Timing of Resistance Exercise for Insulin Sensitivity
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether resistance exercise in the morning or evening better improves insulin sensitivity and sleep. Insulin sensitivity measures how well the body uses sugar, which is crucial for preventing Type 2 Diabetes. Participants will perform exercises in a lab either in the morning or evening, then switch to the other time after a break. This trial suits adults aged 50 to 74 who are generally healthy, not currently meeting exercise guidelines, and have a BMI (a measure of body fat based on height and weight) between 25 and 45. As an unphased trial, it offers a unique opportunity to contribute to understanding the optimal timing of exercise for health benefits.
Do I have to stop taking my current medications for the trial?
The trial does not specify if you need to stop taking your current medications. However, if you are on weight loss medication or medications that affect energy balance, you may not be eligible to participate.
What prior data suggests that this exercise timing is safe for participants?
Research shows that exercising with weights in the morning or evening is generally safe and well-tolerated. Studies have found that this type of exercise can help the body use insulin more effectively, benefiting blood sugar control.
No serious problems have been reported related to the time of day you exercise. In general, weight training is safe for most people if done correctly. It also offers other health benefits, such as increased strength and improved heart health.
For those considering joining a trial, this information suggests that the exercise routines being tested are likely safe. However, consulting a doctor before starting any new exercise program is always wise.12345Why are researchers excited about this trial?
Researchers are excited about the timing of resistance exercise for insulin sensitivity because it explores how the timing of workouts can impact how the body handles insulin. Unlike standard treatments for improving insulin sensitivity, like medications or diet changes, this approach leverages the body's natural rhythms by conducting resistance exercise sessions in the morning (AM) or evening (PM). This could offer a non-pharmacological method to enhance insulin sensitivity, potentially providing a simple lifestyle modification with significant health benefits. By understanding the optimal timing for exercise, this could lead to more personalized and effective strategies for managing insulin-related conditions.
What evidence suggests that this trial's treatments could be effective for improving insulin sensitivity?
Research shows that strength training can help the body use sugar more effectively by improving its response to insulin. This trial will compare the effects of resistance exercise performed in the morning versus the evening. Some studies suggest that working out in the afternoon or evening might reduce insulin resistance (when the body doesn't respond well to insulin) more effectively than morning exercise. Specifically, one study found that moderate exercise later in the day improved how well adults' bodies used insulin. While strength training is generally beneficial, the time of day might enhance these benefits. Both morning and evening workouts can be helpful, but exercising in the evening might offer extra advantages for managing blood sugar.23456
Are You a Good Fit for This Trial?
This trial is for men and women aged 50-74 with a BMI of at least 25 but less than 45, who are generally healthy but not very active. They shouldn't have major health issues like uncontrolled heart or lung diseases, recent cancer treatment, untreated thyroid problems, or a history of eating disorders or weight loss surgery.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
AM Resistance Exercise
Participants perform resistance exercise in the morning, approximately 1.5 hours after habitual wake time, followed by overnight sleep and oral glucose tolerance tests the next day
Washout
A washout period between the AM and PM exercise conditions
PM Resistance Exercise
Participants perform resistance exercise in the evening, approximately 11 hours after habitual wake time, followed by overnight sleep and oral glucose tolerance tests the next day
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Resistance Exercise Timing
Trial Overview
The study is testing if doing resistance exercises in the morning (AM) versus evening (PM) affects insulin sensitivity and sleep differently. Participants will do workouts once in the AM and once in the PM on separate days with weeks apart to see which timing might help reduce Type 2 Diabetes risk more effectively.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Resistance Exercise intervention taking place in the PM
Resistance Exercise intervention taking place in the AM
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Utah
Lead Sponsor
Published Research Related to This Trial
Citations
Update on the effects of physical activity on insulin sensitivity ...
Recent studies provide further evidence to support the notion that regular PA reduces the risk of insulin resistance, metabolic syndrome and type 2 diabetes.
Exercise Training and Insulin Resistance: A Current Review
... resistance, studies have demonstrated that the impact of vigorous intensity exercise training may be more effective in mitigating insulin resistance. For ...
Timing of resistance exercise and cardiometabolic ...
The objective of this study was to explore whether the time of day (AM vs. PM) resistance exercise is performed influences glucose and insulin concentrations.
Eight weeks of aerobic exercise, but not four, improves ...
The 8-week aerobic exercise regimen demonstrated enhanced insulin sensitivity, upper body strength, and cardiovascular performance in young females
Effects of resistance training on insulin sensitivity in the ...
Conclusion. The findings of this meta-analysis suggest that resistance training is effective for inducing improvement in insulin sensitivity for elderly.
Timing of Resistance Exercise and Cardiometabolic ...
The objective of this study was to explore if the time of day (AM vs PM) resistance exercise is performed influences glucose and insulin concentrations, body ...
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