← Back to Search

Antiarrhythmic

Minocycline + Amiodarone for Atrial Fibrillation (MINA Trial)

Phase 2
Waitlist Available
Led By Abdallah k Alameddine, MD
Research Sponsored by Baystate Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
All non-congenital cardiac operations are included: CABG, valve repair/replacement, or combination of CABG and heart valve operations
Patients who have undergone non-congenital cardiac operations including Coronary Artery Bypass Graft, valve repair/replacement, or combination of CABG and heart valve operations
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 30-days
Awards & highlights

MINA Trial Summary

This trial will test whether or not minocycline, a safe and common acne drug, is better at preventing atrial fibrillation than amiodarone, the current standard of care. If minocycline is found to be more effective, it could be incorporated into clinical care for this disease, improving outcomes and reducing costs.

Who is the study for?
This trial is for adults over 18 who've had non-congenital cardiac surgery and can use an iPhone to download ECGs. It's not for those with recent cancer, thyroid issues, current or past atrial fibrillation, severe lung disease, liver/kidney dysfunction, inflammatory diseases, on certain medications like immunosuppressants or steroids, pregnant women, or with a history of substance abuse.Check my eligibility
What is being tested?
The study tests if adding Minocycline to Amiodarone reduces the risk of developing atrial fibrillation after heart surgery more effectively than using Amiodarone alone. The goal is to improve patient outcomes and reduce healthcare costs associated with this common post-surgery complication.See study design
What are the potential side effects?
Amiodarone may cause various side effects including issues with the lungs, liver and thyroid; vision changes; skin discoloration; and digestive problems. Minocycline can lead to dizziness, light sensitivity, dental discoloration in children under eight years old (not applicable here), and gastrointestinal upset.

MINA Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have had heart surgery, including bypass or valve repair/replacement.
Select...
I have had heart surgery, such as bypass or valve repair.

MINA Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~30-days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 30-days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Post-op Atrial Fibrillation
Secondary outcome measures
30-day hospital death
Heart failure
Thromboembolism

MINA Trial Design

2Treatment groups
Experimental Treatment
Group I: minocyclineExperimental Treatment2 Interventions
intravenous minocycline 100 mg daily x 5 days starting intra-operatively combined with oral amiodarone (400 mg twice daily for 7 days, then 200 mg twice daily for the next 7 days
Group II: AmiodaroneExperimental Treatment1 Intervention
oral amiodarone
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Amiodarone
2010
Completed Phase 4
~5380
Minocycline
2005
Completed Phase 4
~1000

Find a Location

Who is running the clinical trial?

Baystate Medical CenterLead Sponsor
63 Previous Clinical Trials
44,213 Total Patients Enrolled
2 Trials studying Atrial Fibrillation
25,410 Patients Enrolled for Atrial Fibrillation
Abdallah k Alameddine, MDPrincipal InvestigatorBaystate Medical Center

Media Library

Amiodarone (Antiarrhythmic) Clinical Trial Eligibility Overview. Trial Name: NCT01422148 — Phase 2
Atrial Fibrillation Research Study Groups: Amiodarone, minocycline
Atrial Fibrillation Clinical Trial 2023: Amiodarone Highlights & Side Effects. Trial Name: NCT01422148 — Phase 2
Amiodarone (Antiarrhythmic) 2023 Treatment Timeline for Medical Study. Trial Name: NCT01422148 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What potential hazards come with using Amiodarone as a therapeutic treatment?

"Amiodarone has only been tested in Phase 2 trials, indicating that there is some evidence of safety but none for efficacy. For this reason, our team at Power assigned it a score of two on the scale from one to three."

Answered by AI

How many participants are taking part in this medical research?

"Unfortunately, this research study is not currently accepting applicants. Initially posted on February 1st 2023 and last updated on February 28th 2022, there are 475 studies actively recruiting patients with atrial fibrillation and 34 trials for Amiodarone searching for participants."

Answered by AI

Are there any vacancies left in this study for participants?

"Recruitment for this study has closed. It was initially announced on February 1st 2023 and underwent its last revision on the 28th of February 2022. If you are seeking to join clinical trials, there exist 475 studies currently enrolling patients suffering from atrial fibrillation as well as 34 medical research initiatives geared towards amiodarone-based treatments that need participants."

Answered by AI

Could you elucidate the research conducted into Amiodarone's therapeutic applications?

"Presently, there are 34 Amiodarone-based clinical trials in operation with the highest number of studies located in Perth, Western Australia. Of these studies, 10 have reached Phase 3 and a total of 75 sites worldwide offer this intervention."

Answered by AI

To what ailments is Amiodarone typically recommended?

"Amiodarone is generally prescribed to treat typhus fever and can additionally be used for treating disease, relapsing fever, and trachoma."

Answered by AI

Who else is applying?

What state do they live in?
Alabama
What site did they apply to?
Abdallah Alameddine
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
3+
Recent research and studies
clinicaltrials.govStudy
Minocycline Plus Amiodarone Versus Amiodarone Alone for the Prevention of Atrial Fibrillation After Cardiac Surgery
Abdallah Alameddine 2024. "Minocycline Plus Amiodarone Versus Amiodarone Alone for the Prevention of Atrial Fibrillation After Cardiac Surgery". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01422148.
All > Afib > Atrial Fibrillation
~40 spots leftby Jan 2027
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top