Timing of Resistance Exercise for Insulin Sensitivity
Trial Summary
What is the purpose of this trial?
The primary aim of this study is to evaluate if a single bout of AM vs PM resistance exercise has different effects on insulin sensitivity and sleep. A randomized cross-over trial be used to compare resistance exercise at two different times of the day. Each condition will take place in a laboratory setting. Each condition will consist of exercise, overnight sleep, and oral glucose tolerance tests the following day. The AM exercise will occur \~1.5 hours after habitual wake, and PM exercise will occur \~11 hours after habitual wake. After a 2-6 week washout, participants will complete the other condition. The hypothesis is that PM exercise will be more beneficial than AM exercise in improving insulin sensitivity. This study could identify if there is a better time of day to perform resistance exercise to decrease risk of developing Type 2 Diabetes Mellitus.
Do I have to stop taking my current medications for the trial?
The trial does not specify if you need to stop taking your current medications. However, if you are on weight loss medication or medications that affect energy balance, you may not be eligible to participate.
What data supports the effectiveness of the treatment Resistance Exercise Timing for improving insulin sensitivity?
Research shows that resistance exercise can improve insulin sensitivity, especially when performed at high intensity and with multiple sets. This suggests that the timing of resistance exercise could be important for enhancing insulin sensitivity, as different exercise protocols have shown varying levels of effectiveness.12345
Is resistance exercise timing safe for humans?
How does the timing of resistance exercise improve insulin sensitivity compared to other treatments?
The timing of resistance exercise is unique because it focuses on when the exercise is performed to enhance insulin sensitivity, unlike other treatments that may not consider timing as a factor. This approach can lead to improved blood sugar control by optimizing the body's response to insulin after exercise.2791011
Eligibility Criteria
This trial is for men and women aged 50-74 with a BMI of at least 25 but less than 45, who are generally healthy but not very active. They shouldn't have major health issues like uncontrolled heart or lung diseases, recent cancer treatment, untreated thyroid problems, or a history of eating disorders or weight loss surgery.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
AM Resistance Exercise
Participants perform resistance exercise in the morning, approximately 1.5 hours after habitual wake time, followed by overnight sleep and oral glucose tolerance tests the next day
Washout
A washout period between the AM and PM exercise conditions
PM Resistance Exercise
Participants perform resistance exercise in the evening, approximately 11 hours after habitual wake time, followed by overnight sleep and oral glucose tolerance tests the next day
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Resistance Exercise Timing
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Utah
Lead Sponsor