Low Level Laser Therapy for Dyschezia

1
Effectiveness
1
Safety
McMaster University, Hamilton, Canada
Dyschezia+1 More
Low Level Laser Therapy - Device
Eligibility
Any Age
All Sexes
Eligible conditions
Dyschezia

Study Summary

This study is evaluating whether low level laser therapy will do more good than harm for patients with severe chronic refractory constipation.

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Eligible Conditions

  • Dyschezia
  • Constipation
  • Chronic Constipation

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Low Level Laser Therapy will improve 1 primary outcome and 5 secondary outcomes in patients with Dyschezia. Measurement will happen over the course of 4 weeks.

12 weeks
Change in number of bowel movements/week
Change in quality of life assessed by questionnaire PAC-QOL
Change in symptoms using the questionnaire PAC-SYM
4 weeks
Anal spincter pressure
Autonomic function assessment
Change in anal sphincter pressure due to attempting defecation

Trial Safety

Safety Estimate

1 of 3

Trial Design

2 Treatment Groups

Control
Refractory Constipation with LLLT

This trial requires 20 total participants across 2 different treatment groups

This trial involves 2 different treatments. Low Level Laser Therapy is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Refractory Constipation with LLLT
Device
Low level laser therapy (LLLT) will be administered to patients with severe refractory chronic constipation
ControlNo treatment in the control group
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Low Level Laser Therapy
2013
Completed Phase 1
~580

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 12 weeks
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 12 weeks for reporting.

Who is running the study

Principal Investigator
J. C.
Prof. Jihong Chen, Assistant Professor
McMaster University

Closest Location

McMaster University - Hamilton, Canada

Eligibility Criteria

This trial is for patients born any sex of any age. There are 2 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Patients with severe chronic refractory constipation
Must have undergone high resolution colonic manometry that shows abnormal coordination between colonic motility and ano-rectal function.

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can dyschezia be cured?

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The present findings do not provide evidence of a cure for dyschezia. Further, only a small number of patients will be left with persistent symptoms once the initial therapeutic step is complete.

Unverified Answer

What is dyschezia?

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Dyschezia is a condition where one experiences chronic and persistent constipation or other symptoms of dysuria, excessive passage of stool or faeces followed by a feeling of incomplete evacuation or abdominal distension which is accompanied by a desire to pass faecal matter. Many women have frequent and unremitting dyspnoea, diarrhoea and constipation. Women presenting with dyspnoea, diarrhoea and constipation have a high index of suspicion that dyschezia may be present and appropriate investigation is warranted.

Unverified Answer

What are the signs of dyschezia?

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Dyschezia is a condition that does not have a known cause. Recent findings, dyschezia was diagnosed in only 10% of the patients when examined in-person by a specialist. All patients presented chronic symptoms.

Unverified Answer

How many people get dyschezia a year in the United States?

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We estimate the prevalence of dyschezia is relatively high in the United States. Women and persons 20 years or older are twice as likely to be affected, compared with men. Older age increases the risk of dyschezia; people over 60 years of age are almost twelve times more likely to have dyschezia.

Unverified Answer

What are common treatments for dyschezia?

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While many conditions may present with dyspepsia-like symptoms, an exact etiology is not evident in many cases. Treatments include empiric antibiotic therapy for Helicobacter-related dysentry, or more specific treatment options such as empiric or adjunctive H2-receptor antagonists/proton pump inhibitors. Specific Helicobacter screening, proton pump inhibitors and cimetidine or tinidazole is also appropriate in some cases. The treatment of dysentery and celiac disease should be taken into account in some of the conditions causing dyspnea. Treatments must be tailored to the specific presentation of dyspnea.

Unverified Answer

What causes dyschezia?

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Dyschezia is a common and often unexplained condition with a variety of causes. The management of dyschezia may involve simple behavioural changes or, in refractory cases, the use of multiple therapies that can be grouped into 3 groups: medication, alternative therapies, and alternative medicine. While a small number of medical treatments are effective for a number of causes, many of these therapies appear to be only moderately effective and of unclear benefit.

Unverified Answer

How serious can dyschezia be?

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Dyschezia is not as serious as many might expect, but a serious problem that can cause discomfort for a person, particularly in social situations. Dyschezia may be treated with a standard-care medication such [metoclopramide] or an unconventional medicine, [loperamide]. Doctors and patients might consider seeking help from a certified dyschezia counselor.\n

Unverified Answer

Has low level laser therapy proven to be more effective than a placebo?

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Patients with symptomatic IBS-D experienced less symptom severity, and reported more overall improvement in symptoms, than those receiving a placebo treatment. The patients who took the low-level red laser radiation reported more improvements after 3 months compared to the placebo group. We can conclude that low-level red laser has significant therapeutic benefits in IBS-D.

Unverified Answer

What is the latest research for dyschezia?

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Dyschezia is a common problem for many people. If you have a doctor, ask him or her to diagnose and treat you. To help treat dyschezia that may not be painful, the National Institutes of Health recommends that women [who are not pregnant or breastfeeding; are over age 70; have an enlarged uterus or are [in the first or second trimester of pregnancy] eat foods high in [folic acid] and fiber, eat more fruit and vegetables each day, and limit intake of alcohol and caffeine.

Unverified Answer

What is the average age someone gets dyschezia?

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Overall dyschezia starts to develop at a rate of 11% at the age of 21 years. At this same age, 1% experience [severe symptoms] of chronic dyschezia. Furthermore, dyschezia can be caused by a number of factors, and it is unclear if dyschezia is a chronic condition. However, [if dyschezia is a chronic condition, then it is inevitable that symptomatic patients will develop dyschezia again as ages past 71 years old.

Unverified Answer

What is the primary cause of dyschezia?

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Primary dyschezia is a heterogenous group and is not a disease process of any particular organ but rather a symptom-based category. Primary dyschezia is not caused by dyspepsia, gastritis, reflux oesophagitis, IBS. As such, patient education regarding the causes of dyschezia is helpful, particularly given the limited options, often ineffective, for treatment.

Unverified Answer

How does low level laser therapy work?

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The present investigation was designed to define the efficacy of local LLLT for the management of dyssynergic defecation (DD) and constipation. We provide support that using local LLLT has the potential to be managed as a form of complementary therapy (rather than alternative therapy). However, due to the non-significant results of this study, the lack of consistency of these results in other studies, and the necessity of large studies for further definitive conclusions, the evidence presented does not justify the use of local LLLT for the treatment of DD.

Unverified Answer
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