.
Parent-infant dyads assigned to the control arm receive educational materials promoting general infant skin care guidelines only and are asked to refrain from emollient use unless dry skin develops (current standard of care guidelines).
Find a Clinic Near You
Who Is Running the Clinical Trial?
Oregon Health and Science University
Lead Sponsor
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Collaborator
University of Colorado, Denver
Collaborator
Duke University
Collaborator
University of Wisconsin, Madison
Collaborator
Citations
an atopic dermatitis primary prevention study using emollients ...
This study aims to measure the effectiveness of this intervention in a population not selected for risk via a pragmatic, randomized, physician-blinded trial.
Daily Moisturization for Atopic Dermatitis
Topical moisturizers are the core treatment for atopic dermatitis (AD), with treatment guidelines recommending at least daily thorough moisturization.
Cost-effectiveness of Prophylactic Moisturization for Atopic ...
The prophylactic use of moisturizers was determined to be cost-effective, with petroleum jelly demonstrating the best cost-benefit ratio ($353/QALY).
Efficacy of Nonprescription Moisturizers for Atopic Dermatitis
Clinical studies showed that moisturization (typically twice daily) significantly improved the skin barrier in adults and children with AD.
Treatment of Atopic Dermatitis
Ointments (eg, Aquaphor, Vaseline, CeraVe Healing) are very good moisturizers but because of their greasy feel may not be well tolerated by some ...
Environmental and behavioral mitigation strategies for ...
Consider avoiding products found to have dysbiotic potential including,: Aveeno Eczema Therapy, Curel Hydrotherapy, Eucerin Eczema Relief, Lubriderm ...
Petrolatum (Aquaphor, Cerave, Vaseline, and Others)
Petrolatum is applied to your skin or lips to help soothe and protect from irritants or after minor injuries. It is usually well tolerated.
Products for Eczema-Prone Skin
CeraVe's eczema creams and products for eczema-prone skin are formulated to help hydrate and soothe skin while providing temporary relief from itching.
Treatment of Atopic Dermatitis
Ointments (eg, Aquaphor, Vaseline, CeraVe Healing) are very good moisturizers but because of their greasy feel may not be well tolerated by some ...
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