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Emollient

Emollient Skin Care for Eczema (CASCADE Trial)

N/A
Waitlist Available
Led By Eric Simpson, MD
Research Sponsored by Oregon Health and Science University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Parent has a valid e-mail address or phone that can receive text messages.
Parent can speak, read, and write in English or Spanish.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 and 24 months
Awards & highlights

CASCADE Trial Summary

This trial will test whether emollient use from birth can prevent atopic dermatitis (a skin condition that often leads to asthma, food allergies, and other disorders) in a community setting.

Who is the study for?
This trial is for parents of infants aged 0-2 months who can communicate in English or Spanish, have internet access, and are patients at participating clinics. Infants with established eczema, adverse reactions to emollients, certain genetic syndromes, or extremely low birth weight cannot participate.Check my eligibility
What is being tested?
The study tests if daily use of over-the-counter emollients like Vaseline and CeraVe from birth prevents eczema development in newborns. It's a community-based trial aiming to set new care standards for all newborns.See study design
What are the potential side effects?
Potential side effects may include skin irritation or allergic reactions to the ingredients in the emollient products used such as Vaseline or CeraVe.

CASCADE Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have an email or a phone number that can receive texts.
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I can speak, read, and write in English or Spanish.
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I am a parent and I am 18 years old or older.
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I am the main caregiver for a newborn or infant up to 2 months old.

CASCADE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 and 24 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 and 24 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Cumulative incidence of provider-diagnosed AD
Secondary outcome measures
AD by Children's Eczema Questionnaire
AD by UK Working Party criteria
Asthma risk
+10 more
Other outcome measures
AD risk
Age at onset
Age of initiation
+11 more

CASCADE Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Daily EmollientExperimental Treatment1 Intervention
Parents assigned to the intervention arm will receive a lipid-rich emollient and educational materials promoting once daily full-body emollient use until their infant is 24 months old. Parents will select one of five emollients to be mailed to the dyad's home at enrollment and approximately every six months for the duration of the study. These emollients include (1) CeraVe Healing Ointment, (2) Vaseline, (3) Cetaphil cream, (4) CeraVe cream, and (5) Vanicream.
Group II: Natural SkinActive Control1 Intervention
Parents assigned to the control arm will receive educational materials promoting general infant skin care guidelines only and will be asked to refrain from emollient use unless dry skin develops (current standard of care guidelines).

Find a Location

Who is running the clinical trial?

University of Colorado, DenverOTHER
1,726 Previous Clinical Trials
2,140,426 Total Patients Enrolled
Duke UniversityOTHER
2,351 Previous Clinical Trials
3,408,203 Total Patients Enrolled
University of Wisconsin, MadisonOTHER
1,176 Previous Clinical Trials
3,010,756 Total Patients Enrolled

Media Library

Participant choice of over-the-counter emollients: Vaseline, Vanicream, CeraVe Healing Ointment, CeraVe cream, Cetaphil cream (Emollient) Clinical Trial Eligibility Overview. Trial Name: NCT03409367 — N/A
Atopic Dermatitis Research Study Groups: Daily Emollient, Natural Skin
Atopic Dermatitis Clinical Trial 2023: Participant choice of over-the-counter emollients: Vaseline, Vanicream, CeraVe Healing Ointment, CeraVe cream, Cetaphil cream Highlights & Side Effects. Trial Name: NCT03409367 — N/A
Participant choice of over-the-counter emollients: Vaseline, Vanicream, CeraVe Healing Ointment, CeraVe cream, Cetaphil cream (Emollient) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03409367 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are individuals aged 50 and above accepted in this trial?

"This research project is open to those aged 0 Days and under 63 Days."

Answered by AI

How many healthcare facilities have implemented this research trial?

"Patients can enroll in this clinical trial at Oregon Health & Science University, the University of Wisconsin-Madison, and the University of Colorado-Denver as well as four other sites."

Answered by AI

Is it still possible to join this experiment?

"Per clinicaltrials.gov, this medical research initiative is not presently enrolling individuals into the study; its initial posting was on July 3rd 2018 and it's last revision occurred April 29th 2021. Yet, 236 other trials are actively recruiting at present."

Answered by AI

Could I be admitted as a participant for this medical experiment?

"This particular medical trial is recruiting 1250 infants aged 0 to 63 days with eczema. To be considered, the primary caregiver must meet a few specifications: being 18 years or older at time of consent, having access to text and internet services, as well as being available for all study procedures throughout its duration."

Answered by AI
~187 spots leftby Mar 2025